Differences in the treatment needs of patients with dementia with Lewy bodies and their caregivers and differences in their physicians’ awareness of those treatment needs according to the clinical department visited by the patients: a subanalysis of an observational survey study
Abstract Background We investigated whether the treatment needs of patients with dementia with Lewy bodies (DLB) and their caregivers, along with their attending physicians’ perception of those treatment needs, differ according to the clinical department visited by the patients. Methods This was a s...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-03-01
|
| Series: | Alzheimer’s Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13195-024-01419-6 |
| _version_ | 1797259429364629504 |
|---|---|
| author | Manabu Ikeda Shunji Toya Yuta Manabe Hajime Yamakage Mamoru Hashimoto |
| author_facet | Manabu Ikeda Shunji Toya Yuta Manabe Hajime Yamakage Mamoru Hashimoto |
| author_sort | Manabu Ikeda |
| collection | DOAJ |
| description | Abstract Background We investigated whether the treatment needs of patients with dementia with Lewy bodies (DLB) and their caregivers, along with their attending physicians’ perception of those treatment needs, differ according to the clinical department visited by the patients. Methods This was a subanalysis of a multicenter, cross-sectional, observational survey study. Data from the main study were classified according to the clinical department visited by the patient: psychiatric group (P-group), geriatric internal medicine group (G-group), and neurology group (N-group). The treatment needs of patients and caregivers were defined as “the symptom that causes them the most distress”, and the frequency of each answer was tabulated. Results This subanalysis included 134, 65, and 49 patient–caregiver pairs in the P-, G-, and N-groups, respectively. Statistically significant differences in patient background characteristics such as patient age; initial symptom domains; use of cholinesterase inhibitors, levodopa, antipsychotics, and Yokukansan; and total scores of the Mini-Mental State Examination, Neuropsychiatric Inventory-12, and Movement Disorder Society-Unified Parkinson’s Disease Rating Scale Parts II and III were shown among the three subgroups. While there were no differences in patients’ treatment needs among the subgroups, residual analysis showed that in the N-group, parkinsonism was more of a problem than other symptom domains (p = 0.001). There were significant differences in caregivers’ treatment needs among the three subgroups (p < 0.001). The patient–physician concordance rates for the symptom domains that caused patients the most distress were: P-group, 42.9% (kappa coefficient [κ] = 0.264); G-group, 33.3% (κ = 0.135), and N-group, 67.6% (κ = 0.484). The caregiver–physician concordance rates for the symptom domains that caused the caregivers the most distress were: P-group, 54.8% (κ = 0.351), G-group, 50.0% (κ = 0.244), and N-group, 47.4% (κ = 0.170). Conclusion This subanalysis revealed differences in the treatment needs of patients with DLB and their caregivers according to the clinical department they attended. There might be a lack of awareness of those treatment needs by the attending physicians, regardless of their specialty. Trial registration UMIN Clinical Trials Registry UMIN000041844. |
| first_indexed | 2024-04-24T23:09:17Z |
| format | Article |
| id | doaj.art-70aac22dc3784ef684078afd3307a7d1 |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-04-24T23:09:17Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-70aac22dc3784ef684078afd3307a7d12024-03-17T12:17:47ZengBMCAlzheimer’s Research & Therapy1758-91932024-03-0116111210.1186/s13195-024-01419-6Differences in the treatment needs of patients with dementia with Lewy bodies and their caregivers and differences in their physicians’ awareness of those treatment needs according to the clinical department visited by the patients: a subanalysis of an observational survey studyManabu Ikeda0Shunji Toya1Yuta Manabe2Hajime Yamakage3Mamoru Hashimoto4Department of Psychiatry, Osaka University Graduate School of MedicineMedical Science, Sumitomo Pharma Co., Ltd.Department of Advanced Clinical Medicine, Division of Dementia and Geriatric Medicine, Kanagawa Dental University School of DentistryInsight Clinical Development Group, 3H Medi Solution Inc.Department of Psychiatry, Osaka University Graduate School of MedicineAbstract Background We investigated whether the treatment needs of patients with dementia with Lewy bodies (DLB) and their caregivers, along with their attending physicians’ perception of those treatment needs, differ according to the clinical department visited by the patients. Methods This was a subanalysis of a multicenter, cross-sectional, observational survey study. Data from the main study were classified according to the clinical department visited by the patient: psychiatric group (P-group), geriatric internal medicine group (G-group), and neurology group (N-group). The treatment needs of patients and caregivers were defined as “the symptom that causes them the most distress”, and the frequency of each answer was tabulated. Results This subanalysis included 134, 65, and 49 patient–caregiver pairs in the P-, G-, and N-groups, respectively. Statistically significant differences