Anti-Aging Effect of Dietary Fiber Compound Mediated by Guangxi Longevity Dietary Pattern on Natural Aging Mice
A series of previous studies by our team has shown that the Guangxi longevity dietary pattern contributes to the improvement of human health, but the role of dietary fiber compounds (DFC) in the anti-aging of this dietary pattern has not been studied in depth. Thus, mice were fed with 5%, 15%, and 3...
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MDPI AG
2022-08-01
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| Series: | Nutrients |
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| author | Xiaohan Yu Xiaolin Liang Kunchen Han Fengcui Shi Ning Meng Quanyang Li |
| author_facet | Xiaohan Yu Xiaolin Liang Kunchen Han Fengcui Shi Ning Meng Quanyang Li |
| author_sort | Xiaohan Yu |
| collection | DOAJ |
| description | A series of previous studies by our team has shown that the Guangxi longevity dietary pattern contributes to the improvement of human health, but the role of dietary fiber compounds (DFC) in the anti-aging of this dietary pattern has not been studied in depth. Thus, mice were fed with 5%, 15%, and 30% of the characteristic dietary fiber compound (CDFC) (compounded according to the longevity dietary pattern) for 8 weeks, and their learning memory capacity, antioxidant capacity, and inflammatory markers, as well as typical microorganisms in the intestinal tract were analyzed to investigate the anti-aging effects of the CDFC under the Guangxi longevity dietary pattern on naturally aging mice. The results showed that CDFC had a bidirectional effect on body weight regulation; increased brain, spleen, and cardiac indices, of which the medium dose was the best. Meanwhile, CDFC also had a maintenance and improvement effect on learning and memory ability in aging mice, as well as improved antioxidant capacity and reduced inflammation level. The neuronal cell necrosis in the hippocampus of mice was effectively alleviated. The expression of <i>Escherichia coli</i> and <i>Bacteroides</i> was significantly reduced, and the expression of <i>Bifidobacterium</i> and <i>Lactobacillus</i> increased. In addition, the optimal amount of CDFC added from the level of experimental animals was in a certain interval above and below 15%. The combined results indicated that CDFC mediated by the Guangxi longevity dietary pattern had significant anti-aging effects, thus theoretically proving that dietary fiber compound contributes to human longevity. |
| first_indexed | 2024-03-09T10:06:34Z |
| format | Article |
| id | doaj.art-70985d0d43ef4462925cf11f2d7d765f |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T10:06:34Z |
| publishDate | 2022-08-01 |
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| series | Nutrients |
| spelling | doaj.art-70985d0d43ef4462925cf11f2d7d765f2023-12-01T23:05:40ZengMDPI AGNutrients2072-66432022-08-011415318110.3390/nu14153181Anti-Aging Effect of Dietary Fiber Compound Mediated by Guangxi Longevity Dietary Pattern on Natural Aging MiceXiaohan Yu0Xiaolin Liang1Kunchen Han2Fengcui Shi3Ning Meng4Quanyang Li5College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, ChinaNational Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, ChinaCollege of Light Industry and Food Engineering, Guangxi University, Nanning 530004, ChinaCollege of Light Industry and Food Engineering, Guangxi University, Nanning 530004, ChinaCollege of Light Industry and Food Engineering, Guangxi University, Nanning 530004, ChinaCollege of Light Industry and Food Engineering, Guangxi University, Nanning 530004, ChinaA series of previous studies by our team has shown that the Guangxi longevity dietary pattern contributes to the improvement of human health, but the role of dietary fiber compounds (DFC) in the anti-aging of this dietary pattern has not been studied in depth. Thus, mice were fed with 5%, 15%, and 30% of the characteristic dietary fiber compound (CDFC) (compounded according to the longevity dietary pattern) for 8 weeks, and their learning memory capacity, antioxidant capacity, and inflammatory markers, as well as typical microorganisms in the intestinal tract were analyzed to investigate the anti-aging effects of the CDFC under the Guangxi longevity dietary pattern on naturally aging mice. The results showed that CDFC had a bidirectional effect on body weight regulation; increased brain, spleen, and cardiac indices, of which the medium dose was the best. Meanwhile, CDFC also had a maintenance and improvement effect on learning and memory ability in aging mice, as well as improved antioxidant capacity and reduced inflammation level. The neuronal cell necrosis in the hippocampus of mice was effectively alleviated. The expression of <i>Escherichia coli</i> and <i>Bacteroides</i> was significantly reduced, and the expression of <i>Bifidobacterium</i> and <i>Lactobacillus</i> increased. In addition, the optimal amount of CDFC added from the level of experimental animals was in a certain interval above and below 15%. The combined results indicated that CDFC mediated by the Guangxi longevity dietary pattern had significant anti-aging effects, thus theoretically proving that dietary fiber compound contributes to human longevity.https://www.mdpi.com/2072-6643/14/15/3181characteristic dietary fiber compoundnatural aging micebidirectional adjustmentantioxidantgut microbesoptimal intake parameters |
| spellingShingle | Xiaohan Yu Xiaolin Liang Kunchen Han Fengcui Shi Ning Meng Quanyang Li Anti-Aging Effect of Dietary Fiber Compound Mediated by Guangxi Longevity Dietary Pattern on Natural Aging Mice Nutrients characteristic dietary fiber compound natural aging mice bidirectional adjustment antioxidant gut microbes optimal intake parameters |
| title | Anti-Aging Effect of Dietary Fiber Compound Mediated by Guangxi Longevity Dietary Pattern on Natural Aging Mice |
| title_full | Anti-Aging Effect of Dietary Fiber Compound Mediated by Guangxi Longevity Dietary Pattern on Natural Aging Mice |
| title_fullStr | Anti-Aging Effect of Dietary Fiber Compound Mediated by Guangxi Longevity Dietary Pattern on Natural Aging Mice |
| title_full_unstemmed | Anti-Aging Effect of Dietary Fiber Compound Mediated by Guangxi Longevity Dietary Pattern on Natural Aging Mice |
| title_short | Anti-Aging Effect of Dietary Fiber Compound Mediated by Guangxi Longevity Dietary Pattern on Natural Aging Mice |
| title_sort | anti aging effect of dietary fiber compound mediated by guangxi longevity dietary pattern on natural aging mice |
| topic | characteristic dietary fiber compound natural aging mice bidirectional adjustment antioxidant gut microbes optimal intake parameters |
| url | https://www.mdpi.com/2072-6643/14/15/3181 |
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