Natural history of gastroesophageal reflux in infancy: new data from a prospective cohort
Abstract Background Gastroesophageal reflux (GER) is common in infants. Gastroesophageal reflux disease (GERD) is defined as GER leading to troublesome symptoms that affect daily functioning and/or complications. This study is aimed at determining the prevalence and progression of GER and GERD in a...
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| Format: | Article |
| Language: | English |
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BMC
2020-04-01
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| Series: | BMC Pediatrics |
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| Online Access: | http://link.springer.com/article/10.1186/s12887-020-02047-3 |
| _version_ | 1818256829928439808 |
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| author | Marlène Curien-Chotard Prévost Jantchou |
| author_facet | Marlène Curien-Chotard Prévost Jantchou |
| author_sort | Marlène Curien-Chotard |
| collection | DOAJ |
| description | Abstract Background Gastroesophageal reflux (GER) is common in infants. Gastroesophageal reflux disease (GERD) is defined as GER leading to troublesome symptoms that affect daily functioning and/or complications. This study is aimed at determining the prevalence and progression of GER and GERD in a cohort of healthy term infants from birth to 12 months old. Methods We conducted a prospective cohort study including all full-term living neonates born at Besançon Teaching Hospital, France. Parents completed a clinical report form and the Infant Gastroesophageal Reflux Questionnaire-Revised (I-GERQ-R) at 1, 3, 6, 10, and 12 months of age. GER was defined as score ≥ 1 to the first question with I-GERQ-R score < 16, and GERD as score ≥ 1 to the first question with I-GERQ-R score ≥ 16. Regurgitation was based on the answer to the first question of the I-GERQ-R as anything coming out of the mouth daily. Results 157/347 births were included (83 boys). The prevalence of regurgitation at least once a day was 45.7% overall. In total: 72, 69, 56, 18, and 13% of infants regurgitated at least once a day at 1, 3, 6, 10, and 12 months of age, respectively. Physiological GER affected 53, 59, 51, 16, and 12% of infants; GERD, 19, 9, 5, 2, and 2%, respectively. Two risk factors were identified: family history of GER and exposure to passive smoking. Treatment included dietary modification (14%) and pharmacotherapy (5%). Conclusion Physiological GER peaked at 3 months, GERD at 1 month. Most cases resolved on their own. GER and GERD are very common in the infant’s population and parents should be reassured/educated regarding symptoms, warning signs, and generally favorable prognosis. I-GERQ-R is useful to the clinical screening and follow up for GER and GERD. |
| first_indexed | 2024-12-12T17:33:59Z |
| format | Article |
| id | doaj.art-709f9b73a1e54c3da64e32fd6b842318 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-12T17:33:59Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-709f9b73a1e54c3da64e32fd6b8423182022-12-22T00:17:16ZengBMCBMC Pediatrics1471-24312020-04-012011810.1186/s12887-020-02047-3Natural history of gastroesophageal reflux in infancy: new data from a prospective cohortMarlène Curien-Chotard0Prévost Jantchou1Pediatric Unit, Besançon Teaching HospitalCHU Sainte-Justine. 3175 Côte Sainte CatherineAbstract Background Gastroesophageal reflux (GER) is common in infants. Gastroesophageal reflux disease (GERD) is defined as GER leading to troublesome symptoms that affect daily functioning and/or complications. This study is aimed at determining the prevalence and progression of GER and GERD in a cohort of healthy term infants from birth to 12 months old. Methods We conducted a prospective cohort study including all full-term living neonates born at Besançon Teaching Hospital, France. Parents completed a clinical report form and the Infant Gastroesophageal Reflux Questionnaire-Revised (I-GERQ-R) at 1, 3, 6, 10, and 12 months of age. GER was defined as score ≥ 1 to the first question with I-GERQ-R score < 16, and GERD as score ≥ 1 to the first question with I-GERQ-R score ≥ 16. Regurgitation was based on the answer to the first question of the I-GERQ-R as anything coming out of the mouth daily. Results 157/347 births were included (83 boys). The prevalence of regurgitation at least once a day was 45.7% overall. In total: 72, 69, 56, 18, and 13% of infants regurgitated at least once a day at 1, 3, 6, 10, and 12 months of age, respectively. Physiological GER affected 53, 59, 51, 16, and 12% of infants; GERD, 19, 9, 5, 2, and 2%, respectively. Two risk factors were identified: family history of GER and exposure to passive smoking. Treatment included dietary modification (14%) and pharmacotherapy (5%). Conclusion Physiological GER peaked at 3 months, GERD at 1 month. Most cases resolved on their own. GER and GERD are very common in the infant’s population and parents should be reassured/educated regarding symptoms, warning signs, and generally favorable prognosis. I-GERQ-R is useful to the clinical screening and follow up for GER and GERD.http://link.springer.com/article/10.1186/s12887-020-02047-3Gastroesophageal refluxGastroesophageal reflux diseaseInfancyInfantInfant Gastroesophageal Reflux Questionnaire RevisedI-GERQ-R |
| spellingShingle | Marlène Curien-Chotard Prévost Jantchou Natural history of gastroesophageal reflux in infancy: new data from a prospective cohort BMC Pediatrics Gastroesophageal reflux Gastroesophageal reflux disease Infancy Infant Infant Gastroesophageal Reflux Questionnaire Revised I-GERQ-R |
| title | Natural history of gastroesophageal reflux in infancy: new data from a prospective cohort |
| title_full | Natural history of gastroesophageal reflux in infancy: new data from a prospective cohort |
| title_fullStr | Natural history of gastroesophageal reflux in infancy: new data from a prospective cohort |
| title_full_unstemmed | Natural history of gastroesophageal reflux in infancy: new data from a prospective cohort |
| title_short | Natural history of gastroesophageal reflux in infancy: new data from a prospective cohort |
| title_sort | natural history of gastroesophageal reflux in infancy new data from a prospective cohort |
| topic | Gastroesophageal reflux Gastroesophageal reflux disease Infancy Infant Infant Gastroesophageal Reflux Questionnaire Revised I-GERQ-R |
| url | http://link.springer.com/article/10.1186/s12887-020-02047-3 |
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