AUTISM SPECTRUM DISORDER AND POSTNATAL FACTORS: A CASE-CONTROL STUDY IN BRAZIL
ABSTRACT Objective: To estimate the magnitude of the association between Autism Spectrum Disorder (ASD) and postnatal factors in a Brazilian population. Methods: A case-control study was performed with 253 individuals diagnosed with ASD and 886 individuals without signs of the disorder. A semi-s...
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| Format: | Article |
| Language: | English |
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Sociedade de Pediatria de São Paulo
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| Series: | Revista Paulista de Pediatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822019005014102&lng=en&tlng=en |
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| author | Fernanda Alves Maia Liliane Marta Mendes Oliveira Maria Tereza Carvalho Almeida Maria Rachel Alves Vanessa Souza de Araújo Saeger Victor Bruno da Silva Victória Spínola Duarte de Oliveira Hercílio Martelli Junior Maria Fernanda Santos Figueiredo Brito Marise Fagundes da Silveira |
| author_facet | Fernanda Alves Maia Liliane Marta Mendes Oliveira Maria Tereza Carvalho Almeida Maria Rachel Alves Vanessa Souza de Araújo Saeger Victor Bruno da Silva Victória Spínola Duarte de Oliveira Hercílio Martelli Junior Maria Fernanda Santos Figueiredo Brito Marise Fagundes da Silveira |
| author_sort | Fernanda Alves Maia |
| collection | DOAJ |
| description | ABSTRACT Objective: To estimate the magnitude of the association between Autism Spectrum Disorder (ASD) and postnatal factors in a Brazilian population. Methods: A case-control study was performed with 253 individuals diagnosed with ASD and 886 individuals without signs of the disorder. A semi-structured questionnaire and the multiple logistic regression model were adopted in the data analysis. To estimate the magnitude of associations, the crude and adjusted Odds Ratio (OR) was used. Results: An association with the following factors was found: having been born with congenital malformation (OR 4.24; confidence interval of 95% - 95%CI 1.92-9.34), neonatal jaundice (OR 1.43; 95%CI 1.01-2.02), absence of crying at birth and seizure episode in childhood (OR 5.75; 95%CI 3.37-9.81). The magnitude of the association was higher in the children/adolescents who had two or more postnatal complications (OR 6.39; 95%CI 4.10-10.00). Conclusions: The findings of the present study suggest that malformation, neonatal jaundice, absence of crying at birth and seizure episodes in childhood are important factors to be considered when studying the etiology of ASD. |
| first_indexed | 2024-04-13T02:35:44Z |
| format | Article |
| id | doaj.art-709eac3a28a0427ab55ff44ec4909924 |
| institution | Directory Open Access Journal |
| issn | 1984-0462 |
| language | English |
| last_indexed | 2024-04-13T02:35:44Z |
| publisher | Sociedade de Pediatria de São Paulo |
| record_format | Article |
| series | Revista Paulista de Pediatria |
| spelling | doaj.art-709eac3a28a0427ab55ff44ec49099242022-12-22T03:06:22ZengSociedade de Pediatria de São PauloRevista Paulista de Pediatria1984-046210.1590/1984-0462/;2019;37;4;00006S0103-05822019005014102AUTISM SPECTRUM DISORDER AND POSTNATAL FACTORS: A CASE-CONTROL STUDY IN BRAZILFernanda Alves MaiaLiliane Marta Mendes OliveiraMaria Tereza Carvalho AlmeidaMaria Rachel AlvesVanessa Souza de Araújo SaegerVictor Bruno da SilvaVictória Spínola Duarte de OliveiraHercílio Martelli JuniorMaria Fernanda Santos Figueiredo BritoMarise Fagundes da SilveiraABSTRACT Objective: To estimate the magnitude of the association between Autism Spectrum Disorder (ASD) and postnatal factors in a Brazilian population. Methods: A case-control study was performed with 253 individuals diagnosed with ASD and 886 individuals without signs of the disorder. A semi-structured questionnaire and the multiple logistic regression model were adopted in the data analysis. To estimate the magnitude of associations, the crude and adjusted Odds Ratio (OR) was used. Results: An association with the following factors was found: having been born with congenital malformation (OR 4.24; confidence interval of 95% - 95%CI 1.92-9.34), neonatal jaundice (OR 1.43; 95%CI 1.01-2.02), absence of crying at birth and seizure episode in childhood (OR 5.75; 95%CI 3.37-9.81). The magnitude of the association was higher in the children/adolescents who had two or more postnatal complications (OR 6.39; 95%CI 4.10-10.00). Conclusions: The findings of the present study suggest that malformation, neonatal jaundice, absence of crying at birth and seizure episodes in childhood are important factors to be considered when studying the etiology of ASD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822019005014102&lng=en&tlng=enAutismoFatores de riscoCriançaRecém-nascido |
| spellingShingle | Fernanda Alves Maia Liliane Marta Mendes Oliveira Maria Tereza Carvalho Almeida Maria Rachel Alves Vanessa Souza de Araújo Saeger Victor Bruno da Silva Victória Spínola Duarte de Oliveira Hercílio Martelli Junior Maria Fernanda Santos Figueiredo Brito Marise Fagundes da Silveira AUTISM SPECTRUM DISORDER AND POSTNATAL FACTORS: A CASE-CONTROL STUDY IN BRAZIL Revista Paulista de Pediatria Autismo Fatores de risco Criança Recém-nascido |
| title | AUTISM SPECTRUM DISORDER AND POSTNATAL FACTORS: A CASE-CONTROL STUDY IN BRAZIL |
| title_full | AUTISM SPECTRUM DISORDER AND POSTNATAL FACTORS: A CASE-CONTROL STUDY IN BRAZIL |
| title_fullStr | AUTISM SPECTRUM DISORDER AND POSTNATAL FACTORS: A CASE-CONTROL STUDY IN BRAZIL |
| title_full_unstemmed | AUTISM SPECTRUM DISORDER AND POSTNATAL FACTORS: A CASE-CONTROL STUDY IN BRAZIL |
| title_short | AUTISM SPECTRUM DISORDER AND POSTNATAL FACTORS: A CASE-CONTROL STUDY IN BRAZIL |
| title_sort | autism spectrum disorder and postnatal factors a case control study in brazil |
| topic | Autismo Fatores de risco Criança Recém-nascido |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822019005014102&lng=en&tlng=en |
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