SOCS3 inhibits the mesenchymal stromal cell secretory factor SDF-1-mediated improvement of islet function in non-obese diabetic mice

SOCS3 inhibits the mesenchymal stromal cell secretory factor SDF-1-mediated improvement of islet function in non-obese diabetic mice

Abstract Background Islet transplantation is used therapeutically in a minority of patients with type 1 diabetes (T1D). However, successful outcomes are hampered by early islet β-cell loss caused by immune rejection and autoimmunity. Recent studies have demonstrated that mesenchymal stromal cells ca...

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Bibliographic Details
Main Authors: Mingxing Sui, Tuo Li, Hanlan Lu, Yanhua Li, Juan Huang, Pei Zhang, Shusen Wang, Li Zeng
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Stem Cell Research & Therapy
Subjects:
CXCR4
Islet transplantation
SDF-1
SOCS3
Type 1 diabetes
Online Access:https://doi.org/10.1186/s13287-023-03347-y

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