The Zebrafish Cardiac Endothelial Cell—Roles in Development and Regeneration
In zebrafish, the spatiotemporal development of the vascular system is well described due to its stereotypical nature. However, the cellular and molecular mechanisms orchestrating post-embryonic vascular development, the maintenance of vascular homeostasis, or how coronary vessels integrate into the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/8/5/49 |
| _version_ | 1827693488762781696 |
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| author | Vanessa Lowe Laura Wisniewski Caroline Pellet-Many |
| author_facet | Vanessa Lowe Laura Wisniewski Caroline Pellet-Many |
| author_sort | Vanessa Lowe |
| collection | DOAJ |
| description | In zebrafish, the spatiotemporal development of the vascular system is well described due to its stereotypical nature. However, the cellular and molecular mechanisms orchestrating post-embryonic vascular development, the maintenance of vascular homeostasis, or how coronary vessels integrate into the growing heart are less well studied. In the context of cardiac regeneration, the central cellular mechanism by which the heart regenerates a fully functional myocardium relies on the proliferation of pre-existing cardiomyocytes; the epicardium and the endocardium are also known to play key roles in the regenerative process. Remarkably, revascularisation of the injured tissue occurs within a few hours after cardiac damage, thus generating a vascular network acting as a scaffold for the regenerating myocardium. The activation of the endocardium leads to the secretion of cytokines, further supporting the proliferation of the cardiomyocytes. Although epicardium, endocardium, and myocardium interact with each other to orchestrate heart development and regeneration, in this review, we focus on recent advances in the understanding of the development of the endocardium and the coronary vasculature in zebrafish as well as their pivotal roles in the heart regeneration process. |
| first_indexed | 2024-03-10T11:45:17Z |
| format | Article |
| id | doaj.art-70bd146999bc4985b914c99b8ab2e8b7 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T11:45:17Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-70bd146999bc4985b914c99b8ab2e8b72023-11-21T18:08:50ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252021-05-01854910.3390/jcdd8050049The Zebrafish Cardiac Endothelial Cell—Roles in Development and RegenerationVanessa Lowe0Laura Wisniewski1Caroline Pellet-Many2Heart Centre, Barts & The London School of Medicine, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UKCentre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University London, Charterhouse Square, London EC1M 6BQ, UKDepartment of Comparative Biomedical Sciences, Royal Veterinary College, 4 Royal College Street, London NW1 0TU, UKIn zebrafish, the spatiotemporal development of the vascular system is well described due to its stereotypical nature. However, the cellular and molecular mechanisms orchestrating post-embryonic vascular development, the maintenance of vascular homeostasis, or how coronary vessels integrate into the growing heart are less well studied. In the context of cardiac regeneration, the central cellular mechanism by which the heart regenerates a fully functional myocardium relies on the proliferation of pre-existing cardiomyocytes; the epicardium and the endocardium are also known to play key roles in the regenerative process. Remarkably, revascularisation of the injured tissue occurs within a few hours after cardiac damage, thus generating a vascular network acting as a scaffold for the regenerating myocardium. The activation of the endocardium leads to the secretion of cytokines, further supporting the proliferation of the cardiomyocytes. Although epicardium, endocardium, and myocardium interact with each other to orchestrate heart development and regeneration, in this review, we focus on recent advances in the understanding of the development of the endocardium and the coronary vasculature in zebrafish as well as their pivotal roles in the heart regeneration process.https://www.mdpi.com/2308-3425/8/5/49zebrafishheartregenerationdevelopmentcoronary vesselsendocardium |
| spellingShingle | Vanessa Lowe Laura Wisniewski Caroline Pellet-Many The Zebrafish Cardiac Endothelial Cell—Roles in Development and Regeneration Journal of Cardiovascular Development and Disease zebrafish heart regeneration development coronary vessels endocardium |
| title | The Zebrafish Cardiac Endothelial Cell—Roles in Development and Regeneration |
| title_full | The Zebrafish Cardiac Endothelial Cell—Roles in Development and Regeneration |
| title_fullStr | The Zebrafish Cardiac Endothelial Cell—Roles in Development and Regeneration |
| title_full_unstemmed | The Zebrafish Cardiac Endothelial Cell—Roles in Development and Regeneration |
| title_short | The Zebrafish Cardiac Endothelial Cell—Roles in Development and Regeneration |
| title_sort | zebrafish cardiac endothelial cell roles in development and regeneration |
| topic | zebrafish heart regeneration development coronary vessels endocardium |
| url | https://www.mdpi.com/2308-3425/8/5/49 |
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