in patient background characteristics such as patient age; initial symptom domains; use of cholinesterase inhibitors, levodopa, antipsychotics, and Yokukansan; and total scores of the Mini-Mental State Examination, Neuropsychiatric Inventory-12, and Movement Disorder Society-Unified Parkinson’s Disease Rating Scale Parts II and III were shown among the three subgroups. While there were no differences in patients’ treatment needs among the subgroups, residual analysis showed that in the N-group, parkinsonism was more of a problem than other symptom domains (p = 0.001). There were significant differences in caregivers’ treatment needs among the three subgroups (p < 0.001). The patient–physician concordance rates for the symptom domains that caused patients the most distress were: P-group, 42.9% (kappa coefficient [κ] = 0.264); G-group, 33.3% (κ = 0.135), and N-group, 67.6% (κ = 0.484). The caregiver–physician concordance rates for the symptom domains that caused the caregivers the most distress were: P-group, 54.8% (κ = 0.351), G-group, 50.0% (κ = 0.244), and N-group, 47.4% (κ = 0.170). Conclusion This subanalysis revealed differences in the treatment needs of patients with DLB and their caregivers according to the clinical department they attended. There might be a lack of awareness of those treatment needs by the attending physicians, regardless of their specialty. Trial registration UMIN Clinical Trials Registry UMIN000041844.https://doi.org/10.1186/s13195-024-01419-6Attending physiciansCaregiversClinical departmentDementia with Lewy bodiesObservational studyPatients |
| spellingShingle | Manabu Ikeda Shunji Toya Yuta Manabe Hajime Yamakage Mamoru Hashimoto Differences in the treatment needs of patients with dementia with Lewy bodies and their caregivers and differences in their physicians’ awareness of those treatment needs according to the clinical department visited by the patients: a subanalysis of an observational survey study Alzheimer’s Research & Therapy Attending physicians Caregivers Clinical department Dementia with Lewy bodies Observational study Patients |
| title | Differences in the treatment needs of patients with dementia with Lewy bodies and their caregivers and differences in their physicians’ awareness of those treatment needs according to the clinical department visited by the patients: a subanalysis of an observational survey study |
| title_full | Differences in the treatment needs of patients with dementia with Lewy bodies and their caregivers and differences in their physicians’ awareness of those treatment needs according to the clinical department visited by the patients: a subanalysis of an observational survey study |
| title_fullStr | Differences in the treatment needs of patients with dementia with Lewy bodies and their caregivers and differences in their physicians’ awareness of those treatment needs according to the clinical department visited by the patients: a subanalysis of an observational survey study |
| title_full_unstemmed | Differences in the treatment needs of patients with dementia with Lewy bodies and their caregivers and differences in their physicians’ awareness of those treatment needs according to the clinical department visited by the patients: a subanalysis of an observational survey study |
| title_short | Differences in the treatment needs of patients with dementia with Lewy bodies and their caregivers and differences in their physicians’ awareness of those treatment needs according to the clinical department visited by the patients: a subanalysis of an observational survey study |
| title_sort | differences in the treatment needs of patients with dementia with lewy bodies and their caregivers and differences in their physicians awareness of those treatment needs according to the clinical department visited by the patients a subanalysis of an observational survey study |
| topic | Attending physicians Caregivers Clinical department Dementia with Lewy bodies Observational study Patients |
| url | https://doi.org/10.1186/s13195-024-01419-6 |
| work_keys_str_mv | AT manabuikeda differencesinthetreatmentneedsofpatientswithdementiawithlewybodiesandtheircaregiversanddifferencesintheirphysiciansawarenessofthosetreatmentneedsaccordingtotheclinicaldepartmentvisitedbythepatientsasubanalysisofanobservationalsurveystudy AT shunjitoya differencesinthetreatmentneedsofpatientswithdementiawithlewybodiesandtheircaregiversanddifferencesintheirphysiciansawarenessofthosetreatmentneedsaccordingtotheclinicaldepartmentvisitedbythepatientsasubanalysisofanobservationalsurveystudy AT yutamanabe differencesinthetreatmentneedsofpatientswithdementiawithlewybodiesandtheircaregiversanddifferencesintheirphysiciansawarenessofthosetreatmentneedsaccordingtotheclinicaldepartmentvisitedbythepatientsasubanalysisofanobservationalsurveystudy AT hajimeyamakage differencesinthetreatmentneedsofpatientswithdementiawithlewybodiesandtheircaregiversanddifferencesintheirphysiciansawarenessofthosetreatmentneedsaccordingtotheclinicaldepartmentvisitedbythepatientsasubanalysisofanobservationalsurveystudy AT mamoruhashimoto differencesinthetreatmentneedsofpatientswithdementiawithlewybodiesandtheircaregiversanddifferencesintheirphysiciansawarenessofthosetreatmentneedsaccordingtotheclinicaldepartmentvisitedbythepatientsasubanalysisofanobservationalsurveystudy |