Some common candidate genes in arterial hypertension and gallstlone disease pathogenesis
Gallstone disease (GSD) and arterial hypertension (AH) have many common risk factors – age, overweight, dyslipidemia, low physical activity, diabetes mellitus, in addition, the presence of AH is considered by many authors as a risk factor for GSD. Numerous trials are devoted to the study of the cont...
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| Format: | Article |
| Language: | Russian |
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Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics
2014-06-01
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| Series: | Атеросклероз |
| Subjects: | |
| Online Access: | https://ateroskleroz.elpub.ru/jour/article/view/707/649 |
| _version_ | 1797963433419735040 |
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| author | M. S. Lebedeva I. N. Grigorieva N. P. Tatarnikova V. N. Maksimov |
| author_facet | M. S. Lebedeva I. N. Grigorieva N. P. Tatarnikova V. N. Maksimov |
| author_sort | M. S. Lebedeva |
| collection | DOAJ |
| description | Gallstone disease (GSD) and arterial hypertension (AH) have many common risk factors – age, overweight, dyslipidemia, low physical activity, diabetes mellitus, in addition, the presence of AH is considered by many authors as a risk factor for GSD. Numerous trials are devoted to the study of the contribution of gene polymorphisms in the development of AH, but researches about common candidate genes for AH and GSD are rare. In several studies, including a meta-analysis, the association of GSD and APOE4 allele genotype is depicted. Our clinical study in women with GSD in combination with AH shows the greatest frequency of allele APOE4 (21.2) compared with women with GSD without AH (8.0) or with women with isolated AH (10.6, p < 0.05). Also in this study, we found no significant differences in the frequency of genotypes A/A, A/G and G/G polymorphism A145G ADRB1 gene in women with AH in combination with GSD and women with isolated AH. Earlier in epidemiological study we did not found any association of GSD with I/D polymorphism of angiotensin converting enzyme gene. Thus, further research is needed to find a common candidate genes involved in the regulation of blood pressure and in the development of GSD in each population that will help identify patients at highest risk of complications of GSD and AH. |
| first_indexed | 2024-04-11T01:29:19Z |
| format | Article |
| id | doaj.art-70906e561c024100ab589a515faa6464 |
| institution | Directory Open Access Journal |
| issn | 2078-256X |
| language | Russian |
| last_indexed | 2024-04-11T01:29:19Z |
| publishDate | 2014-06-01 |
| publisher | Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics |
| record_format | Article |
| series | Атеросклероз |
| spelling | doaj.art-70906e561c024100ab589a515faa64642023-01-03T10:03:29ZrusSiberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and GeneticsАтеросклероз2078-256X2014-06-011024350Some common candidate genes in arterial hypertension and gallstlone disease pathogenesisM. S. Lebedeva0I. N. Grigorieva1N. P. Tatarnikova2V. N. Maksimov3RAMS; «Russian Railways» Open Joint Stock Company Russian Federation SB RAMS Research Institute of Internal and Preventive MedicineRAMS Russian Federation SB RAMS Research Institute of Internal and Preventive MedicineRAMS Russian Federation SB RAMS Research Institute of Internal and Preventive MedicineRAMS Russian Federation SB RAMS Research Institute of Internal and Preventive MedicineGallstone disease (GSD) and arterial hypertension (AH) have many common risk factors – age, overweight, dyslipidemia, low physical activity, diabetes mellitus, in addition, the presence of AH is considered by many authors as a risk factor for GSD. Numerous trials are devoted to the study of the contribution of gene polymorphisms in the development of AH, but researches about common candidate genes for AH and GSD are rare. In several studies, including a meta-analysis, the association of GSD and APOE4 allele genotype is depicted. Our clinical study in women with GSD in combination with AH shows the greatest frequency of allele APOE4 (21.2) compared with women with GSD without AH (8.0) or with women with isolated AH (10.6, p < 0.05). Also in this study, we found no significant differences in the frequency of genotypes A/A, A/G and G/G polymorphism A145G ADRB1 gene in women with AH in combination with GSD and women with isolated AH. Earlier in epidemiological study we did not found any association of GSD with I/D polymorphism of angiotensin converting enzyme gene. Thus, further research is needed to find a common candidate genes involved in the regulation of blood pressure and in the development of GSD in each population that will help identify patients at highest risk of complications of GSD and AH.https://ateroskleroz.elpub.ru/jour/article/view/707/649gene polymorphismapoeadrb1acegallstone diseasearterial hypertension |
| spellingShingle | M. S. Lebedeva I. N. Grigorieva N. P. Tatarnikova V. N. Maksimov Some common candidate genes in arterial hypertension and gallstlone disease pathogenesis Атеросклероз gene polymorphism apoe adrb1 ace gallstone disease arterial hypertension |
| title | Some common candidate genes in arterial hypertension and gallstlone disease pathogenesis |
| title_full | Some common candidate genes in arterial hypertension and gallstlone disease pathogenesis |
| title_fullStr | Some common candidate genes in arterial hypertension and gallstlone disease pathogenesis |
| title_full_unstemmed | Some common candidate genes in arterial hypertension and gallstlone disease pathogenesis |
| title_short | Some common candidate genes in arterial hypertension and gallstlone disease pathogenesis |
| title_sort | some common candidate genes in arterial hypertension and gallstlone disease pathogenesis |
| topic | gene polymorphism apoe adrb1 ace gallstone disease arterial hypertension |
| url | https://ateroskleroz.elpub.ru/jour/article/view/707/649 |
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