Predicting Insignificant Prostate Cancer: Analysis of the Pathological Outcomes of Candidates for Active Surveillance according to the Pre-International Society of Urological Pathology (Pre-ISUP) 2014 Era Versus the Post-ISUP2014 Era
Purpose: To analyze the difference in the prediction accuracy with an active surveillance (AS) protocol between two eras (pre-International Society of Urological Pathology [pre-ISUP]-2014 vs. post-ISUP2014). Materials and Methods:Materials and Methods: We retrospectively analyzed 118 candidates for...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Society for Sexual Medicine and Andrology
2021-07-01
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| Series: | The World Journal of Men's Health |
| Subjects: |
| _version_ | 1823941087480250368 |
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| author | Mun Su Chung Nam Hoon Cho Jinu Kim Youngheun Jo Byung Il Yoon Seung Hwan Lee |
| author_facet | Mun Su Chung Nam Hoon Cho Jinu Kim Youngheun Jo Byung Il Yoon Seung Hwan Lee |
| author_sort | Mun Su Chung |
| collection | DOAJ |
| description | Purpose: To analyze the difference in the prediction accuracy with an active surveillance (AS) protocol between two eras (pre-International Society of Urological Pathology [pre-ISUP]-2014 vs. post-ISUP2014).
Materials and Methods:Materials and Methods: We retrospectively analyzed 118 candidates for AS who underwent radical prostatectomy between 2009 and 2017. We divided our patients into two groups (group 1 [n=57], operation date 2009–2015; group 2 [n=61], op-eration date 2016–2017). Pathologic slides in group 1 were reviewed to distinguish men with cribriform pattern (CP) because the determination of Gleason scores in old era had been based on pre-ISUP2014 classification. Postoperative outcomes in the two eras were analyzed twice: first, all men in group 1 vs. group 2; second, the remaining men after excluding those with CPs in group 1 vs. group 2.
Results:Results: The proportion of men with insignificant prostate cancer (iPCa) was significantly lower in group 1 than in group 2 (36.8% vs. 57.4%, p=0.040). After excluding 11 men with CPs from group 1, those remaining (46 men) were compared again with group 2. In this analysis, the proportion of men with iPCa was similar between the two groups (old vs. contempo-rary era: 41.3% vs. 57.4%, p=0.146). Nine of 11 men with CP had violated the criteria for iPCa in the earlier comparison. Conclusions:Conclusions: The accuracy of the AS protocol has been affected by the coexistence of CPs and pure Gleason 6 tumors in the pre-ISUP2014 era. We suggest to use only contemporary (post-ISUP2014) data to analyze the accuracy with AS protocols in future studies. |
| first_indexed | 2024-12-17T04:22:54Z |
| format | Article |
| id | doaj.art-70c56f5b07794a0da675c779e3c58193 |
| institution | Directory Open Access Journal |
| issn | 2287-4208 2287-4690 |
| language | English |
| last_indexed | 2024-12-17T04:22:54Z |
| publishDate | 2021-07-01 |
| publisher | Korean Society for Sexual Medicine and Andrology |
| record_format | Article |
| series | The World Journal of Men's Health |
| spelling | doaj.art-70c56f5b07794a0da675c779e3c581932022-12-21T22:03:47ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902021-07-0139355055810.5534/wjmh.200037Predicting Insignificant Prostate Cancer: Analysis of the Pathological Outcomes of Candidates for Active Surveillance according to the Pre-International Society of Urological Pathology (Pre-ISUP) 2014 Era Versus the Post-ISUP2014 EraMun Su Chung0https://orcid.org/0000-0002-9885-3559Nam Hoon Cho1https://orcid.org/0000-0002-0045-6441Jinu Kim2https://orcid.org/0000-0001-7468-364XYoungheun Jo3https://orcid.org/0000-0002-5604-9781Byung Il Yoon4https://orcid.org/0000-0003-0107-2818Seung Hwan Lee5https://orcid.org/0000-0001-7358-8544Catholic Kwandong University International St. Mary’s HospitalYonsei University College of