The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for pulmonary transit and egress from the lymph nodes

The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for pulmonary transit and egress from the lymph nodes

Rap1-GTPase activates integrins and plays an indispensable role in lymphocyte trafficking, but the importance of Rap1 inactivation in this process remains unknown. Here we identified the Rap1-inactivating proteins Rasa3 and Sipa1 as critical regulators of lymphocyte trafficking. The loss of Rasa3 an...

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Bibliographic Details
Main Authors: Shunsuke Horitani, Yoshihiro Ueda, Yuji Kamioka, Naoyuki Kondo, Yoshiki Ikeda, Makoto Naganuma, Tatsuo Kinashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
Rap-GAP
T cell trafficking
integrin
lung
Rap1
LFA1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1234747/full

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