Efficacy and brain mechanism of transcutaneous auricular vagus nerve stimulation for adolescents with mild to moderate depression: Study protocol for a randomized controlled trial
ABSTRACT Background Depression is a common mental illness in childhood and adolescence, with an incidence of 4%–5%; it can lead to impairments in learning and social functioning. Transcutaneous auricular vagus nerve stimulation (taVNS) is a commonly used method of auricular acupuncture point stimula...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-06-01
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| Series: | Pediatric Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ped4.12198 |
| _version_ | 1829491067110555648 |
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| author | Xue Xiao Xiaobing Hou Zhangjing Zhang Ying Li Xue Yu Yanhui Wang Jing Tian Ke Xu |
| author_facet | Xue Xiao Xiaobing Hou Zhangjing Zhang Ying Li Xue Yu Yanhui Wang Jing Tian Ke Xu |
| author_sort | Xue Xiao |
| collection | DOAJ |
| description | ABSTRACT Background Depression is a common mental illness in childhood and adolescence, with an incidence of 4%–5%; it can lead to impairments in learning and social functioning. Transcutaneous auricular vagus nerve stimulation (taVNS) is a commonly used method of auricular acupuncture point stimulation, which is regarded as an effective treatment for adults with depression. The aim of this study was to investigate the efficacy and mechanism of taVNS for adolescents with mild to moderate depression. Methods This randomized controlled clinical trial will include 120 patients aged 12–16 years, all of whom are diagnosed with mild to moderate depression. Patients will be randomly assigned to a taVNS group and a drug control group (sertraline hydrochloride) at a ratio of 1:1. Patients will be evaluated using the 17‐item Hamilton Depression Scale, Hamilton Anxiety Rating Scale, Self‐Rating Depression Scale, Self‐Rating Anxiety Scale, and Pittsburgh Sleep Quality Index scores at baseline, as well as at the 2nd, 4th, 6th, 8th, and 12th weeks. To investigate the underlying neural mechanisms of taVNS treatment from the perspective of the default mode network, multimodal magnetic resonance imaging (MRI; i.e., structural MRI [sMRI], resting state MRI [rsMRI], and pseudocontinuous arterial spin‐labeled [pcASL] MRI) will be used to compare cerebral images among groups. MRI data will also be collected from 40 healthy volunteers to assess whether the participants exhibit normal development of structural and functional components. Discussion Depression is the most common mental disorder in adolescence. Drug treatment can improve depression symptoms; however, the side effects of drug treatments are often severe. This study proposes a simple physiotherapy that aims to treat adolescents with mild to moderate depression. The mechanism of taVNS in the treatment of depression will also be investigated. The results of this study will provide evidence to guide the application of taVNS in adolescents with depression. |
| first_indexed | 2024-12-15T00:31:23Z |
| format | Article |
| id | doaj.art-7091c910ee1e4c7e9468b0e26fc79829 |
| institution | Directory Open Access Journal |
| issn | 2574-2272 |
| language | English |
| last_indexed | 2024-12-15T00:31:23Z |
| publishDate | 2020-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pediatric Investigation |
| spelling | doaj.art-7091c910ee1e4c7e9468b0e26fc798292022-12-21T22:41:59ZengWileyPediatric Investigation2574-22722020-06-014210911710.1002/ped4.12198Efficacy and brain mechanism of transcutaneous auricular vagus nerve stimulation for adolescents with mild to moderate depression: Study protocol for a randomized controlled trialXue Xiao0Xiaobing Hou1Zhangjing Zhang2Ying Li3Xue Yu4Yanhui Wang5Jing Tian6Ke Xu7Department of Psychiatry Beijing First Hospital of Integrated Chinese and Western Medicine Beijing ChinaDepartment of Acupuncture and Moxibustion Beijing First Hospital of Integrated Chinese and Western Medicine Beijing ChinaDepartment of Chinese Medicine University of Hong Kong Shenzhen Hospital (HKU‐SZH) Shenzhen Guangdong ChinaDepartment of Psychiatry Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Psychiatry Beijing First Hospital of