Rapid development of metastatic pulmonary calcifications in primary hyperparathyroidism: a case report and literature review
Abstract Background Metastatic pulmonary calcification (MPC) is rarely reported in primary hyperparathyroidism, especially MPC develops quickly. We report such a case here with a literature review. Case presentation A 41-year-old woman presented with cough and dyspnea. Data from clinical, radiologic...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-05-01
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| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13000-017-0628-1 |
| _version_ | 1818035291796013056 |
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| author | Hui-ming Sun Fei Chen Hong-lin Yin Xiao-yong Xu Hong-bing Liu Bei-lei Zhao |
| author_facet | Hui-ming Sun Fei Chen Hong-lin Yin Xiao-yong Xu Hong-bing Liu Bei-lei Zhao |
| author_sort | Hui-ming Sun |
| collection | DOAJ |
| description | Abstract Background Metastatic pulmonary calcification (MPC) is rarely reported in primary hyperparathyroidism, especially MPC develops quickly. We report such a case here with a literature review. Case presentation A 41-year-old woman presented with cough and dyspnea. Data from clinical, radiological, pathological, technetium (99mTc)-methylene diphosphonate (MDP) bone scintillation imaging, and 99mTc-methoxy isobutyl isonitrile (MIBI) thyroid imaging were studied. 99mTc-MIBI thyroid imaging indicated hyperparathyroidism. Chest computed tomography (CT) scans showed rapidly progressive bilateral pulmonary multiple high-density shadows with mass consolidation and exudation in only five days. 99mTc-MDP bone scintillation imaging indicated bilateral pulmonary calcifications. CT-guided lung biopsy showed multifocal irregularities of calcium deposition and calcified bodies in the pulmonary interstitium. The patient showed gradually clinical and radiological improvement after surgical removal of the parathyroid adenoma. Conclusion Rapidly progressive MPC tends to be misdiagnosed as many primary pulmonary diseases. 99mTc-MDP bone scintillation imaging and pulmonary biopsy could be performed to differentiate metastatic pulmonary calcification from other diseases. Surgical resection of the parathyroid gland is helpful for treatment of MPC in patients with primary hyperparathyroidism and is regularly recommended. |
| first_indexed | 2024-12-10T06:52:44Z |
| format | Article |
| id | doaj.art-70ae7e561ede43a080b6c88e46e20935 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-10T06:52:44Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-70ae7e561ede43a080b6c88e46e209352022-12-22T01:58:31ZengBMCDiagnostic Pathology1746-15962017-05-011211610.1186/s13000-017-0628-1Rapid development of metastatic pulmonary calcifications in primary hyperparathyroidism: a case report and literature reviewHui-ming Sun0Fei Chen1Hong-lin Yin2Xiao-yong Xu3Hong-bing Liu4Bei-lei Zhao5Department of Respiratory and Critical Care Medicine, Jinling HospitalDepartment of Respiratory and Critical Care Medicine, Jinling HospitalDepartment of Pathology, Jinling HospitalDepartment of Respiratory and Critical Care Medicine, Jinling HospitalDepartment of Respiratory and Critical Care Medicine, Jinling HospitalDepartment of Respiratory and Critical Care Medicine, Jinling HospitalAbstract Background Metastatic pulmonary calcification (MPC) is rarely reported in primary hyperparathyroidism, especially MPC develops quickly. We report such a case here with a literature review. Case presentation A 41-year-old woman presented with cough and dyspnea. Data from clinical, radiological, pathological, technetium (99mTc)-methylene diphosphonate (MDP) bone scintillation imaging, and 99mTc-methoxy isobutyl isonitrile (MIBI) thyroid imaging were studied. 99mTc-MIBI thyroid imaging indicated hyperparathyroidism. Chest computed tomography (CT) scans showed rapidly progressive bilateral pulmonary multiple high-density shadows with mass consolidation and exudation in only five days. 99mTc-MDP bone scintillation imaging indicated bilateral pulmonary calcifications. CT-guided lung biopsy showed multifocal irregularities of calcium deposition and calcified bodies in the pulmonary interstitium. The patient showed gradually clinical and radiological improvement after surgical removal of the parathyroid adenoma. Conclusion Rapidly progressive MPC tends to be misdiagnosed as many primary pulmonary diseases. 99mTc-MDP bone scintillation imaging and pulmonary biopsy could be performed to differentiate metastatic pulmonary calcification from other diseases. Surgical resection of the parathyroid gland is helpful for treatment of MPC in patients with primary hyperparathyroidism and is regularly recommended.http://link.springer.com/article/10.1186/s13000-017-0628-1Metastatic pulmonary calcificationPrimary hyperparathyroidism99mTc-MIBI thyroid imaging99mTc-MDP bone scintillation imaging |
| spellingShingle | Hui-ming Sun Fei Chen Hong-lin Yin Xiao-yong Xu Hong-bing Liu Bei-lei Zhao Rapid development of metastatic pulmonary calcifications in primary hyperparathyroidism: a case report and literature review Diagnostic Pathology Metastatic pulmonary calcification Primary hyperparathyroidism 99mTc-MIBI thyroid imaging 99mTc-MDP bone scintillation imaging |
| title | Rapid development of metastatic pulmonary calcifications in primary hyperparathyroidism: a case report and literature review |
| title_full | Rapid development of metastatic pulmonary calcifications in primary hyperparathyroidism: a case report and literature review |
| title_fullStr | Rapid development of metastatic pulmonary calcifications in primary hyperparathyroidism: a case report and literature review |
| title_full_unstemmed | Rapid development of metastatic pulmonary calcifications in primary hyperparathyroidism: a case report and literature review |
| title_short | Rapid development of metastatic pulmonary calcifications in primary hyperparathyroidism: a case report and literature review |
| title_sort | rapid development of metastatic pulmonary calcifications in primary hyperparathyroidism a case report and literature review |
| topic | Metastatic pulmonary calcification Primary hyperparathyroidism 99mTc-MIBI thyroid imaging 99mTc-MDP bone scintillation imaging |
| url | http://link.springer.com/article/10.1186/s13000-017-0628-1 |
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