Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin
Sleep is an essential component of overall human health but is so tightly regulated that when disrupted can cause or worsen certain ailments. An important part of this process is the presence of the well-known hormone, melatonin. This compound assists in the governing of sleep and circadian rhythms....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/10/3480 |
| _version_ | 1797513555392593920 |
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| author | Clayton Vasey Jennifer McBride Kayla Penta |
| author_facet | Clayton Vasey Jennifer McBride Kayla Penta |
| author_sort | Clayton Vasey |
| collection | DOAJ |
| description | Sleep is an essential component of overall human health but is so tightly regulated that when disrupted can cause or worsen certain ailments. An important part of this process is the presence of the well-known hormone, melatonin. This compound assists in the governing of sleep and circadian rhythms. Previous studies have postulated that dysregulation of melatonin rhythms is the driving force behind sleep and circadian disorders. A computer-aided search spanning the years of 2015–2020 using the search terms melatonin, circadian rhythm, disorder yielded 52 full text articles that were analyzed. We explored the mechanisms behind melatonin dysregulation and how it affects various disorders. Additionally, we examined associated therapeutic treatments including bright light therapy (BLT) and exogenous forms of melatonin. We found that over the past 5 years, melatonin has not been widely investigated in clinical studies thus there remains large gaps in its potential utilization as a therapy. |
| first_indexed | 2024-03-10T06:18:14Z |
| format | Article |
| id | doaj.art-70a2b50d4f2640c7b2ddeda38e69948f |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T06:18:14Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-70a2b50d4f2640c7b2ddeda38e69948f2023-11-22T19:29:13ZengMDPI AGNutrients2072-66432021-09-011310348010.3390/nu13103480Circadian Rhythm Dysregulation and Restoration: The Role of MelatoninClayton Vasey0Jennifer McBride1Kayla Penta2School of Pharmacy, College of Medicine, Lake Erie College of Osteopathic Medicine, Erie, PA 16509, USACOVID/Communicable Disease, Cabarrus Health Alliance, Kannapolis, NC 28081, USACollege of Medicine, Lake Erie College of Osteopathic Medicine, Elmira, NY 14901, USASleep is an essential component of overall human health but is so tightly regulated that when disrupted can cause or worsen certain ailments. An important part of this process is the presence of the well-known hormone, melatonin. This compound assists in the governing of sleep and circadian rhythms. Previous studies have postulated that dysregulation of melatonin rhythms is the driving force behind sleep and circadian disorders. A computer-aided search spanning the years of 2015–2020 using the search terms melatonin, circadian rhythm, disorder yielded 52 full text articles that were analyzed. We explored the mechanisms behind melatonin dysregulation and how it affects various disorders. Additionally, we examined associated therapeutic treatments including bright light therapy (BLT) and exogenous forms of melatonin. We found that over the past 5 years, melatonin has not been widely investigated in clinical studies thus there remains large gaps in its potential utilization as a therapy.https://www.mdpi.com/2072-6643/13/10/3480melatoninsleepcircadian rhythmbright light therapydelayed sleep phase disorder |
| spellingShingle | Clayton Vasey Jennifer McBride Kayla Penta Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin Nutrients melatonin sleep circadian rhythm bright light therapy delayed sleep phase disorder |
| title | Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin |
| title_full | Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin |
| title_fullStr | Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin |
| title_full_unstemmed | Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin |
| title_short | Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin |
| title_sort | circadian rhythm dysregulation and restoration the role of melatonin |
| topic | melatonin sleep circadian rhythm bright light therapy delayed sleep phase disorder |
| url | https://www.mdpi.com/2072-6643/13/10/3480 |
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