Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression
Introduction: Although various therapies have been adopted to treat cancer, metastasis of tumor cells still is a big challenge that compromises therapeutic benefits.Methods: We herein report an injectable drug-loaded hybrid hydrogel that can achieve sonodynamic therapy (SDT) and chemodyanmic therapy...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1281157/full |
| _version_ | 1797681797867241472 |
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| author | Xiaoying Wang Liyun Zhu Jianhui Zhou Lingzhou Zhao Jingchao Li Changcun Liu |
| author_facet | Xiaoying Wang Liyun Zhu Jianhui Zhou Lingzhou Zhao Jingchao Li Changcun Liu |
| author_sort | Xiaoying Wang |
| collection | DOAJ |
| description | Introduction: Although various therapies have been adopted to treat cancer, metastasis of tumor cells still is a big challenge that compromises therapeutic benefits.Methods: We herein report an injectable drug-loaded hybrid hydrogel that can achieve sonodynamic therapy (SDT) and chemodyanmic therapy (CDT) combined action and suppression of tumor metastasis. This alginate (ALG)-based hydrogel (termed as AMPS) contains manganese dioxide (MnO2) nanoparticles as the CDT agents, an organic polymer as the sonosensitizer, and a SIS3 drug as metastasis inhibitor.Results: AMPS is formed via the chelation of ALG by Ca2+ in tumor microenvironment, in which MnO2 nanoparticles mediate CDT via Fenton-like reaction and the organic polymers enable SDT under ultrasound (US) irradiation by generating singlet oxygen (1O2), allowing for combinational action of CDT and SDT. In addition, SIS3 is released from AMPS hydrogels to inhibit the metastasis of tumor cells. As such, the AMPS enables a combinational action of SDT and CDT to greatly inhibit the growths of subcutaneous tumors in living mice and also completely suppress the tumor metastasis in lungs and livers.Conclusion: This study thus offers a hybrid hydrogel platform for combinational therapy and metastasis suppression simultaneously. |
| first_indexed | 2024-03-11T23:50:14Z |
| format | Article |
| id | doaj.art-7090ccaaed444158aa27a533f3815c30 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-11T23:50:14Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-7090ccaaed444158aa27a533f3815c302023-09-19T07:35:48ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-09-011110.3389/fbioe.2023.12811571281157Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppressionXiaoying Wang0Liyun Zhu1Jianhui Zhou2Lingzhou Zhao3Jingchao Li4Changcun Liu5Office of Hospital Infection and Disease Control and Prevention, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Biological Science and Medical Engineering, Donghua University, Shanghai, ChinaCollege of Biological Science and Medical Engineering, Donghua University, Shanghai, ChinaDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Biological Science and Medical Engineering, Donghua University, Shanghai, ChinaDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaIntroduction: Although various therapies have been adopted to treat cancer, metastasis of tumor cells still is a big challenge that compromises therapeutic benefits.Methods: We herein report an injectable drug-loaded hybrid hydrogel that can achieve sonodynamic therapy (SDT) and chemodyanmic therapy (CDT) combined action and suppression of tumor metastasis. This alginate (ALG)-based hydrogel (termed as AMPS) contains manganese dioxide (MnO2) nanoparticles as the CDT agents, an organic polymer as the sonosensitizer, and a SIS3 drug as metastasis inhibitor.Results: AMPS is formed via the chelation of ALG by Ca2+ in tumor microenvironment, in which MnO2 nanoparticles mediate CDT via Fenton-like reaction and the organic polymers enable SDT under ultrasound (US) irradiation by generating singlet oxygen (1O2), allowing for combinational action of CDT and SDT. In addition, SIS3 is released from AMPS hydrogels to inhibit the metastasis of tumor cells. As such, the AMPS enables a combinational action of SDT and CDT to greatly inhibit the growths of subcutaneous tumors in living mice and also completely suppress the tumor metastasis in lungs and livers.Conclusion: This study thus offers a hybrid hydrogel platform for combinational therapy and metastasis suppression simultaneously.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1281157/fullalginate hydrogelsdrug deliverytumor metastasissonodynamic therapychemodyanmic therapy |
| spellingShingle | Xiaoying Wang Liyun Zhu Jianhui Zhou Lingzhou Zhao Jingchao Li Changcun Liu Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression Frontiers in Bioengineering and Biotechnology alginate hydrogels drug delivery tumor metastasis sonodynamic therapy chemodyanmic therapy |
| title | Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression |
| title_full | Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression |
| title_fullStr | Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression |
| title_full_unstemmed | Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression |
| title_short | Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression |
| title_sort | drug loaded hybrid hydrogels for sonodynamic chemodyanmic therapy and tumor metastasis suppression |
| topic | alginate hydrogels drug delivery tumor metastasis sonodynamic therapy chemodyanmic therapy |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1281157/full |
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