MedicineYonsei University College of MedicineYonsei University College of MedicineCatholic Kwandong University International St. Mary’s HospitalYonsei University College of MedicinePurpose: To analyze the difference in the prediction accuracy with an active surveillance (AS) protocol between two eras (pre-International Society of Urological Pathology [pre-ISUP]-2014 vs. post-ISUP2014). Materials and Methods:Materials and Methods: We retrospectively analyzed 118 candidates for AS who underwent radical prostatectomy between 2009 and 2017. We divided our patients into two groups (group 1 [n=57], operation date 2009–2015; group 2 [n=61], op-eration date 2016–2017). Pathologic slides in group 1 were reviewed to distinguish men with cribriform pattern (CP) because the determination of Gleason scores in old era had been based on pre-ISUP2014 classification. Postoperative outcomes in the two eras were analyzed twice: first, all men in group 1 vs. group 2; second, the remaining men after excluding those with CPs in group 1 vs. group 2. Results:Results: The proportion of men with insignificant prostate cancer (iPCa) was significantly lower in group 1 than in group 2 (36.8% vs. 57.4%, p=0.040). After excluding 11 men with CPs from group 1, those remaining (46 men) were compared again with group 2. In this analysis, the proportion of men with iPCa was similar between the two groups (old vs. contempo-rary era: 41.3% vs. 57.4%, p=0.146). Nine of 11 men with CP had violated the criteria for iPCa in the earlier comparison. Conclusions:Conclusions: The accuracy of the AS protocol has been affected by the coexistence of CPs and pure Gleason 6 tumors in the pre-ISUP2014 era. We suggest to use only contemporary (post-ISUP2014) data to analyze the accuracy with AS protocols in future studies.neoplasm gradingprostatectomyprostatic neoplasmswatchful waiting |
| spellingShingle | Mun Su Chung Nam Hoon Cho Jinu Kim Youngheun Jo Byung Il Yoon Seung Hwan Lee Predicting Insignificant Prostate Cancer: Analysis of the Pathological Outcomes of Candidates for Active Surveillance according to the Pre-International Society of Urological Pathology (Pre-ISUP) 2014 Era Versus the Post-ISUP2014 Era The World Journal of Men's Health neoplasm grading prostatectomy prostatic neoplasms watchful waiting |
| title | Predicting Insignificant Prostate Cancer: Analysis of the Pathological Outcomes of Candidates for Active Surveillance according to the Pre-International Society of Urological Pathology (Pre-ISUP) 2014 Era Versus the Post-ISUP2014 Era |
| title_full | Predicting Insignificant Prostate Cancer: Analysis of the Pathological Outcomes of Candidates for Active Surveillance according to the Pre-International Society of Urological Pathology (Pre-ISUP) 2014 Era Versus the Post-ISUP2014 Era |
| title_fullStr | Predicting Insignificant Prostate Cancer: Analysis of the Pathological Outcomes of Candidates for Active Surveillance according to the Pre-International Society of Urological Pathology (Pre-ISUP) 2014 Era Versus the Post-ISUP2014 Era |
| title_full_unstemmed | Predicting Insignificant Prostate Cancer: Analysis of the Pathological Outcomes of Candidates for Active Surveillance according to the Pre-International Society of Urological Pathology (Pre-ISUP) 2014 Era Versus the Post-ISUP2014 Era |
| title_short | Predicting Insignificant Prostate Cancer: Analysis of the Pathological Outcomes of Candidates for Active Surveillance according to the Pre-International Society of Urological Pathology (Pre-ISUP) 2014 Era Versus the Post-ISUP2014 Era |
| title_sort | predicting insignificant prostate cancer analysis of the pathological outcomes of candidates for active surveillance according to the pre international society of urological pathology pre isup 2014 era versus the post isup2014 era |
| topic | neoplasm grading prostatectomy prostatic neoplasms watchful waiting |
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