Clinical and Laboratory Findings of Nosocomial Sepsis in Extremely Low Birth Weight Infants According to Causative Organisms
Background: nosocomial sepsis remains a significant source of morbidity and mortality in extremely low birth weight (ELBW) infants. Early and accurate diagnosis is very important, but it is difficult due to the similarities in clinical manifestation between the causative microorganisms. We tried to...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/1/260 |
| _version_ | 1797498604778160128 |
|---|---|
| author | Kyung-Hee Park Su-Jung Park Mi-Hye Bae Seong-Hee Jeong Mun-Hui Jeong Narae Lee Young-Mi Han Shin-Yun Byun |
| author_facet | Kyung-Hee Park Su-Jung Park Mi-Hye Bae Seong-Hee Jeong Mun-Hui Jeong Narae Lee Young-Mi Han Shin-Yun Byun |
| author_sort | Kyung-Hee Park |
| collection | DOAJ |
| description | Background: nosocomial sepsis remains a significant source of morbidity and mortality in extremely low birth weight (ELBW) infants. Early and accurate diagnosis is very important, but it is difficult due to the similarities in clinical manifestation between the causative microorganisms. We tried to identify the differences between causative microorganisms in clinical and laboratory findings and to help choose antibiotics, when sepsis was suspected in ELBW infants. Methods: a retrospective study was conducted on preterm infants, born at less than 28 weeks of gestation, with a birth weight of less than 1000 g between January 2009 and December 2019. Clinical and laboratory findings of suspected sepsis, after the first 72 h of life, were assessed. We classified them into four groups according to blood culture results (gram positive, gram negative, fungal, and negative culture groups) and compared them. Results: a total of 158 patients were included after using the exclusion criteria, with 45 (29%) in the gram positive group, 35 (22%) in the gram negative group, 27 (17%) in the fungal group, and 51 (32%) in the negative culture group. There were no significant differences in mean gestational age, birth weight, and neonatal morbidities, except for the age of onset, which was earlier in the fungal group than other groups. White blood cell (WBC) counts were the highest in the gram negative group and the lowest in the fungal group. The mean platelet counts were the lowest in the fungal group. C-reactive protein (CRP) levels were the highest in the gram negative group, while glucose was the highest in the fungal group. Conclusions: in conclusion, we showed that there are some differences in laboratory findings, according to causative microorganisms in the nosocomial sepsis of ELBW infants. Increased WBC and CRP were associated with gram negative infection, while decreased platelet and glucose level were associated with fungal infection. These data may be helpful for choosing empirical antibiotics when sepsis is suspected. |
| first_indexed | 2024-03-10T03:35:43Z |
| format | Article |
| id | doaj.art-70b299a165a24b66a5a4789a272995a7 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:35:43Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-70b299a165a24b66a5a4789a272995a72023-11-23T11:46:11ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111126010.3390/jcm11010260Clinical and Laboratory Findings of Nosocomial Sepsis in Extremely Low Birth Weight Infants According to Causative OrganismsKyung-Hee Park0Su-Jung Park1Mi-Hye Bae2Seong-Hee Jeong3Mun-Hui Jeong4Narae Lee5Young-Mi Han6Shin-Yun Byun7Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine, Busan 49241, KoreaDepartment of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine, Busan 49241, KoreaDepartment of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine, Busan 49241, KoreaDepartment of Pediatrics, Pusan National University Children’s Hospital, Pusan National University School of Medicine, Yangsan 50612, KoreaDepartment of Pediatrics, Pusan National University Children’s Hospital, Pusan National University School of Medicine, Yangsan 50612, KoreaDepartment of Pediatrics, Pusan National University Children’s Hospital, Pusan National University School of Medicine, Yangsan 50612, KoreaDepartment of Pediatrics, Pusan National University Children’s Hospital, Pusan National University School of Medicine, Yangsan 50612, KoreaDepartment of Pediatrics, Pusan National University Children’s Hospital, Pusan National University School of Medicine, Yangsan 50612, KoreaBackground: