Control of IGFBP-2 expression by steroids and peptide hormones in vertebrates
IGFBP-2 (1) has been described as a brain tumor oncogene (2) and is widely expressed in cancers from different origins (3-8). IGFBP-2 alone cannot cause malignant transformation, yet progression of brain tumors to higher grade (9) and even has been provided as a protective element in earlier stages...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-04-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00043/full |
| _version_ | 1818555849090531328 |
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| author | Andreas eHoeflich Elisa eWirthgen David eRobert Carl Friedrich eClassen Marion eSpitschak Julia eBrenmoehl |
| author_facet | Andreas eHoeflich Elisa eWirthgen David eRobert Carl Friedrich eClassen Marion eSpitschak Julia eBrenmoehl |
| author_sort | Andreas eHoeflich |
| collection | DOAJ |
| description | IGFBP-2 (1) has been described as a brain tumor oncogene (2) and is widely expressed in cancers from different origins (3-8). IGFBP-2 alone cannot cause malignant transformation, yet progression of brain tumors to higher grade (9) and even has been provided as a protective element in earlier stages of multistage colon carcinogenesis (10). Therefore, it is crucial to understand the factors that determine expression patterns of IGFBP-2 under normal and malignant conditions. The present review provides a comprehensive update of known factors that have an impact on expression of IGFBP-2. |
| first_indexed | 2024-12-12T09:59:00Z |
| format | Article |
| id | doaj.art-708f29f8dc37475b88fcbf6d0b3602b7 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-12T09:59:00Z |
| publishDate | 2014-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-708f29f8dc37475b88fcbf6d0b3602b72022-12-22T00:28:02ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922014-04-01510.3389/fendo.2014.0004383648Control of IGFBP-2 expression by steroids and peptide hormones in vertebratesAndreas eHoeflich0Elisa eWirthgen1David eRobert2Carl Friedrich eClassen3Marion eSpitschak4Julia eBrenmoehl5Leibniz-Institute for Farm Animal BiologyLigandis GbRReference and Translation Center for Cardiac Stem Cell TherapyPediatric Oncology, University Children’s HospitalLeibniz-Institute for Farm Animal BiologyLeibniz-Institute for Farm Animal BiologyIGFBP-2 (1) has been described as a brain tumor oncogene (2) and is widely expressed in cancers from different origins (3-8). IGFBP-2 alone cannot cause malignant transformation, yet progression of brain tumors to higher grade (9) and even has been provided as a protective element in earlier stages of multistage colon carcinogenesis (10). Therefore, it is crucial to understand the factors that determine expression patterns of IGFBP-2 under normal and malignant conditions. The present review provides a comprehensive update of known factors that have an impact on expression of IGFBP-2.http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00043/fullEstradiolPeptide HormonesSteroidsIGFBP-2vetrebrates |
| spellingShingle | Andreas eHoeflich Elisa eWirthgen David eRobert Carl Friedrich eClassen Marion eSpitschak Julia eBrenmoehl Control of IGFBP-2 expression by steroids and peptide hormones in vertebrates Frontiers in Endocrinology Estradiol Peptide Hormones Steroids IGFBP-2 vetrebrates |
| title | Control of IGFBP-2 expression by steroids and peptide hormones in vertebrates |
| title_full | Control of IGFBP-2 expression by steroids and peptide hormones in vertebrates |
| title_fullStr | Control of IGFBP-2 expression by steroids and peptide hormones in vertebrates |
| title_full_unstemmed | Control of IGFBP-2 expression by steroids and peptide hormones in vertebrates |
| title_short | Control of IGFBP-2 expression by steroids and peptide hormones in vertebrates |
| title_sort | control of igfbp 2 expression by steroids and peptide hormones in vertebrates |
| topic | Estradiol Peptide Hormones Steroids IGFBP-2 vetrebrates |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00043/full |
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