Epithelium-on photorefractive intrastromal cross-linking (PiXL) for reduction of low myopia
Wee Kiak Lim,1,2 Zhi Da Soh,1 Harold Kah Yen Choi,1 Julian Thiam Siew Theng1,3 1Eagle Eye Centre, Mount Alvernia Hospital, 2Department of Ophthalmology, Tan Tock Seng Hospital, 3Department of Ophthalmology, Khoo Teck Puat Hospital, Singapore Purpose: To report the 9–12-month outcomes of...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-06-01
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| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/epithelium-on-photorefractive-intrastromal-cross-linking-pixl-for-redu-peer-reviewed-article-OPTH |
| _version_ | 1818844416077463552 |
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| author | Lim WK Soh ZD Choi HKY Theng JTS |
| author_facet | Lim WK Soh ZD Choi HKY Theng JTS |
| author_sort | Lim WK |
| collection | DOAJ |
| description | Wee Kiak Lim,1,2 Zhi Da Soh,1 Harold Kah Yen Choi,1 Julian Thiam Siew Theng1,3 1Eagle Eye Centre, Mount Alvernia Hospital, 2Department of Ophthalmology, Tan Tock Seng Hospital, 3Department of Ophthalmology, Khoo Teck Puat Hospital, Singapore Purpose: To report the 9–12-month outcomes of a novel procedure for reduction of low myopia through epithelium-on photorefractive intrastromal cross-linking (PiXL) with customized control of topographic distribution of ultraviolet (UV)-fluence. Method: Myopic patients with normal (non-ectatic) corneas underwent the PiXL procedure for reduction of low myopia. PiXL treatments were delivered through selective application of UVA light based on the refractive error of each patient. Clinical evaluation included safety (corrected distance visual acuity, endothelial cell count, central corneal thickness, anterior ocular health) and efficacy (uncorrected distance visual acuity, manifest refraction, K-mean) examinations. In addition, a patient satisfaction survey was conducted at 9 months post-procedure to evaluate patients’ subjective experience with the procedure. Results: Fourteen myopic eyes (mean manifest refraction spherical equivalent –1.62±0.6D; range –0.75 to –2.65D) of 8 subjects (mean age 30 years old; range 24–51 years old) were enrolled in the study. At 12 months post-procedure, a mean manifest refraction spherical equivalent reduction of 0.72±0.43D (P<0.001) was observed, with a corresponding gain in uncorrected visual acuity of 0.25 logMAR and mean K-mean flattening of 0.47±0.46D. All patients achieved best corrected visual acuity of 20/20 or better from 1 month onward. There were no cases of ocular infection or secondary changes to the crystalline lens and retina due to UV exposure, while transient corneal haze subsided gradually. Conclusion: The epithelium-on PiXL procedure was safe and effective in reducing myopic refractive error in this study with up to 12 months follow-up. Early results of this novel application of collagen cross-linking are encouraging but longer-term data in larger studies are required. Precis: This paper serves to introduce and report the early clinical results of epithelium-on PiXL, a novel application of cornea cross-linking, in reducing low myopia in Asian eyes, which are under-represented in studies of similar design. Keywords: PiXL, cornea collagen cross-linking, low myopia correction |
| first_indexed | 2024-12-19T05:13:25Z |
| format | Article |
| id | doaj.art-70aa5a4b3b15443f8e8681e85d981a48 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-19T05:13:25Z |
| publishDate | 2017-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-70aa5a4b3b15443f8e8681e85d981a482022-12-21T20:34:45ZengDove Medical PressClinical Ophthalmology1177-54832017-06-01Volume 111205121133469Epithelium-on photorefractive intrastromal cross-linking (PiXL) for reduction of low myopiaLim WKSoh ZDChoi HKYTheng JTSWee Kiak Lim,1,2 Zhi Da Soh,1 Harold Kah Yen Choi,1 Julian Thiam Siew Theng1,3 1Eagle Eye Centre, Mount Alvernia Hospital, 2Department of Ophthalmology, Tan Tock Seng Hospital, 3Department of Ophthalmology, Khoo Teck Puat Hospital, Singapore Purpose: To report the 9–12-month outcomes of a novel procedure for reduction of low myopia through epithelium-on photorefractive intrastromal cross-linking (PiXL) with customized control of topographic distribution of ultraviolet (UV)-fluence. Method: Myopic patients with normal (non-ectatic) corneas underwent the PiXL procedure for reduction of low myopia. PiXL treatments were delivered through selective application of UVA light based on the refractive error of each patient. Clinical evaluation included safety (corrected distance visual acuity, endothelial cell count, central corneal thickness, anterior ocular health) and efficacy (uncorrected distance visual acuity, manifest refraction, K-mean) examinations. In addition, a patient satisfaction survey was conducted at 9 months post-procedure to evaluate patients’ subjective experience with the procedure. Results: Fourteen myopic eyes (mean manifest refraction spherical equivalent –1.62±0.6D; range –0.75 to –2.65D) of 8 subjects (mean age 30 years old; range 24–51 years old) were enrolled in the study. At 12 months post-procedure, a mean manifest refraction spherical equivalent reduction of 0.72±0.43D (P<0.001) was observed, with a corresponding gain in uncorrected visual acuity of 0.25 logMAR and mean K-mean flattening of 0.47±0.46D. All patients achieved best corrected visual acuity of 20/20 or better from 1 month onward. There were no cases of ocular infection or secondary changes to the crystalline lens and retina due to UV exposure, while transient corneal haze subsided gradually. Conclusion: The epithelium-on PiXL procedure was safe and effective in reducing myopic refractive error in this study with up to 12 months follow-up. Early results of this novel application of collagen cross-linking are encouraging but longer-term data in larger studies are required. Precis: This paper serves to introduce and report the early clinical results of epithelium-on PiXL, a novel application of cornea cross-linking, in reducing low myopia in Asian eyes, which are under-represented in studies of similar design. Keywords: PiXL, cornea collagen cross-linking, low myopia correction https://www.dovepress.com/epithelium-on-photorefractive-intrastromal-cross-linking-pixl-for-redu-peer-reviewed-article-OPTHPiXLCornea Collagen Cross-linkingLow myopia correction |
| spellingShingle | Lim WK Soh ZD Choi HKY Theng JTS Epithelium-on photorefractive intrastromal cross-linking (PiXL) for reduction of low myopia Clinical Ophthalmology PiXL Cornea Collagen Cross-linking Low myopia correction |
| title | Epithelium-on photorefractive intrastromal cross-linking (PiXL) for reduction of low myopia |
| title_full | Epithelium-on photorefractive intrastromal cross-linking (PiXL) for reduction of low myopia |
| title_fullStr | Epithelium-on photorefractive intrastromal cross-linking (PiXL) for reduction of low myopia |
| title_full_unstemmed | Epithelium-on photorefractive intrastromal cross-linking (PiXL) for reduction of low myopia |
| title_short | Epithelium-on photorefractive intrastromal cross-linking (PiXL) for reduction of low myopia |
| title_sort | epithelium on photorefractive intrastromal cross linking pixl for reduction of low myopia |
| topic | PiXL Cornea Collagen Cross-linking Low myopia correction |
| url | https://www.dovepress.com/epithelium-on-photorefractive-intrastromal-cross-linking-pixl-for-redu-peer-reviewed-article-OPTH |
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