Bioaccessibility and Bioavailability of Diet Polyphenols and Their Modulation of Gut Microbiota
It is generally accepted that diet-derived polyphenols are bioactive compounds with several potentially beneficial effects on human health. In general, polyphenols have several chemical structures, and the most representative are flavonoids, phenolic acids, and stilbenes. It should be noted that the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/4/3813 |
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| author | Tamara Lippolis Miriam Cofano Giusy Rita Caponio Valentina De Nunzio Maria Notarnicola |
| author_facet | Tamara Lippolis Miriam Cofano Giusy Rita Caponio Valentina De Nunzio Maria Notarnicola |
| author_sort | Tamara Lippolis |
| collection | DOAJ |
| description | It is generally accepted that diet-derived polyphenols are bioactive compounds with several potentially beneficial effects on human health. In general, polyphenols have several chemical structures, and the most representative are flavonoids, phenolic acids, and stilbenes. It should be noted that the beneficial effects of polyphenols are closely related to their bioavailability and bioaccessibility, as many of them are rapidly metabolized after administration. Polyphenols—with a protective effect on the gastrointestinal tract—promote the maintenance of the eubiosis of the intestinal microbiota with protective effects against gastric and colon cancers. Thus, the benefits obtained from dietary supplementation of polyphenols would seem to be mediated by the gut microbiota. Taken at certain concentrations, polyphenols have been shown to positively modulate the bacterial component, increasing <i>Lactiplantibacillus</i> spp. and <i>Bifidobacterium</i> spp. involved in the protection of the intestinal barrier and decreasing <i>Clostridium</i> and <i>Fusobacterium</i>, which are negatively associated with human well-being. Based on the diet–microbiota–health axis, this review aims to describe the latest knowledge on the action of dietary polyphenols on human health through the activity of the gut microbiota and discusses micro-encapsulation of polyphenols as a strategy to improve the microbiota. |
| first_indexed | 2024-03-11T08:41:55Z |
| format | Article |
| id | doaj.art-70c608cacda4443d90a4264107583669 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:41:55Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-70c608cacda4443d90a42641075836692023-11-16T21:05:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244381310.3390/ijms24043813Bioaccessibility and Bioavailability of Diet Polyphenols and Their Modulation of Gut MicrobiotaTamara Lippolis0Miriam Cofano1Giusy Rita Caponio2Valentina De Nunzio3Maria Notarnicola4National Institute of Gastroenterology—IRCCS “Saverio de Bellis”, 70013 Castellana Grotte, ItalyNational Institute of Gastroenterology—IRCCS “Saverio de Bellis”, 70013 Castellana Grotte, ItalyNational Institute of Gastroenterology—IRCCS “Saverio de Bellis”, 70013 Castellana Grotte, ItalyNational Institute of Gastroenterology—IRCCS “Saverio de Bellis”, 70013 Castellana Grotte, ItalyNational Institute of Gastroenterology—IRCCS “Saverio de Bellis”, 70013 Castellana Grotte, ItalyIt is generally accepted that diet-derived polyphenols are bioactive compounds with several potentially beneficial effects on human health. In general, polyphenols have several chemical structures, and the most representative are flavonoids, phenolic acids, and stilbenes. It should be noted that the beneficial effects of polyphenols are closely related to their bioavailability and bioaccessibility, as many of them are rapidly metabolized after administration. Polyphenols—with a protective effect on the gastrointestinal tract—promote the maintenance of the eubiosis of the intestinal microbiota with protective effects against gastric and colon cancers. Thus, the benefits obtained from dietary supplementation of polyphenols would seem to be mediated by the gut microbiota. Taken at certain concentrations, polyphenols have been shown to positively modulate the bacterial component, increasing <i>Lactiplantibacillus</i> spp. and <i>Bifidobacterium</i> spp. involved in the protection of the intestinal barrier and decreasing <i>Clostridium</i> and <i>Fusobacterium</i>, which are negatively associated with human well-being. Based on the diet–microbiota–health axis, this review aims to describe the latest knowledge on the action of dietary polyphenols on human health through the activity of the gut microbiota and discusses micro-encapsulation of polyphenols as a strategy to improve the microbiota.https://www.mdpi.com/1422-0067/24/4/3813diet-derived antioxidantsheathgut microbiotamicro-encapsulationpolyphenols |
| spellingShingle | Tamara Lippolis Miriam Cofano Giusy Rita Caponio Valentina De Nunzio Maria Notarnicola Bioaccessibility and Bioavailability of Diet Polyphenols and Their Modulation of Gut Microbiota International Journal of Molecular Sciences diet-derived antioxidants heath gut microbiota micro-encapsulation polyphenols |
| title | Bioaccessibility and Bioavailability of Diet Polyphenols and Their Modulation of Gut Microbiota |
| title_full | Bioaccessibility and Bioavailability of Diet Polyphenols and Their Modulation of Gut Microbiota |
| title_fullStr | Bioaccessibility and Bioavailability of Diet Polyphenols and Their Modulation of Gut Microbiota |
| title_full_unstemmed | Bioaccessibility and Bioavailability of Diet Polyphenols and Their Modulation of Gut Microbiota |
| title_short | Bioaccessibility and Bioavailability of Diet Polyphenols and Their Modulation of Gut Microbiota |
| title_sort | bioaccessibility and bioavailability of diet polyphenols and their modulation of gut microbiota |
| topic | diet-derived antioxidants heath gut microbiota micro-encapsulation polyphenols |
| url | https://www.mdpi.com/1422-0067/24/4/3813 |
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