Species Differences in the Nutrition of Retinal Ganglion Cells among Mammals Frequently Used as Animal Models
The diffusion rate for proper nutrition of the inner retina depends mainly on four factors which are discussed in this review: 1. The diffusion distance between blood and retinal ganglion cells shows morphological variants in different mammalian species, namely a choroidal nutrition type, a retinal...
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MDPI AG
2019-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/10/1254 |
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| author | Christian Albrecht May |
| author_facet | Christian Albrecht May |
| author_sort | Christian Albrecht May |
| collection | DOAJ |
| description | The diffusion rate for proper nutrition of the inner retina depends mainly on four factors which are discussed in this review: 1. The diffusion distance between blood and retinal ganglion cells shows morphological variants in different mammalian species, namely a choroidal nutrition type, a retinal nutrition type, and a mixture of both types. 2. Low oxygen concentration levels in the inner retina force the diffusion of oxygen especially in the choroidal nutrition type. Other nutrients might be supplied by surrounding cells, mainly Müller cells. 3. Diffusion in the eye is influenced by the intraocular pressure, which is vital for the retinal ganglion cells but might also influence their proper function. Again, the nutrition types established might explain the differences in normal intraocular pressure levels among different species. 4. Temperature is a critical feature in the eye which has to be buffered to avoid neuronal damage. The most effective buffer system is the increased blood turnover in the choroid which has to be established in all species. |
| first_indexed | 2024-03-12T06:57:07Z |
| format | Article |
| id | doaj.art-70aa9fdfa39a4bd794fac20b038b1e60 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:57:07Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
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| series | Cells |
| spelling | doaj.art-70aa9fdfa39a4bd794fac20b038b1e602023-09-02T23:59:09ZengMDPI AGCells2073-44092019-10-01810125410.3390/cells8101254cells8101254Species Differences in the Nutrition of Retinal Ganglion Cells among Mammals Frequently Used as Animal ModelsChristian Albrecht May0Department of Anatomy, Medizinische Fakultät Carl Gustav Carus, TU Dresden, 01307 Dresden, GermanyThe diffusion rate for proper nutrition of the inner retina depends mainly on four factors which are discussed in this review: 1. The diffusion distance between blood and retinal ganglion cells shows morphological variants in different mammalian species, namely a choroidal nutrition type, a retinal nutrition type, and a mixture of both types. 2. Low oxygen concentration levels in the inner retina force the diffusion of oxygen especially in the choroidal nutrition type. Other nutrients might be supplied by surrounding cells, mainly Müller cells. 3. Diffusion in the eye is influenced by the intraocular pressure, which is vital for the retinal ganglion cells but might also influence their proper function. Again, the nutrition types established might explain the differences in normal intraocular pressure levels among different species. 4. Temperature is a critical feature in the eye which has to be buffered to avoid neuronal damage. The most effective buffer system is the increased blood turnover in the choroid which has to be established in all species.https://www.mdpi.com/2073-4409/8/10/1254retinal ganglion cellvasculatureeyemorphologyfunction |
| spellingShingle | Christian Albrecht May Species Differences in the Nutrition of Retinal Ganglion Cells among Mammals Frequently Used as Animal Models Cells retinal ganglion cell vasculature eye morphology function |
| title | Species Differences in the Nutrition of Retinal Ganglion Cells among Mammals Frequently Used as Animal Models |
| title_full | Species Differences in the Nutrition of Retinal Ganglion Cells among Mammals Frequently Used as Animal Models |
| title_fullStr | Species Differences in the Nutrition of Retinal Ganglion Cells among Mammals Frequently Used as Animal Models |
| title_full_unstemmed | Species Differences in the Nutrition of Retinal Ganglion Cells among Mammals Frequently Used as Animal Models |
| title_short | Species Differences in the Nutrition of Retinal Ganglion Cells among Mammals Frequently Used as Animal Models |
| title_sort | species differences in the nutrition of retinal ganglion cells among mammals frequently used as animal models |
| topic | retinal ganglion cell vasculature eye morphology function |
| url | https://www.mdpi.com/2073-4409/8/10/1254 |
| work_keys_str_mv | AT christianalbrechtmay speciesdifferencesinthenutritionofretinalganglioncellsamongmammalsfrequentlyusedasanimalmodels |