Clinical characteristics, radiologic features, and histopathology of biopsied lacrimal gland tumors
Abstract Herein, we described the clinicopathologic and radiologic features of biopsied lacrimal gland tumors. A retrospective case series of 79 patients treated between 2004 and 2021 was reviewed. The median age was 48.9 years (range 18.3–88.3 years), with 51.9% females. The histopathologic diagnos...
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| Format: | Article |
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Nature Portfolio
2023-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-43817-0 |
| _version_ | 1797559547454291968 |
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| author | Orapan Aryasit Pawarin Amornthatree Wantanee Dangboon Tsutsumi Wantanee Sittivarakul Alan Frederick Geater Supaporn Tengtrisorn Virintorn Prapakornkovit |
| author_facet | Orapan Aryasit Pawarin Amornthatree Wantanee Dangboon Tsutsumi Wantanee Sittivarakul Alan Frederick Geater Supaporn Tengtrisorn Virintorn Prapakornkovit |
| author_sort | Orapan Aryasit |
| collection | DOAJ |
| description | Abstract Herein, we described the clinicopathologic and radiologic features of biopsied lacrimal gland tumors. A retrospective case series of 79 patients treated between 2004 and 2021 was reviewed. The median age was 48.9 years (range 18.3–88.3 years), with 51.9% females. The histopathologic diagnoses were as follows: immunoglobulin G4-related disease (IgG4-RD) = 23, reactive lymphoid hyperplasia = 14, lymphoma = 14, nonspecific inflammation = 10, adenoid cystic carcinoma (ACC) = 9, and pleomorphic adenoma = 9. The proportion of histopathologic diagnoses did not differ significantly over the range of symptom durations (≤ 1 month, > 1–3 months, > 3 months). Patients with ACC had significantly shorter symptom duration and more frequent proptosis than those with pleomorphic adenoma (p = 0.040 and p = 0.009, respectively). Patients with IgG4-RD were older (median 54.3 years) than those with nonspecific inflammation (36.2 years; p = 0.046). Patients with ACC were more likely to present with diplopia than those with lymphoma (p < 0.001). The superior wedge sign increased the likelihood of ACC compared with that of non-epithelial non-malignant lacrimal gland tumors (relative risk ratio = 13.44, p = 0.002). The overall survival of patients with ACC and lymphoma did not differ significantly. Although these patients present with a short symptom duration, urgent orbital imaging, tissue biopsy, and prompt treatment should be performed in patients with lacrimal gland tumors. |
| first_indexed | 2024-03-10T17:46:56Z |
| format | Article |
| id | doaj.art-709b2e352923462f826bb4cd9fe9d8e2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:46:56Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-709b2e352923462f826bb4cd9fe9d8e22023-11-20T09:30:13ZengNature PortfolioScientific Reports2045-23222023-10-011311710.1038/s41598-023-43817-0Clinical characteristics, radiologic features, and histopathology of biopsied lacrimal gland tumorsOrapan Aryasit0Pawarin Amornthatree1Wantanee Dangboon Tsutsumi2Wantanee Sittivarakul3Alan Frederick Geater4Supaporn Tengtrisorn5Virintorn Prapakornkovit6Department of Ophthalmology, Faculty of Medicine, Prince of Songkla UniversityDepartment of Ophthalmology, Faculty of Medicine, Prince of Songkla UniversityDepartment of Ophthalmology, Faculty of Medicine, Prince of Songkla UniversityDepartment of Ophthalmology, Faculty of Medicine, Prince of Songkla UniversityEpidemiology Unit, Faculty of Medicine, Prince of Songkla UniversityDepartment of Ophthalmology, Faculty of Medicine, Prince of Songkla UniversityDepartment of Ophthalmology, Faculty of Medicine, Prince of Songkla UniversityAbstract Herein, we described the clinicopathologic and radiologic features of biopsied lacrimal gland tumors. A retrospective case series of 79 patients treated between 2004 and 2021 was reviewed. The median age was 48.9 years (range 18.3–88.3 years), with 51.9% females. The histopathologic diagnoses were as follows: immunoglobulin G4-related disease (IgG4-RD) = 23, reactive lymphoid hyperplasia = 14, lymphoma = 14, nonspecific inflammation = 10, adenoid cystic carcinoma (ACC) = 9, and pleomorphic adenoma = 9. The proportion of histopathologic diagnoses did not differ significantly over the range of symptom durations (≤ 1 month, > 1–3 months, > 3 months). Patients with ACC had significantly shorter symptom duration and more frequent proptosis than those with pleomorphic adenoma (p = 0.040 and p = 0.009, respectively). Patients with IgG4-RD were older (median 54.3 years) than those with nonspecific inflammation (36.2 years; p = 0.046). Patients with ACC were more likely to present with diplopia than those with lymphoma (p < 0.001). The superior wedge sign increased the likelihood of ACC compared with that of non-epithelial non-malignant lacrimal gland tumors (relative risk ratio = 13.44, p = 0.002). The overall survival of patients with ACC and lymphoma did not differ significantly. Although these patients present with a short symptom duration, urgent orbital imaging, tissue biopsy, and prompt treatment should be performed in patients with lacrimal gland tumors.https://doi.org/10.1038/s41598-023-43817-0 |
| spellingShingle | Orapan Aryasit Pawarin Amornthatree Wantanee Dangboon Tsutsumi Wantanee Sittivarakul Alan Frederick Geater Supaporn Tengtrisorn Virintorn Prapakornkovit Clinical characteristics, radiologic features, and histopathology of biopsied lacrimal gland tumors Scientific Reports |
| title | Clinical characteristics, radiologic features, and histopathology of biopsied lacrimal gland tumors |
| title_full | Clinical characteristics, radiologic features, and histopathology of biopsied lacrimal gland tumors |
| title_fullStr | Clinical characteristics, radiologic features, and histopathology of biopsied lacrimal gland tumors |
| title_full_unstemmed | Clinical characteristics, radiologic features, and histopathology of biopsied lacrimal gland tumors |
| title_short | Clinical characteristics, radiologic features, and histopathology of biopsied lacrimal gland tumors |
| title_sort | clinical characteristics radiologic features and histopathology of biopsied lacrimal gland tumors |
| url | https://doi.org/10.1038/s41598-023-43817-0 |
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