Rhein ameliorates transverse aortic constriction-induced cardiac hypertrophy via regulating STAT3 and p38 MAPK signaling pathways

Rhein ameliorates transverse aortic constriction-induced cardiac hypertrophy via regulating STAT3 and p38 MAPK signaling pathways

The progression from compensatory hypertrophy to heart failure is difficult to reverse, in part due to extracellular matrix fibrosis and continuous activation of abnormal signaling pathways. Although the anthraquinone rhein has been examined for its many biological properties, it is not clear whethe...

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Bibliographic Details
Main Authors: Run-Jing Li, Jia-Jia Xu, Zheng-Hao Zhang, Min-Wei Chen, Shi-Xiao Liu, Cui Yang, Yan-Ling Li, Ping Luo, Yi-Jiang Liu, Rong Tang, Zhong-Gui Shan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
rhein
transverse aortic constriction
cardiac hypertrophy
cardiac fibrosis
ERK phosphorylation
p38 MAPK
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.940574/full

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