Polyamine Biosynthetic Pathway as a Drug Target for Osteosarcoma Therapy

Polyamine Biosynthetic Pathway as a Drug Target for Osteosarcoma Therapy

Osteosarcoma (OS) is the most common bone tumor in children. Polyamines (PAs) are ubiquitous cations involved in many cell processes including tumor development, invasion and metastasis. In other pediatric cancer models, inhibition of the PA biosynthesis pathway with ornithine decarboxylase (ODC) in...

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Detalhes bibliográficos
Main Authors: Rebecca R. Weicht, Chad R. Schultz, Dirk Geerts, Katie L. Uhl, André S. Bachmann
Formato: Artigo
Idioma:English
Publicado em: MDPI AG 2018-08-01
Colecção:Medical Sciences
Assuntos:
cell differentiation
DFMO
ornithine decarboxylase
osteosarcoma
polyamines
Acesso em linha:http://www.mdpi.com/2076-3271/6/3/65

Internet

http://www.mdpi.com/2076-3271/6/3/65

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