The Effects of a Western Diet vs. a High-Fiber Unprocessed Diet on Health Outcomes in Mice Offspring
Diet influences critical periods of growth, including gestation and early development. We hypothesized that a maternal/early life diet reflecting unprocessed dietary components would positively affect offspring metabolic and anthropometric parameters. Using 9 C57BL-6 dams, we simulated exposure to a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/13/2858 |
| _version_ | 1797591060303577088 |
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| author | Elizabeth Herzl Emily E. Schmitt Grace Shearrer Jill F. Keith |
| author_facet | Elizabeth Herzl Emily E. Schmitt Grace Shearrer Jill F. Keith |
| author_sort | Elizabeth Herzl |
| collection | DOAJ |
| description | Diet influences critical periods of growth, including gestation and early development. We hypothesized that a maternal/early life diet reflecting unprocessed dietary components would positively affect offspring metabolic and anthropometric parameters. Using 9 C57BL-6 dams, we simulated exposure to a Western diet, a high-fiber unprocessed diet (HFUD), or a control diet. The dams consumed their respective diets (Western [<i>n</i> = 3], HFUD [<i>n</i> = 3], and control [<i>n</i> = 3]) through 3 weeks of pregnancy and 3 weeks of weaning; their offspring consumed the diet of their mother for 4.5 weeks post weaning. Measurements included dual X-ray absorptiometry (DEXA) scans, feed consumption, body weight, blood glucose, and insulin and glycated hemoglobin (HbA1c) in the offspring. Statistical analyses included one-way ANOVA with Tukey’s post hoc analysis. The offspring DEXA measures at 5 and 7.5 weeks post parturition revealed higher lean body mass development in the HFUD and control diet offspring compared to the Western diet offspring. An analysis indicated that blood glucose (<i>p</i> = 0.001) and HbA1c concentrations (<i>p</i> = 0.002) were lower among the HFUD offspring compared to the Western and control offspring. The results demonstrate that diet during gestation and early life consistent with traditional diet patterns may influence hyperglycemia and adiposity in offspring. |
| first_indexed | 2024-03-11T01:32:18Z |
| format | Article |
| id | doaj.art-70bb0f36cf00413ea5c137654d8e5c5d |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T01:32:18Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-70bb0f36cf00413ea5c137654d8e5c5d2023-11-18T17:13:28ZengMDPI AGNutrients2072-66432023-06-011513285810.3390/nu15132858The Effects of a Western Diet vs. a High-Fiber Unprocessed Diet on Health Outcomes in Mice OffspringElizabeth Herzl0Emily E. Schmitt1Grace Shearrer2Jill F. Keith3Department of Family & Consumer Sciences, University of Wyoming, Laramie, WY 82071, USADivision of Kinesiology & Health, University of Wyoming, Laramie, WY 82071, USADepartment of Family & Consumer Sciences, University of Wyoming, Laramie, WY 82071, USADepartment of Family & Consumer Sciences, University of Wyoming, Laramie, WY 82071, USADiet influences critical periods of growth, including gestation and early development. We hypothesized that a maternal/early life diet reflecting unprocessed dietary components would positively affect offspring metabolic and anthropometric parameters. Using 9 C57BL-6 dams, we simulated exposure to a Western diet, a high-fiber unprocessed diet (HFUD), or a control diet. The dams consumed their respective diets (Western [<i>n</i> = 3], HFUD [<i>n</i> = 3], and control [<i>n</i> = 3]) through 3 weeks of pregnancy and 3 weeks of weaning; their offspring consumed the diet of their mother for 4.5 weeks post weaning. Measurements included dual X-ray absorptiometry (DEXA) scans, feed consumption, body weight, blood glucose, and insulin and glycated hemoglobin (HbA1c) in the offspring. Statistical analyses included one-way ANOVA with Tukey’s post hoc analysis. The offspring DEXA measures at 5 and 7.5 weeks post parturition revealed higher lean body mass development in the HFUD and control diet offspring compared to the Western diet offspring. An analysis indicated that blood glucose (<i>p</i> = 0.001) and HbA1c concentrations (<i>p</i> = 0.002) were lower among the HFUD offspring compared to the Western and control offspring. The results demonstrate that diet during gestation and early life consistent with traditional diet patterns may influence hyperglycemia and adiposity in offspring.https://www.mdpi.com/2072-6643/15/13/2858fiberWestern dietunprocessedmaternal diet |
| spellingShingle | Elizabeth Herzl Emily E. Schmitt Grace Shearrer Jill F. Keith The Effects of a Western Diet vs. a High-Fiber Unprocessed Diet on Health Outcomes in Mice Offspring Nutrients fiber Western diet unprocessed maternal diet |
| title | The Effects of a Western Diet vs. a High-Fiber Unprocessed Diet on Health Outcomes in Mice Offspring |
| title_full | The Effects of a Western Diet vs. a High-Fiber Unprocessed Diet on Health Outcomes in Mice Offspring |
| title_fullStr | The Effects of a Western Diet vs. a High-Fiber Unprocessed Diet on Health Outcomes in Mice Offspring |
| title_full_unstemmed | The Effects of a Western Diet vs. a High-Fiber Unprocessed Diet on Health Outcomes in Mice Offspring |
| title_short | The Effects of a Western Diet vs. a High-Fiber Unprocessed Diet on Health Outcomes in Mice Offspring |
| title_sort | effects of a western diet vs a high fiber unprocessed diet on health outcomes in mice offspring |
| topic | fiber Western diet unprocessed maternal diet |
| url | https://www.mdpi.com/2072-6643/15/13/2858 |
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