The Shear Stress–Regulated Expression of Glypican-4 in Endothelial Dysfunction In Vitro and Its Clinical Significance in Atherosclerosis

The Shear Stress–Regulated Expression of Glypican-4 in Endothelial Dysfunction In Vitro and Its Clinical Significance in Atherosclerosis

Retention of circulating lipoproteins by their interaction with extracellular matrix molecules has been suggested as an underlying mechanism for atherosclerosis. We investigated the role of glypican-4 (GPC4), a heparan sulfate (HS) proteoglycan, in the development of endothelial dysfunction and plaq...

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Bibliographic Details
Main Authors: Katharina Urschel, Karsten P. Hug, Hanxiao Zuo, Michael Büttner, Roman Furtmair, Constanze Kuehn, Florian M. Stumpfe, Balaz Botos, Stephan Achenbach, Yan Yuan, Barbara Dietel, Miyuki Tauchi
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
glypican-4
heparan sulfate
endothelial dysfunction
atherosclerosis
plaque
shear stress
Online Access:https://www.mdpi.com/1422-0067/24/14/11595

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https://www.mdpi.com/1422-0067/24/14/11595

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