Pocket Modification of ω-Amine Transaminase AtATA for Overcoming the Trade-Off Between Activity and Stability Toward 1-Acetonaphthone

Pocket Modification of ω-Amine Transaminase AtATA for Overcoming the Trade-Off Between Activity and Stability Toward 1-Acetonaphthone

Amine transaminases (ATAs) catalyze the asymmetric amination of prochiral ketones or aldehydes to their corresponding chiral amines. However, the trade-off between activity and stability in enzyme engineering represents a major obstacle to the practical application of ATAs. Overcoming this trade-off...

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Bibliographic Details
Main Authors: Jiaren Cao, Fangfang Fan, Changjiang Lyu, Sheng Hu, Weirui Zhao, Jiaqi Mei, Shuai Qiu, Lehe Mei, Jun Huang
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Engineering
Subjects:
Trade-off
Co-evolution
Amine transaminase
(R)-(+)-1(1-naphthyl)ethylamine
Online Access:http://www.sciencedirect.com/science/article/pii/S2095809923002023

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