Integrated Chinese and Western Medicine Beijing ChinaDepartment of Cardiology Beijing First Hospital of Integrated Chinese and Western Medicine Beijing ChinaDepartment of Psychiatry Beijing First Hospital of Integrated Chinese and Western Medicine Beijing ChinaDepartment of Medical imaging Guang’anmen Hospital China Academy of Chinese Medical Sciences Beijing ChinaABSTRACT Background Depression is a common mental illness in childhood and adolescence, with an incidence of 4%–5%; it can lead to impairments in learning and social functioning. Transcutaneous auricular vagus nerve stimulation (taVNS) is a commonly used method of auricular acupuncture point stimulation, which is regarded as an effective treatment for adults with depression. The aim of this study was to investigate the efficacy and mechanism of taVNS for adolescents with mild to moderate depression. Methods This randomized controlled clinical trial will include 120 patients aged 12–16 years, all of whom are diagnosed with mild to moderate depression. Patients will be randomly assigned to a taVNS group and a drug control group (sertraline hydrochloride) at a ratio of 1:1. Patients will be evaluated using the 17‐item Hamilton Depression Scale, Hamilton Anxiety Rating Scale, Self‐Rating Depression Scale, Self‐Rating Anxiety Scale, and Pittsburgh Sleep Quality Index scores at baseline, as well as at the 2nd, 4th, 6th, 8th, and 12th weeks. To investigate the underlying neural mechanisms of taVNS treatment from the perspective of the default mode network, multimodal magnetic resonance imaging (MRI; i.e., structural MRI [sMRI], resting state MRI [rsMRI], and pseudocontinuous arterial spin‐labeled [pcASL] MRI) will be used to compare cerebral images among groups. MRI data will also be collected from 40 healthy volunteers to assess whether the participants exhibit normal development of structural and functional components. Discussion Depression is the most common mental disorder in adolescence. Drug treatment can improve depression symptoms; however, the side effects of drug treatments are often severe. This study proposes a simple physiotherapy that aims to treat adolescents with mild to moderate depression. The mechanism of taVNS in the treatment of depression will also be investigated. The results of this study will provide evidence to guide the application of taVNS in adolescents with depression.https://doi.org/10.1002/ped4.12198DepressionAdolescentTranscutaneous auricular vagus nerve stimulation (taVNS) |
| spellingShingle | Xue Xiao Xiaobing Hou Zhangjing Zhang Ying Li Xue Yu Yanhui Wang Jing Tian Ke Xu Efficacy and brain mechanism of transcutaneous auricular vagus nerve stimulation for adolescents with mild to moderate depression: Study protocol for a randomized controlled trial Pediatric Investigation Depression Adolescent Transcutaneous auricular vagus nerve stimulation (taVNS) |
| title | Efficacy and brain mechanism of transcutaneous auricular vagus nerve stimulation for adolescents with mild to moderate depression: Study protocol for a randomized controlled trial |
| title_full | Efficacy and brain mechanism of transcutaneous auricular vagus nerve stimulation for adolescents with mild to moderate depression: Study protocol for a randomized controlled trial |
| title_fullStr | Efficacy and brain mechanism of transcutaneous auricular vagus nerve stimulation for adolescents with mild to moderate depression: Study protocol for a randomized controlled trial |
| title_full_unstemmed | Efficacy and brain mechanism of transcutaneous auricular vagus nerve stimulation for adolescents with mild to moderate depression: Study protocol for a randomized controlled trial |
| title_short | Efficacy and brain mechanism of transcutaneous auricular vagus nerve stimulation for adolescents with mild to moderate depression: Study protocol for a randomized controlled trial |
| title_sort | efficacy and brain mechanism of transcutaneous auricular vagus nerve stimulation for adolescents with mild to moderate depression study protocol for a randomized controlled trial |
| topic | Depression Adolescent Transcutaneous auricular vagus nerve stimulation (taVNS) |
| url | https://doi.org/10.1002/ped4.12198 |
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