Biomaterials Based on Chitosan and Polyvinyl Alcohol as a Drug Delivery System with Wound-Healing Effects
The excellent biological properties of chitosan (CS) together with the increased oxygen permeability of polyvinyl alcohol (PVA) were the prerequisites for the creation of a wound healing dressing that would also function as a system for L-arginine (L-arg) and caffeine (Caff) delivery. Using the free...
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MDPI AG
2023-02-01
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| Online Access: | https://www.mdpi.com/2310-2861/9/2/122 |
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| author | Simona Petronela Gherman Gabriela Biliuță Adrian Bele Alina Mirela Ipate Raluca Ioana Baron Lăcrămioara Ochiuz Adrian Florin Șpac Daniela Elena Zavastin |
| author_facet | Simona Petronela Gherman Gabriela Biliuță Adrian Bele Alina Mirela Ipate Raluca Ioana Baron Lăcrămioara Ochiuz Adrian Florin Șpac Daniela Elena Zavastin |
| author_sort | Simona Petronela Gherman |
| collection | DOAJ |
| description | The excellent biological properties of chitosan (CS) together with the increased oxygen permeability of polyvinyl alcohol (PVA) were the prerequisites for the creation of a wound healing dressing that would also function as a system for L-arginine (L-arg) and caffeine (Caff) delivery. Using the freezing/thawing method, 12 hydrogels were obtained in PVA:CS polymer ratios of 90:10, 75:25, and 60:40, and all were loaded with L-arg, Caff, and the mixture of L-arg and Caff, respectively. Afterwards, an inorganic material (zeolite–Z) was added to the best polymeric ratio (75:25) and loaded with active substances. The interactions between the constituents of the hydrogels were analyzed by FTIR spectroscopy, the uniformity of the network was highlighted by the SEM technique, and the dynamic water vapor sorption capacity was evaluated. In the presence of the inorganic material, the release profile of the active substances is delayed, and in vitro permeation kinetics proves that the equilibrium state is not reached even after four hours. The synergy of the constituents in the polymer network recommends that they be used in medical applications, such as wound healing dressings. |
| first_indexed | 2024-03-11T08:47:56Z |
| format | Article |
| id | doaj.art-70ac96be4f3c4dd3856002daaf6deec3 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-11T08:47:56Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-70ac96be4f3c4dd3856002daaf6deec32023-11-16T20:39:31ZengMDPI AGGels2310-28612023-02-019212210.3390/gels9020122Biomaterials Based on Chitosan and Polyvinyl Alcohol as a Drug Delivery System with Wound-Healing EffectsSimona Petronela Gherman0Gabriela Biliuță1Adrian Bele2Alina Mirela Ipate3Raluca Ioana Baron4Lăcrămioara Ochiuz5Adrian Florin Șpac6Daniela Elena Zavastin7Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 16th University Str., 700115 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry of Romanian Academy, 41 A, Grigore Ghica Voda Alley, 700487 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry of Romanian Academy, 41 A, Grigore Ghica Voda Alley, 700487 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry of Romanian Academy, 41 A, Grigore Ghica Voda Alley, 700487 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry of Romanian Academy, 41 A, Grigore Ghica Voda Alley, 700487 Iasi, RomaniaFaculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 16th University Str., 700115 Iasi, RomaniaFaculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 16th University Str., 700115 Iasi, RomaniaFaculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 16th University Str., 700115 Iasi, RomaniaThe excellent biological properties of chitosan (CS) together with the increased oxygen permeability of polyvinyl alcohol (PVA) were the prerequisites for the creation of a wound healing dressing that would also function as a system for L-arginine (L-arg) and caffeine (Caff) delivery. Using the freezing/thawing method, 12 hydrogels were obtained in PVA:CS polymer ratios of 90:10, 75:25, and 60:40, and all were loaded with L-arg, Caff, and the mixture of L-arg and Caff, respectively. Afterwards, an inorganic material (zeolite–Z) was added to the best polymeric ratio (75:25) and loaded with active substances. The interactions between the constituents of the hydrogels were analyzed by FTIR spectroscopy, the uniformity of the network was highlighted by the SEM technique, and the dynamic water vapor sorption capacity was evaluated. In the presence of the inorganic material, the release profile of the active substances is delayed, and in vitro permeation kinetics proves that the equilibrium state is not reached even after four hours. The synergy of the constituents in the polymer network recommends that they be used in medical applications, such as wound healing dressings.https://www.mdpi.com/2310-2861/9/2/122L-argininecaffeinewound healingentrapment efficiencysorption isothermdrug release |
| spellingShingle | Simona Petronela Gherman Gabriela Biliuță Adrian Bele Alina Mirela Ipate Raluca Ioana Baron Lăcrămioara Ochiuz Adrian Florin Șpac Daniela Elena Zavastin Biomaterials Based on Chitosan and Polyvinyl Alcohol as a Drug Delivery System with Wound-Healing Effects Gels L-arginine caffeine wound healing entrapment efficiency sorption isotherm drug release |
| title | Biomaterials Based on Chitosan and Polyvinyl Alcohol as a Drug Delivery System with Wound-Healing Effects |
| title_full | Biomaterials Based on Chitosan and Polyvinyl Alcohol as a Drug Delivery System with Wound-Healing Effects |
| title_fullStr | Biomaterials Based on Chitosan and Polyvinyl Alcohol as a Drug Delivery System with Wound-Healing Effects |
| title_full_unstemmed | Biomaterials Based on Chitosan and Polyvinyl Alcohol as a Drug Delivery System with Wound-Healing Effects |
| title_short | Biomaterials Based on Chitosan and Polyvinyl Alcohol as a Drug Delivery System with Wound-Healing Effects |
| title_sort | biomaterials based on chitosan and polyvinyl alcohol as a drug delivery system with wound healing effects |
| topic | L-arginine caffeine wound healing entrapment efficiency sorption isotherm drug release |
| url | https://www.mdpi.com/2310-2861/9/2/122 |
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