Expression of LncRNA AK09398 and Relationship with Prognosis in Patients with Small Cell Lung Cancer
Background and objective Small cell lung cancer (SCLC) accounts for approximately 15% of lung cancer. The poor prognosis of SCLC patients is attributed to the early blood and lymph node metastasis. However, the mechanism of SCLC is still unclear. Recent studies show that LncRNA plays an important ro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2016-11-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2016.11.06 |
| _version_ | 1818344378255540224 |
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| author | Bin LIU Xiaoqin LIU Ye YANG Jun GE Jing LI |
| author_facet | Bin LIU Xiaoqin LIU Ye YANG Jun GE Jing LI |
| author_sort | Bin LIU |
| collection | DOAJ |
| description | Background and objective Small cell lung cancer (SCLC) accounts for approximately 15% of lung cancer. The poor prognosis of SCLC patients is attributed to the early blood and lymph node metastasis. However, the mechanism of SCLC is still unclear. Recent studies show that LncRNA plays an important role in the development, metastasis, and apoptosis of tumor. Thus, the present study aimed to investigate the expression and clinical significance of LncRNA AK09398 in SCLC. Methods Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to detect the expression of LncRNA AK09398 in 118 cases of SCLC and non-cancerous tissues. qRT-PCR was also utilized to analyze the relationship between the expression and clinical pathological characteristics and prognosis of SCLC. Results The expression of LncRNA AK09398 in lung cancer tissues was (7.813±0.373). This value was significantly increased in paracarcinoma tissues (1.782±0.116) and normal lung tissues (1.209±0.200). The difference was statistically significant (F=58.41, P<0.001). AK09398 expression was positively correlated with disease stage, lymph node and distant metastasis, chemosensitivity, and survival status (P<0.05). However, AK09398 expression was not associated with gender and age (P>0.05). Kaplan-Meier analysis demonstrated that high expression level of AK09398 contributed to poor overall survival (P<0.001) and progression-free survival (P<0.001). The multivariate survival analysis also indicated that AK09398 expression, disease stage, and distant metastasis could be independent prognostic markers. Conclusion LncRNA AK09398 is involved in the development of SCLC and can be used as a molecular marker to evaluate the prognosis of SCLC. |
| first_indexed | 2024-12-13T16:45:31Z |
| format | Article |
| id | doaj.art-709c7b75d72547eeab11bc19a977ac61 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-13T16:45:31Z |
| publishDate | 2016-11-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-709c7b75d72547eeab11bc19a977ac612022-12-21T23:38:11ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872016-11-01191175475910.3779/j.issn.1009-3419.2016.11.06Expression of LncRNA AK09398 and Relationship with Prognosis in Patients with Small Cell Lung CancerBin LIU0Xiaoqin LIU1Ye YANG2Jun GE3Jing LI4Department of Pulmonary Tumor Ward, Sichuan Cancer Hospital, Chengdu 610041, ChinaDepartment of Pulmonary Tumor Ward, Sichuan Cancer Hospital, Chengdu 610041, ChinaDepartment of Pulmonary Tumor Ward, Sichuan Cancer Hospital, Chengdu 610041, ChinaDepartment of Pulmonary Tumor Ward, Sichuan Cancer Hospital, Chengdu 610041, Chinathe Second Outpatient Department, Sichuan Cancer Hospital, Chengdu 610041, ChinaBackground and objective Small cell lung cancer (SCLC) accounts for approximately 15% of lung cancer. The poor prognosis of SCLC patients is attributed to the early blood and lymph node metastasis. However, the mechanism of SCLC is still unclear. Recent studies show that LncRNA plays an important role in the development, metastasis, and apoptosis of tumor. Thus, the present study aimed to investigate the expression and clinical significance of LncRNA AK09398 in SCLC. Methods Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to detect the expression of LncRNA AK09398 in 118 cases of SCLC and non-cancerous tissues. qRT-PCR was also utilized to analyze the relationship between the expression and clinical pathological characteristics and prognosis of SCLC. Results The expression of LncRNA AK09398 in lung cancer tissues was (7.813±0.373). This value was significantly increased in paracarcinoma tissues (1.782±0.116) and normal lung tissues (1.209±0.200). The difference was statistically significant (F=58.41, P<0.001). AK09398 expression was positively correlated with disease stage, lymph node and distant metastasis, chemosensitivity, and survival status (P<0.05). However, AK09398 expression was not associated with gender and age (P>0.05). Kaplan-Meier analysis demonstrated that high expression level of AK09398 contributed to poor overall survival (P<0.001) and progression-free survival (P<0.001). The multivariate survival analysis also indicated that AK09398 expression, disease stage, and distant metastasis could be independent prognostic markers. Conclusion LncRNA AK09398 is involved in the development of SCLC and can be used as a molecular marker to evaluate the prognosis of SCLC.http://dx.doi.org/10.3779/j.issn.1009-3419.2016.11.06Lung neoplasmsLncRNA AK09398Prognosis |
| spellingShingle | Bin LIU Xiaoqin LIU Ye YANG Jun GE Jing LI Expression of LncRNA AK09398 and Relationship with Prognosis in Patients with Small Cell Lung Cancer Chinese Journal of Lung Cancer Lung neoplasms LncRNA AK09398 Prognosis |
| title | Expression of LncRNA AK09398 and Relationship with Prognosis in Patients with Small Cell Lung Cancer |
| title_full | Expression of LncRNA AK09398 and Relationship with Prognosis in Patients with Small Cell Lung Cancer |
| title_fullStr | Expression of LncRNA AK09398 and Relationship with Prognosis in Patients with Small Cell Lung Cancer |
| title_full_unstemmed | Expression of LncRNA AK09398 and Relationship with Prognosis in Patients with Small Cell Lung Cancer |
| title_short | Expression of LncRNA AK09398 and Relationship with Prognosis in Patients with Small Cell Lung Cancer |
| title_sort | expression of lncrna ak09398 and relationship with prognosis in patients with small cell lung cancer |
| topic | Lung neoplasms LncRNA AK09398 Prognosis |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2016.11.06 |
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