In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells

In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells

Abstract Background Acute Myeloid Leukemia (AML) is a malignancy of myeloid precursor cells that arise from genomic alterations in the expression of key growth regulatory genes causing cells to assume an undifferentiated state and continue to proliferate. Recent efforts have focused on developing th...

Full description

Bibliographic Details
Main Authors: Justin J. Montoya, Megan A. Turnidge, Daniel H. Wai, Apurvi R. Patel, David W. Lee, Vijay Gokhale, Laurence H. Hurley, Robert J. Arceci, Cynthia Wetmore, David O. Azorsa
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Cancer
Subjects:
MYC
G-quadruplex
AML
Bcl-2
Bcl-XL
Navitoclax
Online Access:https://doi.org/10.1186/s12885-019-6464-9

Similar Items

Similar Items