Storage-induced changes in erythrocyte membrane proteins promote recognition by autoantibodies.

Physiological erythrocyte removal is associated with a selective increase in expression of neoantigens on erythrocytes and their vesicles, and subsequent autologous antibody binding and phagocytosis. Chronic erythrocyte transfusion often leads to immunization and the formation of alloantibodies and...

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Bibliographic Details
Main Authors: Sip Dinkla, Věra M J Novotný, Irma Joosten, Giel J C G M Bosman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3411782?pdf=render

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