Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases
Abstract Background This study aimed to assess the baseline characteristics and clinical outcomes of coronavirus disease 2019 (COVID-19) in pediatric patients with rheumatic and musculoskeletal diseases (RMD) and identify the risk factors associated with symptomatic or severe disease defined as hosp...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | Pediatric Rheumatology Online Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12969-021-00648-5 |
| _version_ | 1818684486339002368 |
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| author | Daniel Clemente Clara Udaondo Jaime de Inocencio Juan Carlos Nieto Pilar Galán del Río Antía García Fernández Jaime Arroyo Palomo Javier Bachiller-Corral Juan Carlos Lopez Robledillo Claudia Millán Longo Leticia Leon Lydia Abasolo Alina Boteanu |
| author_facet | Daniel Clemente Clara Udaondo Jaime de Inocencio Juan Carlos Nieto Pilar Galán del Río Antía García Fernández Jaime Arroyo Palomo Javier Bachiller-Corral Juan Carlos Lopez Robledillo Claudia Millán Longo Leticia Leon Lydia Abasolo Alina Boteanu |
| author_sort | Daniel Clemente |
| collection | DOAJ |
| description | Abstract Background This study aimed to assess the baseline characteristics and clinical outcomes of coronavirus disease 2019 (COVID-19) in pediatric patients with rheumatic and musculoskeletal diseases (RMD) and identify the risk factors associated with symptomatic or severe disease defined as hospital admission, intensive care admission or death. Methods An observational longitudinal study was conducted during the first year of the SARS-CoV-2 pandemic (March 2020–March 2021). All pediatric patients attended at the rheumatology outpatient clinics of six tertiary referral hospitals in Madrid, Spain, with a diagnosis of RMD and COVID-19 were included. Main outcomes were symptomatic disease and hospital admission. The covariates were sociodemographic and clinical characteristics and treatment regimens. We ran a multivariable logistic regression model to assess associated factors for outcomes. Results The study population included 77 pediatric patients. Mean age was 11.88 (4.04) years Of these, 30 patients (38.96%) were asymptomatic, 41 (53.25%) had a mild-moderate COVID-19 and 6 patients (7.79%) required hospital admission. The median length of hospital admission was 5 (2–20) days, one patient required intensive care and there were no deaths. Previous comorbidities increased the risk for symptomatic disease and hospital admission. Compared with outpatients, the factor independently associated with hospital admission was previous use of glucocorticoids (OR 3.51; p = 0.00). No statistically significant risk factors for symptomatic COVID-19 were found in the final model. Conclusion No differences in COVID-19 outcomes according to childhood-onset rheumatic disease types were found. Results suggest that associated comorbidities and treatment with glucocorticoids increase the risk of hospital admission. |
| first_indexed | 2024-12-17T10:51:24Z |
| format | Article |
| id | doaj.art-70b401e0b5e542f78a24b6dd938052b3 |
| institution | Directory Open Access Journal |
| issn | 1546-0096 |
| language | English |
| last_indexed | 2024-12-17T10:51:24Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Pediatric Rheumatology Online Journal |
| spelling | doaj.art-70b401e0b5e542f78a24b6dd938052b32022-12-21T21:51:57ZengBMCPediatric Rheumatology Online Journal1546-00962021-11-011911810.1186/s12969-021-00648-5Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseasesDaniel Clemente0Clara Udaondo1Jaime de Inocencio2Juan Carlos Nieto3Pilar Galán del Río4Antía García Fernández5Jaime Arroyo Palomo6Javier Bachiller-Corral7Juan Carlos Lopez Robledillo8Claudia Millán Longo9Leticia Leon10Lydia Abasolo11Alina Boteanu12Pediatric Rheumatology Unit, Hospital Infantil Universitario Niño JesúsPediatric Rheumatology Department, Hospital Universitario La PazPediatric Rheumatology Department, Hospital Universitario 12 de OctubreRheumatology Department, Hospital Universitario Gregorio MarañonRheumatology Department, Hospital Universitario de FuenlabradaRheumatology Department, Hospital Universitario Ramón y CajalRheumatology Department, Hospital Universitario Ramón y CajalRheumatology Department, Hospital Universitario Ramón y CajalPediatric Rheumatology Unit, Hospital Infantil Universitario Niño JesúsPediatric Rheumatology Department, Hospital Universitario La PazRheumatology Department and IDISSC, Hospital Universitario Clinico San CarlosRheumatology Department and IDISSC, Hospital Universitario Clinico San CarlosRheumatology Department, Hospital Universitario Ramón y CajalAbstract Background This study aimed to assess the baseline characteristics and clinical outcomes of coronavirus disease 2019 (COVID-19) in pediatric patients with rheumatic and musculoskeletal diseases (RMD) and identify the risk factors associated with symptomatic or severe disease defined as hospital admission, intensive care admission or death. Methods An observational longitudinal study was conducted during the first year of the SARS-CoV-2 pandemic (March 2020–March 2021). All pediatric patients attended at the rheumatology outpatient clinics of six tertiary referral hospitals in Madrid, Spain, with a diagnosis of RMD and COVID-19 were included. Main outcomes were symptomatic disease and hospital admission. The covariates were sociodemographic and clinical characteristics and treatment regimens. We ran a multivariable logistic regression model to assess associated factors for outcomes. Results The study population included 77 pediatric patients. Mean age was 11.88 (4.04) years Of these, 30 patients (38.96%) were asymptomatic, 41 (53.25%) had a mild-moderate COVID-19 and 6 patients (7.79%) required hospital admission. The median length of hospital admission was 5 (2–20) days, one patient required intensive care and there were no deaths. Previous comorbidities increased the risk for symptomatic disease and hospital admission. Compared with outpatients, the factor independently associated with hospital admission was previous use of glucocorticoids (OR 3.51; p = 0.00). No statistically significant risk factors for symptomatic COVID-19 were found in the final model. Conclusion No differences in COVID-19 outcomes according to childhood-onset rheumatic disease types were found. Results suggest that associated comorbidities and treatment with glucocorticoids increase the risk of hospital admission.https://doi.org/10.1186/s12969-021-00648-5Childhood-onset rheumatic diseasesCOVID-19Chronic inflammatory arthritisAutoinflammatory diseasesMultisystemic autoimmune disorders |
| spellingShingle | Daniel Clemente Clara Udaondo Jaime de Inocencio Juan Carlos Nieto Pilar Galán del Río Antía García Fernández Jaime Arroyo Palomo Javier Bachiller-Corral Juan Carlos Lopez Robledillo Claudia Millán Longo Leticia Leon Lydia Abasolo Alina Boteanu Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases Pediatric Rheumatology Online Journal Childhood-onset rheumatic diseases COVID-19 Chronic inflammatory arthritis Autoinflammatory diseases Multisystemic autoimmune disorders |
| title | Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases |
| title_full | Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases |
| title_fullStr | Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases |
| title_full_unstemmed | Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases |
| title_short | Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases |
| title_sort | clinical characteristics and covid 19 outcomes in a regional cohort of pediatric patients with rheumatic diseases |
| topic | Childhood-onset rheumatic diseases COVID-19 Chronic inflammatory arthritis Autoinflammatory diseases Multisystemic autoimmune disorders |
| url | https://doi.org/10.1186/s12969-021-00648-5 |
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