nosocomial sepsis remains a significant source of morbidity and mortality in extremely low birth weight (ELBW) infants. Early and accurate diagnosis is very important, but it is difficult due to the similarities in clinical manifestation between the causative microorganisms. We tried to identify the differences between causative microorganisms in clinical and laboratory findings and to help choose antibiotics, when sepsis was suspected in ELBW infants. Methods: a retrospective study was conducted on preterm infants, born at less than 28 weeks of gestation, with a birth weight of less than 1000 g between January 2009 and December 2019. Clinical and laboratory findings of suspected sepsis, after the first 72 h of life, were assessed. We classified them into four groups according to blood culture results (gram positive, gram negative, fungal, and negative culture groups) and compared them. Results: a total of 158 patients were included after using the exclusion criteria, with 45 (29%) in the gram positive group, 35 (22%) in the gram negative group, 27 (17%) in the fungal group, and 51 (32%) in the negative culture group. There were no significant differences in mean gestational age, birth weight, and neonatal morbidities, except for the age of onset, which was earlier in the fungal group than other groups. White blood cell (WBC) counts were the highest in the gram negative group and the lowest in the fungal group. The mean platelet counts were the lowest in the fungal group. C-reactive protein (CRP) levels were the highest in the gram negative group, while glucose was the highest in the fungal group. Conclusions: in conclusion, we showed that there are some differences in laboratory findings, according to causative microorganisms in the nosocomial sepsis of ELBW infants. Increased WBC and CRP were associated with gram negative infection, while decreased platelet and glucose level were associated with fungal infection. These data may be helpful for choosing empirical antibiotics when sepsis is suspected.https://www.mdpi.com/2077-0383/11/1/260sepsispreterm infantextremely low birth weight |
| spellingShingle | Kyung-Hee Park Su-Jung Park Mi-Hye Bae Seong-Hee Jeong Mun-Hui Jeong Narae Lee Young-Mi Han Shin-Yun Byun Clinical and Laboratory Findings of Nosocomial Sepsis in Extremely Low Birth Weight Infants According to Causative Organisms Journal of Clinical Medicine sepsis preterm infant extremely low birth weight |
| title | Clinical and Laboratory Findings of Nosocomial Sepsis in Extremely Low Birth Weight Infants According to Causative Organisms |
| title_full | Clinical and Laboratory Findings of Nosocomial Sepsis in Extremely Low Birth Weight Infants According to Causative Organisms |
| title_fullStr | Clinical and Laboratory Findings of Nosocomial Sepsis in Extremely Low Birth Weight Infants According to Causative Organisms |
| title_full_unstemmed | Clinical and Laboratory Findings of Nosocomial Sepsis in Extremely Low Birth Weight Infants According to Causative Organisms |
| title_short | Clinical and Laboratory Findings of Nosocomial Sepsis in Extremely Low Birth Weight Infants According to Causative Organisms |
| title_sort | clinical and laboratory findings of nosocomial sepsis in extremely low birth weight infants according to causative organisms |
| topic | sepsis preterm infant extremely low birth weight |
| url | https://www.mdpi.com/2077-0383/11/1/260 |
| work_keys_str_mv | AT kyungheepark clinicalandlaboratoryfindingsofnosocomialsepsisinextremelylowbirthweightinfantsaccordingtocausativeorganisms AT sujungpark clinicalandlaboratoryfindingsofnosocomialsepsisinextremelylowbirthweightinfantsaccordingtocausativeorganisms AT mihyebae clinicalandlaboratoryfindingsofnosocomialsepsisinextremelylowbirthweightinfantsaccordingtocausativeorganisms AT seongheejeong clinicalandlaboratoryfindingsofnosocomialsepsisinextremelylowbirthweightinfantsaccordingtocausativeorganisms AT munhuijeong clinicalandlaboratoryfindingsofnosocomialsepsisinextremelylowbirthweightinfantsaccordingtocausativeorganisms AT naraelee clinicalandlaboratoryfindingsofnosocomialsepsisinextremelylowbirthweightinfantsaccordingtocausativeorganisms AT youngmihan clinicalandlaboratoryfindingsofnosocomialsepsisinextremelylowbirthweightinfantsaccordingtocausativeorganisms AT shinyunbyun clinicalandlaboratoryfindingsofnosocomialsepsisinextremelylowbirthweightinfantsaccordingtocausativeorganisms |