| Summary: | Pterjium is an ocular surface disorder and is a pathologic result of
corneal invasion of the fibro-vascular proliferation of the bulb conjunctiva in
the region corresponding to the lid space. Pterjium is a disease with high
rates of recurrence after surgery. Nowadays, along with several new techniques
that are used to prevent recurrence, antineoplastics are also used to stop the
growth. Various growth factors and mediators, like some neoplasms, have been
found to be effective in pterygium growth, invasion and relapse. In addition to
growth factors such as stem cell factor and VEGF, an increase in histamine,
carbonic anhydrase activity, in number of eph B4, and in nestin release was
found while a decrease in IGFBP3 release was found. Studies are currently
underway to stop the growth of pterygium and prevent recurrence.
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