CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES
Our understanding of anticancer immune surveillance currently serves as a basis for development of novel therapies that utilize patient’s own immune system as an anticancer agent. Previously, cancer immunotherapy mostly included non-specific immunomodulating agents, cytokines, or cancer cell-based t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2018-06-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/1535 |
| _version_ | 1797197950645960704 |
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| author | Yu. N. Lezhnin A. Yu. Khristichenko N. M. Ratnikova Yu. E. Kravchenko S. P. Chumakov |
| author_facet | Yu. N. Lezhnin A. Yu. Khristichenko N. M. Ratnikova Yu. E. Kravchenko S. P. Chumakov |
| author_sort | Yu. N. Lezhnin |
| collection | DOAJ |
| description | Our understanding of anticancer immune surveillance currently serves as a basis for development of novel therapies that utilize patient’s own immune system as an anticancer agent. Previously, cancer immunotherapy mostly included non-specific immunomodulating agents, cytokines, or cancer cell-based tumor vaccines. Emerging understanding of diverse interactions between the immune system and cancer cells allows to develop novel, more effective therapeutic approaches that target only specific populations of immune cells. Recent studies focus on testing efficiency of allogenic and authologous anticancer immunity, strategies for ex vivo expansion of these cells, and approaches to increase their anticancer activity and specificity. Most recent approaches focus on re-targeting immune cells to specific tumor antigens, shifting the balance of immunosuppressive tumor microenvironment towards immune stimulation and utilizing immune cells to target tumor architecture. This review is focused on the prospects of different immuno-therapeutic strategies. |
| first_indexed | 2024-03-08T05:48:47Z |
| format | Article |
| id | doaj.art-70bf3e70f41f401cb4a13e41f51b4853 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:52:07Z |
| publishDate | 2018-06-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-70bf3e70f41f401cb4a13e41f51b48532024-04-22T13:07:42ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2018-06-0120331334010.15789/1563-0625-2018-3-313-3401012CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASESYu. N. Lezhnin0A. Yu. Khristichenko1N. M. Ratnikova2Yu. E. Kravchenko3S. P. Chumakov4Shemyakin–Ovchinnikov Institute of Bioorganic ChemistryShemyakin–Ovchinnikov Institute of Bioorganic ChemistryShemyakin–Ovchinnikov Institute of Bioorganic ChemistryShemyakin–Ovchinnikov Institute of Bioorganic ChemistryShemyakin–Ovchinnikov Institute of Bioorganic ChemistryOur understanding of anticancer immune surveillance currently serves as a basis for development of novel therapies that utilize patient’s own immune system as an anticancer agent. Previously, cancer immunotherapy mostly included non-specific immunomodulating agents, cytokines, or cancer cell-based tumor vaccines. Emerging understanding of diverse interactions between the immune system and cancer cells allows to develop novel, more effective therapeutic approaches that target only specific populations of immune cells. Recent studies focus on testing efficiency of allogenic and authologous anticancer immunity, strategies for ex vivo expansion of these cells, and approaches to increase their anticancer activity and specificity. Most recent approaches focus on re-targeting immune cells to specific tumor antigens, shifting the balance of immunosuppressive tumor microenvironment towards immune stimulation and utilizing immune cells to target tumor architecture. This review is focused on the prospects of different immuno-therapeutic strategies.https://www.mimmun.ru/mimmun/article/view/1535сellular immunotherapytherapeutic antibodiesadoptive immunotherapycancer vaccinechimeric antigen receptor |
| spellingShingle | Yu. N. Lezhnin A. Yu. Khristichenko N. M. Ratnikova Yu. E. Kravchenko S. P. Chumakov CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES Медицинская иммунология сellular immunotherapy therapeutic antibodies adoptive immunotherapy cancer vaccine chimeric antigen receptor |
| title | CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES |
| title_full | CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES |
| title_fullStr | CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES |
| title_full_unstemmed | CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES |
| title_short | CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES |
| title_sort | cellular immunotherapy a modern approach to treatment of oncological diseases |
| topic | сellular immunotherapy therapeutic antibodies adoptive immunotherapy cancer vaccine chimeric antigen receptor |
| url | https://www.mimmun.ru/mimmun/article/view/1535 |
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