The Role of Apoptosis in the Pathology of Pancreatic Cancer
Pancreatic cancer is a disease with high resistance to most common therapies and therefore has a poor prognosis, which is partly due to a lack of reaction to apoptotic stimuli. Signal transduction of such stimuli includes a death receptor-mediated extrinsic pathway as well as an intrinsic pathway li...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2010-12-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/3/1/1/ |
| _version_ | 1797761983720718336 |
|---|---|
| author | Hans Detlev Saeger Christian Pilarsky Robert Grützmann Felix Rückert Kristin Werner Nicole Samm |
| author_facet | Hans Detlev Saeger Christian Pilarsky Robert Grützmann Felix Rückert Kristin Werner Nicole Samm |
| author_sort | Hans Detlev Saeger |
| collection | DOAJ |
| description | Pancreatic cancer is a disease with high resistance to most common therapies and therefore has a poor prognosis, which is partly due to a lack of reaction to apoptotic stimuli. Signal transduction of such stimuli includes a death receptor-mediated extrinsic pathway as well as an intrinsic pathway linked to the mitochondria. Defects in apoptotic pathways and the deregulation of apoptotic proteins, such as Survivin, Bcl-2, Bcl-xL and Mcl-1, play decisive roles in the development of pancreatic cancer. Investigation of the molecular mechanism allowing tumors to resist apoptotic cell death would lead to an improved understanding of the physiology and the development of new molecular strategies in pancreatic cancer. |
| first_indexed | 2024-03-12T19:21:54Z |
| format | Article |
| id | doaj.art-70ad511a4a7b41c5aca8cc5f3c445299 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:21:54Z |
| publishDate | 2010-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-70ad511a4a7b41c5aca8cc5f3c4452992023-08-02T05:07:11ZengMDPI AGCancers2072-66942010-12-013111610.3390/cancers3010001The Role of Apoptosis in the Pathology of Pancreatic CancerHans Detlev SaegerChristian PilarskyRobert GrützmannFelix RückertKristin WernerNicole SammPancreatic cancer is a disease with high resistance to most common therapies and therefore has a poor prognosis, which is partly due to a lack of reaction to apoptotic stimuli. Signal transduction of such stimuli includes a death receptor-mediated extrinsic pathway as well as an intrinsic pathway linked to the mitochondria. Defects in apoptotic pathways and the deregulation of apoptotic proteins, such as Survivin, Bcl-2, Bcl-xL and Mcl-1, play decisive roles in the development of pancreatic cancer. Investigation of the molecular mechanism allowing tumors to resist apoptotic cell death would lead to an improved understanding of the physiology and the development of new molecular strategies in pancreatic cancer.http://www.mdpi.com/2072-6694/3/1/1/apoptosissignal transduction pathwaypancreatic cancer |
| spellingShingle | Hans Detlev Saeger Christian Pilarsky Robert Grützmann Felix Rückert Kristin Werner Nicole Samm The Role of Apoptosis in the Pathology of Pancreatic Cancer Cancers apoptosis signal transduction pathway pancreatic cancer |
| title | The Role of Apoptosis in the Pathology of Pancreatic Cancer |
| title_full | The Role of Apoptosis in the Pathology of Pancreatic Cancer |
| title_fullStr | The Role of Apoptosis in the Pathology of Pancreatic Cancer |
| title_full_unstemmed | The Role of Apoptosis in the Pathology of Pancreatic Cancer |
| title_short | The Role of Apoptosis in the Pathology of Pancreatic Cancer |
| title_sort | role of apoptosis in the pathology of pancreatic cancer |
| topic | apoptosis signal transduction pathway pancreatic cancer |
| url | http://www.mdpi.com/2072-6694/3/1/1/ |
| work_keys_str_mv | AT hansdetlevsaeger theroleofapoptosisinthepathologyofpancreaticcancer AT christianpilarsky theroleofapoptosisinthepathologyofpancreaticcancer AT robertgrutzmann theroleofapoptosisinthepathologyofpancreaticcancer AT felixruckert theroleofapoptosisinthepathologyofpancreaticcancer AT kristinwerner theroleofapoptosisinthepathologyofpancreaticcancer AT nicolesamm theroleofapoptosisinthepathologyofpancreaticcancer AT hansdetlevsaeger roleofapoptosisinthepathologyofpancreaticcancer AT christianpilarsky roleofapoptosisinthepathologyofpancreaticcancer AT robertgrutzmann roleofapoptosisinthepathologyofpancreaticcancer AT felixruckert roleofapoptosisinthepathologyofpancreaticcancer AT kristinwerner roleofapoptosisinthepathologyofpancreaticcancer AT nicolesamm roleofapoptosisinthepathologyofpancreaticcancer |