Nitric oxide and mitochondria in metabolic syndrome
Metabolic syndrome (MS) is a cluster of metabolic disorders that collectively increase the risk of cardiovascular disease. Nitric oxide (NO) plays a crucial role in the pathogeneses of MS components and is involved in different mitochondrial signaling pathways that control respiration and apoptosis....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-02-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00020/full |
| _version_ | 1819171397996380160 |
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| author | Larisa eLitvinova Dmitriy N. Atochin Nikolai eFattakhov Mariia eVasilenko Pavel eZatolokin Elena eKirienkova |
| author_facet | Larisa eLitvinova Dmitriy N. Atochin Nikolai eFattakhov Mariia eVasilenko Pavel eZatolokin Elena eKirienkova |
| author_sort | Larisa eLitvinova |
| collection | DOAJ |
| description | Metabolic syndrome (MS) is a cluster of metabolic disorders that collectively increase the risk of cardiovascular disease. Nitric oxide (NO) plays a crucial role in the pathogeneses of MS components and is involved in different mitochondrial signaling pathways that control respiration and apoptosis. The present review summarizes the recent information regarding the interrelations of mitochondria and NO in MS. Changes in the activities of different NO synthase isoforms lead to the formation of metabolic disorders and therefore are highlighted here. Reduced endothelial NOS activity and NO bioavailability, as the main factors underlying the endothelial dysfunction that occurs in MS, are discussed in this review in relation to mitochondrial dysfunction. We also focus on potential therapeutic strategies involving NO signaling pathways that can be used to treat patients with metabolic disorders associated with mitochondrial dysfunction. The article may help researchers develop new approaches for the diagnosis, prevention and treatment of MS. |
| first_indexed | 2024-12-22T19:50:39Z |
| format | Article |
| id | doaj.art-70a9134f531346bc91f7fe8408014b63 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-22T19:50:39Z |
| publishDate | 2015-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-70a9134f531346bc91f7fe8408014b632022-12-21T18:14:34ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2015-02-01610.3389/fphys.2015.00020120368Nitric oxide and mitochondria in metabolic syndromeLarisa eLitvinova0Dmitriy N. Atochin1Nikolai eFattakhov2Mariia eVasilenko3Pavel eZatolokin4Elena eKirienkova5Immanuel Kant Baltic Federal UniversityMassachusetts General HospitaImmanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityRegional Clinical Hospital of the Kaliningrad RegionImmanuel Kant Baltic Federal UniversityMetabolic syndrome (MS) is a cluster of metabolic disorders that collectively increase the risk of cardiovascular disease. Nitric oxide (NO) plays a crucial role in the pathogeneses of MS components and is involved in different mitochondrial signaling pathways that control respiration and apoptosis. The present review summarizes the recent information regarding the interrelations of mitochondria and NO in MS. Changes in the activities of different NO synthase isoforms lead to the formation of metabolic disorders and therefore are highlighted here. Reduced endothelial NOS activity and NO bioavailability, as the main factors underlying the endothelial dysfunction that occurs in MS, are discussed in this review in relation to mitochondrial dysfunction. We also focus on potential therapeutic strategies involving NO signaling pathways that can be used to treat patients with metabolic disorders associated with mitochondrial dysfunction. The article may help researchers develop new approaches for the diagnosis, prevention and treatment of MS.http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00020/fullMitochondriaNitric OxideObesitymetabolic syndrometype 2 diabetesMitochondrial dysfunction |
| spellingShingle | Larisa eLitvinova Dmitriy N. Atochin Nikolai eFattakhov Mariia eVasilenko Pavel eZatolokin Elena eKirienkova Nitric oxide and mitochondria in metabolic syndrome Frontiers in Physiology Mitochondria Nitric Oxide Obesity metabolic syndrome type 2 diabetes Mitochondrial dysfunction |
| title | Nitric oxide and mitochondria in metabolic syndrome |
| title_full | Nitric oxide and mitochondria in metabolic syndrome |
| title_fullStr | Nitric oxide and mitochondria in metabolic syndrome |
| title_full_unstemmed | Nitric oxide and mitochondria in metabolic syndrome |
| title_short | Nitric oxide and mitochondria in metabolic syndrome |
| title_sort | nitric oxide and mitochondria in metabolic syndrome |
| topic | Mitochondria Nitric Oxide Obesity metabolic syndrome type 2 diabetes Mitochondrial dysfunction |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00020/full |
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