Rosuvastatin: A Review of the Pharmacology and Clinical Effectiveness in Cardiovascular Disease
Rosuvastatin is a new generation HMG-CoA reductase inhibitor which exhibits some unique pharmacologic and pharmacokinetic properties. It has low extrahepatic tissue penetration, low potential for CYP3A4 interactions and substantial LDL-C lowering capacity and therefore has distinct advantages. We co...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2012-01-01
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| Series: | Clinical Medicine Insights: Cardiology |
| Online Access: | https://doi.org/10.4137/CMC.S4324 |
| _version_ | 1819111303114915840 |
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| author | Ahai Luvai Wycliffe Mbagaya Alistair S. Hall Julian H. Barth |
| author_facet | Ahai Luvai Wycliffe Mbagaya Alistair S. Hall Julian H. Barth |
| author_sort | Ahai Luvai |
| collection | DOAJ |
| description | Rosuvastatin is a new generation HMG-CoA reductase inhibitor which exhibits some unique pharmacologic and pharmacokinetic properties. It has low extrahepatic tissue penetration, low potential for CYP3A4 interactions and substantial LDL-C lowering capacity and therefore has distinct advantages. We conducted a Medline literature search to identify rosuvastatin papers published in English. In this review, we outline the pharmacology of rosuvastatin, highlighting its efficacy and safety. We also review the major clinical trials with reference to primary and secondary prevention, familial hypercholesterolaemia and comparison with other statins. Finally we address its place in clinical practice. |
| first_indexed | 2024-12-22T03:55:28Z |
| format | Article |
| id | doaj.art-70a3d3dce0b34250b99d173573d12d55 |
| institution | Directory Open Access Journal |
| issn | 1179-5468 |
| language | English |
| last_indexed | 2024-12-22T03:55:28Z |
| publishDate | 2012-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Cardiology |
| spelling | doaj.art-70a3d3dce0b34250b99d173573d12d552022-12-21T18:39:53ZengSAGE PublishingClinical Medicine Insights: Cardiology1179-54682012-01-01610.4137/CMC.S4324Rosuvastatin: A Review of the Pharmacology and Clinical Effectiveness in Cardiovascular DiseaseAhai Luvai0Wycliffe Mbagaya1Alistair S. Hall2Julian H. Barth3Department of Clinical Biochemistry, Leeds General Infirmary, LS1 3EX.Department of Clinical Biochemistry, Leeds General Infirmary, LS1 3EX.The Yorkshire Heart Centre, Leeds General Infirmary, LS1 3EX.Department of Clinical Biochemistry, Leeds General Infirmary, LS1 3EX.Rosuvastatin is a new generation HMG-CoA reductase inhibitor which exhibits some unique pharmacologic and pharmacokinetic properties. It has low extrahepatic tissue penetration, low potential for CYP3A4 interactions and substantial LDL-C lowering capacity and therefore has distinct advantages. We conducted a Medline literature search to identify rosuvastatin papers published in English. In this review, we outline the pharmacology of rosuvastatin, highlighting its efficacy and safety. We also review the major clinical trials with reference to primary and secondary prevention, familial hypercholesterolaemia and comparison with other statins. Finally we address its place in clinical practice.https://doi.org/10.4137/CMC.S4324 |
| spellingShingle | Ahai Luvai Wycliffe Mbagaya Alistair S. Hall Julian H. Barth Rosuvastatin: A Review of the Pharmacology and Clinical Effectiveness in Cardiovascular Disease Clinical Medicine Insights: Cardiology |
| title | Rosuvastatin: A Review of the Pharmacology and Clinical Effectiveness in Cardiovascular Disease |
| title_full | Rosuvastatin: A Review of the Pharmacology and Clinical Effectiveness in Cardiovascular Disease |
| title_fullStr | Rosuvastatin: A Review of the Pharmacology and Clinical Effectiveness in Cardiovascular Disease |
| title_full_unstemmed | Rosuvastatin: A Review of the Pharmacology and Clinical Effectiveness in Cardiovascular Disease |
| title_short | Rosuvastatin: A Review of the Pharmacology and Clinical Effectiveness in Cardiovascular Disease |
| title_sort | rosuvastatin a review of the pharmacology and clinical effectiveness in cardiovascular disease |
| url | https://doi.org/10.4137/CMC.S4324 |
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