Polyamine Biosynthetic Pathway as a Drug Target for Osteosarcoma Therapy

Polyamine Biosynthetic Pathway as a Drug Target for Osteosarcoma Therapy

Osteosarcoma (OS) is the most common bone tumor in children. Polyamines (PAs) are ubiquitous cations involved in many cell processes including tumor development, invasion and metastasis. In other pediatric cancer models, inhibition of the PA biosynthesis pathway with ornithine decarboxylase (ODC) in...

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Autors principals: Rebecca R. Weicht, Chad R. Schultz, Dirk Geerts, Katie L. Uhl, André S. Bachmann
Format: Article
Idioma:English
Publicat: MDPI AG 2018-08-01
Col·lecció:Medical Sciences
Matèries:
cell differentiation
DFMO
ornithine decarboxylase
osteosarcoma
polyamines
Accés en línia:http://www.mdpi.com/2076-3271/6/3/65

Internet

http://www.mdpi.com/2076-3271/6/3/65

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