Increase in C-reactive protein as early predictor of anastomotic leakage in abdominal surgery
Objectives: The aim of this study was to evaluate the role of the C-reactive protein (CRP) and white cell count (WC) in the prediction of anastomotic leakage (AL) in major abdominal surgery. Methods: Multicenter, prospective, and observational study of adult patients who underwent major abdominal su...
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| Format: | Article |
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Permanyer
2022-01-01
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| Series: | Cirugía y Cirujanos |
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| Online Access: | https://www.cirugiaycirujanos.com/frame_esp.php?id=758 |
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| author | Bernardo Borraez-Segura Juan P. Orozco-Hernández Felipe Anduquia-Garay Natalia Hurtado-Hurtado Jessica Soto-Vásquez Iván D. Lozada-Martínez |
| author_facet | Bernardo Borraez-Segura Juan P. Orozco-Hernández Felipe Anduquia-Garay Natalia Hurtado-Hurtado Jessica Soto-Vásquez Iván D. Lozada-Martínez |
| author_sort | Bernardo Borraez-Segura |
| collection | DOAJ |
| description | Objectives: The aim of this study was to evaluate the role of the C-reactive protein (CRP) and white cell count (WC) in the prediction of anastomotic leakage (AL) in major abdominal surgery. Methods: Multicenter, prospective, and observational study of adult patients who underwent major abdominal surgery. CRP and hemogram were measured after post-operative day (POD) 3 and POD 5. Complications were classified according to the Clavien-Dindo classification. Diagnostic accuracy was evaluated by the area under the receiver operating characteristic curve (AUC). Results: A total of 97 patients were included in the study. The mean age was 63 ± 12 years and 47 (48%) were male. Colorectal (56%) and gastric cancer (36%) were the most frequent diagnoses. About 23% had post-operative complications, of which 5% had AL. The most significant predictive factor was the increase in CRP ≥ 2.84 mg/L among POD 3 and 5 (AUC, 0.99, sensitivity, 95.6%, specificity, 100%, positive likelihood ratio, 23.0). The accuracy of the other biomarkers was lower, CRP on POD 3 (AUC, 0.55), on POD 5 (AUC, 0.93), WC on POD 3 (AUC, 0.33), and POD 5 (AUC, 0.35). Conclusion: The increase of CRP among POD 3 and 5 was an early predictor of AL in adult patients with major abdominal surgery.
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| first_indexed | 2024-04-11T07:41:47Z |
| format | Article |
| id | doaj.art-70c4ccb0637b48768c834ae4e64e88b7 |
| institution | Directory Open Access Journal |
| issn | 2444-054X |
| language | English |
| last_indexed | 2024-04-11T07:41:47Z |
| publishDate | 2022-01-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Cirugía y Cirujanos |
| spelling | doaj.art-70c4ccb0637b48768c834ae4e64e88b72022-12-22T04:36:30ZengPermanyerCirugía y Cirujanos2444-054X2022-01-0190610.24875/CIRU.21000597Increase in C-reactive protein as early predictor of anastomotic leakage in abdominal surgeryBernardo Borraez-Segura0Juan P. Orozco-Hernández1Felipe Anduquia-Garay2Natalia Hurtado-Hurtado3Jessica Soto-Vásquez4Iván D. Lozada-Martínez5Department of Clinical Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, ColombiaDepartment of Clinical Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda; Grupo de Investigación Salud Comfamiliar, Clínica Comfamiliar, Pereira, Risaralda; ColombiaDepartment of Clinical Sciences, Universidad Tecnológica de Pereira, Pereira,; Future Surgeons Chapter, Colombian Surgery Association, Bogotá; ColombiaDepartment of Clinical Sciences, Universidad Tecnológica de Pereira, Pereira,; Future Surgeons Chapter, Colombian Surgery Association, Bogotá; ColombiaDepartment of Clinical Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, ColombiaFuture Surgeons Chapter, Colombian Surgery Association, Bogotá; Medical and Surgical Research Center, Cartagena. ColombiaObjectives: The aim of this study was to evaluate the role of the C-reactive protein (CRP) and white cell count (WC) in the prediction of anastomotic leakage (AL) in major abdominal surgery. Methods: Multicenter, prospective, and observational study of adult patients who underwent major abdominal surgery. CRP and hemogram were measured after post-operative day (POD) 3 and POD 5. Complications were classified according to the Clavien-Dindo classification. Diagnostic accuracy was evaluated by the area under the receiver operating characteristic curve (AUC). Results: A total of 97 patients were included in the study. The mean age was 63 ± 12 years and 47 (48%) were male. Colorectal (56%) and gastric cancer (36%) were the most frequent diagnoses. About 23% had post-operative complications, of which 5% had AL. The most significant predictive factor was the increase in CRP ≥ 2.84 mg/L among POD 3 and 5 (AUC, 0.99, sensitivity, 95.6%, specificity, 100%, positive likelihood ratio, 23.0). The accuracy of the other biomarkers was lower, CRP on POD 3 (AUC, 0.55), on POD 5 (AUC, 0.93), WC on POD 3 (AUC, 0.33), and POD 5 (AUC, 0.35). Conclusion: The increase of CRP among POD 3 and 5 was an early predictor of AL in adult patients with major abdominal surgery. https://www.cirugiaycirujanos.com/frame_esp.php?id=758C-reactive protein. Predictive value of tests. Anastomotic leak. Digestive system surgical procedures. |
| spellingShingle | Bernardo Borraez-Segura Juan P. Orozco-Hernández Felipe Anduquia-Garay Natalia Hurtado-Hurtado Jessica Soto-Vásquez Iván D. Lozada-Martínez Increase in C-reactive protein as early predictor of anastomotic leakage in abdominal surgery Cirugía y Cirujanos C-reactive protein. Predictive value of tests. Anastomotic leak. Digestive system surgical procedures. |
| title | Increase in C-reactive protein as early predictor of anastomotic leakage in abdominal surgery |
| title_full | Increase in C-reactive protein as early predictor of anastomotic leakage in abdominal surgery |
| title_fullStr | Increase in C-reactive protein as early predictor of anastomotic leakage in abdominal surgery |
| title_full_unstemmed | Increase in C-reactive protein as early predictor of anastomotic leakage in abdominal surgery |
| title_short | Increase in C-reactive protein as early predictor of anastomotic leakage in abdominal surgery |
| title_sort | increase in c reactive protein as early predictor of anastomotic leakage in abdominal surgery |
| topic | C-reactive protein. Predictive value of tests. Anastomotic leak. Digestive system surgical procedures. |
| url | https://www.cirugiaycirujanos.com/frame_esp.php?id=758 |
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