Inhibition of Histone Deacetylase (HDAC) Enhances Checkpoint Blockade Efficacy by Rendering Bladder Cancer Cells Visible for T Cell-Mediated Destruction

Inhibition of Histone Deacetylase (HDAC) Enhances Checkpoint Blockade Efficacy by Rendering Bladder Cancer Cells Visible for T Cell-Mediated Destruction

Inhibitory checkpoint blockade therapy is an immunomodulatory strategy that results in the restoration of T cell functions, and its efficacy depends on the recognition of tumor cells for destruction. Considering the factors at play, one could propose that anti-tumor responses will not occur if tumor...

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Bibliographic Details
Main Authors: Brianna Burke, Catherine Eden, Cynthia Perez, Alex Belshoff, Spencer Hart, Lourdes Plaza-Rojas, Michael Delos Reyes, Kushal Prajapati, Christina Voelkel-Johnson, Elizabeth Henry, Gopal Gupta, José Guevara-Patiño
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
HDAC
bladder cancer
T cells
NKG2D
anti-PD1
immune evasion
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00699/full

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