Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention
Sensory processing dysfunction (SPD) is characterized by a behaviorally observed difference in the response to sensory information from the environment. While the cerebellum is involved in normal sensory processing, it has not yet been examined in SPD. Diffusion tensor imaging scans of children with...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-02-01
|
| Series: | Frontiers in Psychology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2020.618436/full |
| _version_ | 1829487087208890368 |
|---|---|
| author | Anisha Narayan Anisha Narayan Mikaela A. Rowe Mikaela A. Rowe Eva M. Palacios Jamie Wren-Jarvis Ioanna Bourla Molly Gerdes Annie Brandes-Aitken Shivani S. Desai Elysa J. Marco Elysa J. Marco Pratik Mukherjee Pratik Mukherjee |
| author_facet | Anisha Narayan Anisha Narayan Mikaela A. Rowe Mikaela A. Rowe Eva M. Palacios Jamie Wren-Jarvis Ioanna Bourla Molly Gerdes Annie Brandes-Aitken Shivani S. Desai Elysa J. Marco Elysa J. Marco Pratik Mukherjee Pratik Mukherjee |
| author_sort | Anisha Narayan |
| collection | DOAJ |
| description | Sensory processing dysfunction (SPD) is characterized by a behaviorally observed difference in the response to sensory information from the environment. While the cerebellum is involved in normal sensory processing, it has not yet been examined in SPD. Diffusion tensor imaging scans of children with SPD (n = 42) and typically developing controls (TDC; n = 39) were compared for fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) across the following cerebellar tracts: the middle cerebellar peduncles (MCP), superior cerebellar peduncles (SCP), and cerebral peduncles (CP). Compared to TDC, children with SPD show reduced microstructural integrity of the SCP and MCP, characterized by reduced FA and increased MD and RD, which correlates with abnormal auditory behavior, multisensory integration, and attention, but not tactile behavior or direct measures of auditory discrimination. In contradistinction, decreased CP microstructural integrity in SPD correlates with abnormal tactile and auditory behavior and direct measures of auditory discrimination, but not multisensory integration or attention. Hence, altered cerebellar white matter organization is associated with complex sensory behavior and attention in SPD, which prompts further consideration of diagnostic measures and treatments to better serve affected individuals. |
| first_indexed | 2024-12-14T23:20:27Z |
| format | Article |
| id | doaj.art-70a499a460de4280b4ca10a90b303cda |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-12-14T23:20:27Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-70a499a460de4280b4ca10a90b303cda2022-12-21T22:43:58ZengFrontiers Media S.A.Frontiers in Psychology1664-10782021-02-011110.3389/fpsyg.2020.618436618436Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and AttentionAnisha Narayan0Anisha Narayan1Mikaela A. Rowe2Mikaela A. Rowe3Eva M. Palacios4Jamie Wren-Jarvis5Ioanna Bourla6Molly Gerdes7Annie Brandes-Aitken8Shivani S. Desai9Elysa J. Marco10Elysa J. Marco11Pratik Mukherjee12Pratik Mukherjee13Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Medicine, Tulane University School of Medicine, New Orleans, LA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesCortica Healthcare, San Rafael, CA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesCortica Healthcare, San Rafael, CA, United StatesDepartment of Neurology, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesCortica Healthcare, San Rafael, CA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United StatesSensory processing dysfunction (SPD) is characterized by a behaviorally observed difference in the response to sensory information from the environment. While the cerebellum is involved in normal sensory processing, it has not yet been examined in SPD. Diffusion tensor imaging scans of children with SPD (n = 42) and typically developing controls (TDC; n = 39) were compared for fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) across the following cerebellar tracts: the middle cerebellar peduncles (MCP), superior cerebellar peduncles (SCP), and cerebral peduncles (CP). Compared to TDC, children with SPD show reduced microstructural integrity of the SCP and MCP, characterized by reduced FA and increased MD and RD, which correlates with abnormal auditory behavior, multisensory integration, and attention, but not tactile behavior or direct measures of auditory discrimination. In contradistinction, decreased CP microstructural integrity in SPD correlates with abnormal tactile and auditory behavior and direct measures of auditory discrimination, but not multisensory integration or attention. Hence, altered cerebellar white matter organization is associated with complex sensory behavior and attention in SPD, which prompts further consideration of diagnostic measures and treatments to better serve affected individuals.https://www.frontiersin.org/articles/10.3389/fpsyg.2020.618436/fullsensory processingcerebellumneurodevelopmental disordersdiffusion tensor imagingconnectivitywhite matter |
| spellingShingle | Anisha Narayan Anisha Narayan Mikaela A. Rowe Mikaela A. Rowe Eva M. Palacios Jamie Wren-Jarvis Ioanna Bourla Molly Gerdes Annie Brandes-Aitken Shivani S. Desai Elysa J. Marco Elysa J. Marco Pratik Mukherjee Pratik Mukherjee Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention Frontiers in Psychology sensory processing cerebellum neurodevelopmental disorders diffusion tensor imaging connectivity white matter |
| title | Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention |
| title_full | Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention |
| title_fullStr | Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention |
| title_full_unstemmed | Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention |
| title_short | Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention |
| title_sort | altered cerebellar white matter in sensory processing dysfunction is associated with impaired multisensory integration and attention |
| topic | sensory processing cerebellum neurodevelopmental disorders diffusion tensor imaging connectivity white matter |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2020.618436/full |
| work_keys_str_mv | AT anishanarayan alteredcerebellarwhitematterinsensoryprocessingdysfunctionisassociatedwithimpairedmultisensoryintegrationandattention AT anishanarayan alteredcerebellarwhitematterinsensoryprocessingdysfunctionisassociatedwithimpairedmultisensoryintegrationandattention AT mikaelaarowe alteredcerebellarwhitematterinsensoryprocessingdysfunctionisassociatedwithimpairedmultisensoryintegrationandattention AT mikaelaarowe alteredcerebellarwhitematterinsensoryprocessingdysfunctionisassociatedwithimpairedmultisensoryintegrationandattention AT evampalacios alteredcerebellarwhitematterinsensoryprocessingdysfunctionisassociatedwithimpairedmultisensoryintegrationandattention AT jamiewrenjarvis alteredcerebellarwhitematterinsensoryprocessingdysfunctionisassociatedwithimpairedmultisensoryintegrationandattention AT ioannabourla alteredcerebellarwhitematterinsensoryprocessingdysfunctionisassociatedwithimpairedmultisensoryintegrationandattention AT mollygerdes alteredcerebellarwhitematterinsensoryprocessingdysfunctionisassociatedwithimpairedmultisensoryintegrationandattention AT anniebrandesaitken alteredcerebellarwhitematterinsensoryprocessingdysfunctionisassociatedwithimpairedmultisensoryintegrationandattention AT shivanisdesai alteredcerebellarwhitematterinsensoryprocessingdysfunctionisassociatedwithimpairedmultisensoryintegrationandattention AT elysajmarco alteredcerebellarwhitematterinsensoryprocessingdysfunctionisassociatedwithimpairedmultisensoryintegrationandattention AT elysajmarco alteredcerebellarwhitematterinsensoryprocessingdysfunctionisassociatedwithimpairedmultisensoryintegrationandattention AT pratikmukherjee alteredcerebellarwhitematterinsensoryprocessingdysfunctionisassociatedwithimpairedmultisensoryintegrationandattention AT pratikmukherjee alteredcerebellarwhitematterinsensoryprocessingdysfunctionisassociatedwithimpairedmultisensoryintegrationandattention |