Epidemiology and clinical features of SARS‐CoV‐2 infection in hospitalized children across four waves in Hungary: A retrospective, comparative study from March 2020 to December 2021
Abstract Background and Aims From 2019 till the present, infections induced by the novel coronavirus and its mutations have posed a new challenge for healthcare. However, comparative studies on pediatric infections throughout waves are few. During four different pandemic waves, we intended to invest...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-11-01
|
| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.937 |
| _version_ | 1797772307574292480 |
|---|---|
| author | Andrea T. Takács Mátyás Bukva Gabriella Gavallér Katalin Kapus Mária Rózsa Boglárka Bán‐Gagyi Mária Sinkó Dániel Szűcs Gabriella Terhes Csaba Bereczki |
| author_facet | Andrea T. Takács Mátyás Bukva Gabriella Gavallér Katalin Kapus Mária Rózsa Boglárka Bán‐Gagyi Mária Sinkó Dániel Szűcs Gabriella Terhes Csaba Bereczki |
| author_sort | Andrea T. Takács |
| collection | DOAJ |
| description | Abstract Background and Aims From 2019 till the present, infections induced by the novel coronavirus and its mutations have posed a new challenge for healthcare. However, comparative studies on pediatric infections throughout waves are few. During four different pandemic waves, we intended to investigate the clinical and epidemiological characteristic of the pediatric population hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) virus infection. Methods Between March 2020 and December 2021, we performed our retrospective research on children infected with the SARS‐CoV‐2 virus at the University of Szeged. We analyzed the data of all patients who required hospitalization due to positive results of SARS‐CoV‐2 tests (Nucleic Acid Amplification Test or rapid antigen test). Data analysis included demographic data, medical history, clinical findings, length of hospitalization, and complications, using medical records. Results In this study, data from 358 coronavirus‐infected children were analyzed. The most affected age group was children over 1 month and under 1 year (30.2%). The highest number of cases was recorded in the fourth wave (53.6%). Fever (65.6%), cough (51.4%), nasal discharge (35.3%), nausea and vomiting (31.3%), and decreased oral intake (28.9%) were the most common symptoms. The most common complications were dehydration (50.5%), pneumonia (14.9%), and bronchitis/bronchiolitis (14.5%). Based on RR values, there are considerable differences in the prevalence of the symptoms and complications between the different age groups and waves. Cox proportional hazard model analyzes showed that fever and tachypnoea had a relevant effect on days to recovery. Conclusions We found trends similar to those previously published, overall statistics. The proportion of children requiring hospitalization varied from wave to wave, with the fourth wave affecting the Hungarian child population the most. Our findings suggest that hospitalization time is unrelated to age, but that certain symptoms (fever and tachypnoea) are associated with longer hospitalization. The onset of certain symptoms may differ by age group. |
| first_indexed | 2024-03-12T21:50:11Z |
| format | Article |
| id | doaj.art-70a62735c413434c9615349e54b10209 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-12T21:50:11Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-70a62735c413434c9615349e54b102092023-07-26T04:31:46ZengWileyHealth Science Reports2398-88352022-11-0156n/an/a10.1002/hsr2.937Epidemiology and clinical features of SARS‐CoV‐2 infection in hospitalized children across four waves in Hungary: A retrospective, comparative study from March 2020 to December 2021Andrea T. Takács0Mátyás Bukva1Gabriella Gavallér2Katalin Kapus3Mária Rózsa4Boglárka Bán‐Gagyi5Mária Sinkó6Dániel Szűcs7Gabriella Terhes8Csaba Bereczki9Department of Paediatrics and Paediatric Health Center University of Szeged Szeged HungaryLaboratory of Microscopic Image Analysis and Machine Learning, Biological Research Centre, Eötvös Loránd Research Network Institute of Biochemistry Szeged HungaryDepartment of Paediatrics and Paediatric Health Center University of Szeged Szeged HungaryDepartment of Paediatrics and Paediatric Health Center University of Szeged Szeged HungaryDepartment of Paediatrics and Paediatric Health Center University of Szeged Szeged HungaryDepartment of Paediatrics and Paediatric Health Center University of Szeged Szeged HungaryDepartment of Paediatrics and Paediatric Health Center University of Szeged Szeged HungaryDepartment of Paediatrics and Paediatric Health Center University of Szeged Szeged HungaryDepartment of Medical Microbiology University of Szeged Szeged HungaryDepartment of Paediatrics and Paediatric Health Center University of Szeged Szeged HungaryAbstract Background and Aims From 2019 till the present, infections induced by the novel coronavirus and its mutations have posed a new challenge for healthcare. However, comparative studies on pediatric infections throughout waves are few. During four different pandemic waves, we intended to investigate the clinical and epidemiological characteristic of the pediatric population hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) virus