Cost-effectiveness of alternative minimum recall intervals between whole blood donations.
<h4>Background</h4>The INTERVAL trial showed shorter inter-donation intervals could safely increase the frequency of whole-blood donation. We extended the INTERVAL trial to consider the relative cost-effectiveness of reduced inter-donation intervals.<h4>Methods</h4>Our within...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0272854 |
| _version_ | 1827980623911845888 |
|---|---|
| author | Zia Sadique Sarah Willis Kaat De Corte Mark Pennington Carmel Moore Stephen Kaptoge Emanuele Di Angelantonio Gail Miflin David J Roberts Richard Grieve |
| author_facet | Zia Sadique Sarah Willis Kaat De Corte Mark Pennington Carmel Moore Stephen Kaptoge Emanuele Di Angelantonio Gail Miflin David J Roberts Richard Grieve |
| author_sort | Zia Sadique |
| collection | DOAJ |
| description | <h4>Background</h4>The INTERVAL trial showed shorter inter-donation intervals could safely increase the frequency of whole-blood donation. We extended the INTERVAL trial to consider the relative cost-effectiveness of reduced inter-donation intervals.<h4>Methods</h4>Our within-trial cost-effectiveness analysis (CEA) used data from 44,863 whole-blood donors randomly assigned to 12, 10 or 8 week (males), and 16, 14 or 12 week inter-donation intervals (females). The CEA analysed the number of whole-blood donations, deferrals including low- haemoglobin deferrals, and donors' health-related quality of life (QoL) to report costs and cost-effectiveness over two years.<h4>Findings</h4>The mean number of blood donation visits over two years was higher for the reduced interval strategies, for males (7.76, 6.60 and 5.68 average donations in the 8-, 10- and 12- week arms) and for females (5.10, 4.60 and 4.01 donations in the 12-, 14- and 16- week arms). For males, the average rate of deferral for low haemoglobin per session attended, was 5.71% (8- week arm), 3.73% (10- week), and 2.55% (12- week), and for females the rates were: 7.92% (12-week), 6.63% (14- week), and 5.05% (16- week). Donors' QoL was similar across strategies, although self-reported symptoms were increased with shorter donation intervals. The shorter interval strategies increased average cost, with incremental cost-effectiveness ratios of £9.51 (95% CI 9.33 to 9.69) per additional whole-blood donation for the 8- versus 12- week interval for males, and £10.17 (95% CI 9.80 to 10.54) for the 12- versus 16- week interval arm for females.<h4>Conclusions</h4>Over two years, reducing the minimum donation interval could provide additional units of whole-blood at a small additional cost, including for those donor subgroups whose blood type is in relatively high demand. However, the significance of self-reported symptoms needs to be investigated further before these policies are expanded. |
| first_indexed | 2024-04-09T21:55:17Z |
| format | Article |
| id | doaj.art-709d477a9bdd4ba78ed1d12b4b260966 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T21:55:17Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-709d477a9bdd4ba78ed1d12b4b2609662023-03-24T05:32:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01178e027285410.1371/journal.pone.0272854Cost-effectiveness of alternative minimum recall intervals between whole blood donations.Zia SadiqueSarah WillisKaat De CorteMark PenningtonCarmel MooreStephen KaptogeEmanuele Di AngelantonioGail MiflinDavid J RobertsRichard Grieve<h4>Background</h4>The INTERVAL trial showed shorter inter-donation intervals could safely increase the frequency of whole-blood donation. We extended the INTERVAL trial to consider the relative cost-effectiveness of reduced inter-donation intervals.<h4>Methods</h4>Our within-trial cost-effectiveness analysis (CEA) used data from 44,863 whole-blood donors randomly assigned to 12, 10 or 8 week (males), and 16, 14 or 12 week inter-donation intervals (females). The CEA analysed the number of whole-blood donations, deferrals including low- haemoglobin deferrals, and donors' health-related quality of life (QoL) to report costs and cost-effectiveness over two years.<h4>Findings</h4>The mean number of blood donation visits over two years was higher for the reduced interval strategies, for males (7.76, 6.60 and 5.68 average donations in the 8-, 10- and 12- week arms) and for females (5.10, 4.60 and 4.01 donations in the 12-, 14- and 16- week arms). For males, the average rate of deferral for low haemoglobin per session attended, was 5.71% (8- week arm), 3.73% (10- week), and 2.55% (12- week), and for females the rates were: 7.92% (12-week), 6.63% (14- week), and 5.05% (16- week). Donors' QoL was similar across strategies, although self-reported symptoms were increased with shorter donation intervals. The shorter interval strategies increased average cost, with incremental cost-effectiveness ratios of £9.51 (95% CI 9.33 to 9.69) per additional whole-blood donation for the 8- versus 12- week interval for males, and £10.17 (95% CI 9.80 to 10.54) for the 12- versus 16- week interval arm for females.<h4>Conclusions</h4>Over two years, reducing the minimum donation interval could provide additional units of whole-blood at a small additional cost, including for those donor subgroups whose blood type is in relatively high demand. However, the significance of self-reported symptoms needs to be investigated further before these policies are expanded.https://doi.org/10.1371/journal.pone.0272854 |
| spellingShingle | Zia Sadique Sarah Willis Kaat De Corte Mark Pennington Carmel Moore Stephen Kaptoge Emanuele Di Angelantonio Gail Miflin David J Roberts Richard Grieve Cost-effectiveness of alternative minimum recall intervals between whole blood donations. PLoS ONE |
| title | Cost-effectiveness of alternative minimum recall intervals between whole blood donations. |
| title_full | Cost-effectiveness of alternative minimum recall intervals between whole blood donations. |
| title_fullStr | Cost-effectiveness of alternative minimum recall intervals between whole blood donations. |
| title_full_unstemmed | Cost-effectiveness of alternative minimum recall intervals between whole blood donations. |
| title_short | Cost-effectiveness of alternative minimum recall intervals between whole blood donations. |
| title_sort | cost effectiveness of alternative minimum recall intervals between whole blood donations |
| url | https://doi.org/10.1371/journal.pone.0272854 |
| work_keys_str_mv | AT ziasadique costeffectivenessofalternativeminimumrecallintervalsbetweenwholeblooddonations AT sarahwillis costeffectivenessofalternativeminimumrecallintervalsbetweenwholeblooddonations AT kaatdecorte costeffectivenessofalternativeminimumrecallintervalsbetweenwholeblooddonations AT markpennington costeffectivenessofalternativeminimumrecallintervalsbetweenwholeblooddonations AT carmelmoore costeffectivenessofalternativeminimumrecallintervalsbetweenwholeblooddonations AT stephenkaptoge costeffectivenessofalternativeminimumrecallintervalsbetweenwholeblooddonations AT emanuelediangelantonio costeffectivenessofalternativeminimumrecallintervalsbetweenwholeblooddonations AT gailmiflin costeffectivenessofalternativeminimumrecallintervalsbetweenwholeblooddonations AT davidjroberts costeffectivenessofalternativeminimumrecallintervalsbetweenwholeblooddonations AT richardgrieve costeffectivenessofalternativeminimumrecallintervalsbetweenwholeblooddonations |