Absorbed dose assessment due to proton and neutron particles in tumoral and healthy tissues of liver in proton-therapy using Monte Carlo method
Proton therapy is one of the best methods of treatment for liver cancer. In this research, the main parts of proton therapy system, with passive scattering nozzle, including range-modulating wheel, energy-compensated contoured scatterer and collimators were simulated. Then the proton absorbed dose i...
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| Format: | Article |
| Language: | English |
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Isfahan University of Technology
2022-02-01
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| Series: | Iranian Journal of Physics Research |
| Subjects: | |
| Online Access: | http://ijpr.iut.ac.ir/article_1760_cffc27990266c2c6effd90b544f8b8a7.pdf |
| _version_ | 1797996833942798336 |
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| author | S Z Moayedian A Karimian MH Alamatsaz |
| author_facet | S Z Moayedian A Karimian MH Alamatsaz |
| author_sort | S Z Moayedian |
| collection | DOAJ |
| description | Proton therapy is one of the best methods of treatment for liver cancer. In this research, the main parts of proton therapy system, with passive scattering nozzle, including range-modulating wheel, energy-compensated contoured scatterer and collimators were simulated. Then the proton absorbed dose in healthy and tumoral tissues was calculated by simulating the proton therapy of liver tumors. Furthermore the secondary neutron dose, that increases the risk of secondary cancers, was calculated. For this purpose, the neutron equivalent absorbed dose in tumor and healthy tissues were calculated. Furthermore, the MIRD phantom was located in front of the output of the proton therapy system. By simulating the proton therapy for tumor in depth of 11 cm in the liver with mean source energy of 200 MeV, the absorbed dose of proton in tumor estimated as 3.32 × 10-12 Gy/particle that is 7.26 times more than proton dose in healthy parts of liver. This ratio showed that tumor absorbs the maximum dose, while the healthy tissue absorbs the minimum dose. In the next step, the same procedure was done with mean source energy of 180 MeV for tumor in depth of 6 Cm. According to the results, the proton absorbed dose in tumor was 1.94 × 10-12 Gy/particle that is 9 times more than proton absorbed dose in healthy tissue. Also the maximum neutron equivalent absorbed dose in healthy tissue is of the order of 10-14 Sv that can be ignorable in comparison with proton treatment effects of proton therapy. |
| first_indexed | 2024-04-11T10:23:46Z |
| format | Article |
| id | doaj.art-70aa67a03082484e89cb504ed89993cc |
| institution | Directory Open Access Journal |
| issn | 1682-6957 2345-3664 |
| language | English |
| last_indexed | 2024-04-11T10:23:46Z |
| publishDate | 2022-02-01 |
| publisher | Isfahan University of Technology |
| record_format | Article |
| series | Iranian Journal of Physics Research |
| spelling | doaj.art-70aa67a03082484e89cb504ed89993cc2022-12-22T04:29:40ZengIsfahan University of TechnologyIranian Journal of Physics Research1682-69572345-36642022-02-0121482183210.47176/ijpr.21.4.211751760Absorbed dose assessment due to proton and neutron particles in tumoral and healthy tissues of liver in proton-therapy using Monte Carlo methodS Z Moayedian0A Karimian1MH Alamatsaz2Department of Physics, Isfahan University of Technology, Isfahan, IranDepartment of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, IranDepartment of Physics, Isfahan University of Technology, Isfahan, IranProton therapy is one of the best methods of treatment for liver cancer. In this research, the main parts of proton therapy system, with passive scattering nozzle, including range-modulating wheel, energy-compensated contoured scatterer and collimators were simulated. Then the proton absorbed dose in healthy and tumoral tissues was calculated by simulating the proton therapy of liver tumors. Furthermore the secondary neutron dose, that increases the risk of secondary cancers, was calculated. For this purpose, the neutron equivalent absorbed dose in tumor and healthy tissues were calculated. Furthermore, the MIRD phantom was located in front of the output of the proton therapy system. By simulating the proton therapy for tumor in depth of 11 cm in the liver with mean source energy of 200 MeV, the absorbed dose of proton in tumor estimated as 3.32 × 10-12 Gy/particle that is 7.26 times more than proton dose in healthy parts of liver. This ratio showed that tumor absorbs the maximum dose, while the healthy tissue absorbs the minimum dose. In the next step, the same procedure was done with mean source energy of 180 MeV for tumor in depth of 6 Cm. According to the results, the proton absorbed dose in tumor was 1.94 × 10-12 Gy/particle that is 9 times more than proton absorbed dose in healthy tissue. Also the maximum neutron equivalent absorbed dose in healthy tissue is of the order of 10-14 Sv that can be ignorable in comparison with proton treatment effects of proton therapy.http://ijpr.iut.ac.ir/article_1760_cffc27990266c2c6effd90b544f8b8a7.pdfproton therapyliver cancerdosimetry |
| spellingShingle | S Z Moayedian A Karimian MH Alamatsaz Absorbed dose assessment due to proton and neutron particles in tumoral and healthy tissues of liver in proton-therapy using Monte Carlo method Iranian Journal of Physics Research proton therapy liver cancer dosimetry |
| title | Absorbed dose assessment due to proton and neutron particles in tumoral and healthy tissues of liver in proton-therapy using Monte Carlo method |
| title_full | Absorbed dose assessment due to proton and neutron particles in tumoral and healthy tissues of liver in proton-therapy using Monte Carlo method |
| title_fullStr | Absorbed dose assessment due to proton and neutron particles in tumoral and healthy tissues of liver in proton-therapy using Monte Carlo method |
| title_full_unstemmed | Absorbed dose assessment due to proton and neutron particles in tumoral and healthy tissues of liver in proton-therapy using Monte Carlo method |
| title_short | Absorbed dose assessment due to proton and neutron particles in tumoral and healthy tissues of liver in proton-therapy using Monte Carlo method |
| title_sort | absorbed dose assessment due to proton and neutron particles in tumoral and healthy tissues of liver in proton therapy using monte carlo method |
| topic | proton therapy liver cancer dosimetry |
| url | http://ijpr.iut.ac.ir/article_1760_cffc27990266c2c6effd90b544f8b8a7.pdf |
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