infection. Methods Between March 2020 and December 2021, we performed our retrospective research on children infected with the SARS‐CoV‐2 virus at the University of Szeged. We analyzed the data of all patients who required hospitalization due to positive results of SARS‐CoV‐2 tests (Nucleic Acid Amplification Test or rapid antigen test). Data analysis included demographic data, medical history, clinical findings, length of hospitalization, and complications, using medical records. Results In this study, data from 358 coronavirus‐infected children were analyzed. The most affected age group was children over 1 month and under 1 year (30.2%). The highest number of cases was recorded in the fourth wave (53.6%). Fever (65.6%), cough (51.4%), nasal discharge (35.3%), nausea and vomiting (31.3%), and decreased oral intake (28.9%) were the most common symptoms. The most common complications were dehydration (50.5%), pneumonia (14.9%), and bronchitis/bronchiolitis (14.5%). Based on RR values, there are considerable differences in the prevalence of the symptoms and complications between the different age groups and waves. Cox proportional hazard model analyzes showed that fever and tachypnoea had a relevant effect on days to recovery. Conclusions We found trends similar to those previously published, overall statistics. The proportion of children requiring hospitalization varied from wave to wave, with the fourth wave affecting the Hungarian child population the most. Our findings suggest that hospitalization time is unrelated to age, but that certain symptoms (fever and tachypnoea) are associated with longer hospitalization. The onset of certain symptoms may differ by age group.https://doi.org/10.1002/hsr2.937childrenCOVID‐19hospitalization waveSARS‐CoV‐2 infection |
| spellingShingle | Andrea T. Takács Mátyás Bukva Gabriella Gavallér Katalin Kapus Mária Rózsa Boglárka Bán‐Gagyi Mária Sinkó Dániel Szűcs Gabriella Terhes Csaba Bereczki Epidemiology and clinical features of SARS‐CoV‐2 infection in hospitalized children across four waves in Hungary: A retrospective, comparative study from March 2020 to December 2021 Health Science Reports children COVID‐19 hospitalization wave SARS‐CoV‐2 infection |
| title | Epidemiology and clinical features of SARS‐CoV‐2 infection in hospitalized children across four waves in Hungary: A retrospective, comparative study from March 2020 to December 2021 |
| title_full | Epidemiology and clinical features of SARS‐CoV‐2 infection in hospitalized children across four waves in Hungary: A retrospective, comparative study from March 2020 to December 2021 |
| title_fullStr | Epidemiology and clinical features of SARS‐CoV‐2 infection in hospitalized children across four waves in Hungary: A retrospective, comparative study from March 2020 to December 2021 |
| title_full_unstemmed | Epidemiology and clinical features of SARS‐CoV‐2 infection in hospitalized children across four waves in Hungary: A retrospective, comparative study from March 2020 to December 2021 |
| title_short | Epidemiology and clinical features of SARS‐CoV‐2 infection in hospitalized children across four waves in Hungary: A retrospective, comparative study from March 2020 to December 2021 |
| title_sort | epidemiology and clinical features of sars cov 2 infection in hospitalized children across four waves in hungary a retrospective comparative study from march 2020 to december 2021 |
| topic | children COVID‐19 hospitalization wave SARS‐CoV‐2 infection |
| url | https://doi.org/10.1002/hsr2.937 |
| work_keys_str_mv | AT andreattakacs epidemiologyandclinicalfeaturesofsarscov2infectioninhospitalizedchildrenacrossfourwavesinhungaryaretrospectivecomparativestudyfrommarch2020todecember2021 AT matyasbukva epidemiologyandclinicalfeaturesofsarscov2infectioninhospitalizedchildrenacrossfourwavesinhungaryaretrospectivecomparativestudyfrommarch2020todecember2021 AT gabriellagavaller epidemiologyandclinicalfeaturesofsarscov2infectioninhospitalizedchildrenacrossfourwavesinhungaryaretrospectivecomparativestudyfrommarch2020todecember2021 AT katalinkapus epidemiologyandclinicalfeaturesofsarscov2infectioninhospitalizedchildrenacrossfourwavesinhungaryaretrospectivecomparativestudyfrommarch2020todecember2021 AT mariarozsa epidemiologyandclinicalfeaturesofsarscov2infectioninhospitalizedchildrenacrossfourwavesinhungaryaretrospectivecomparativestudyfrommarch2020todecember2021 AT boglarkabangagyi epidemiologyandclinicalfeaturesofsarscov2infectioninhospitalizedchildrenacrossfourwavesinhungaryaretrospectivecomparativestudyfrommarch2020todecember2021 AT mariasinko epidemiologyandclinicalfeaturesofsarscov2infectioninhospitalizedchildrenacrossfourwavesinhungaryaretrospectivecomparativestudyfrommarch2020todecember2021 AT danielszucs epidemiologyandclinicalfeaturesofsarscov2infectioninhospitalizedchildrenacrossfourwavesinhungaryaretrospectivecomparativestudyfrommarch2020todecember2021 AT gabriellaterhes epidemiologyandclinicalfeaturesofsarscov2infectioninhospitalizedchildrenacrossfourwavesinhungaryaretrospectivecomparativestudyfrommarch2020todecember2021 AT csababereczki epidemiologyandclinicalfeaturesofsarscov2infectioninhospitalizedchildrenacrossfourwavesinhungaryaretrospectivecomparativestudyfrommarch2020todecember2021 |