A follow-up report on the published paper Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva
Abstract Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder associated with increased immune activity and severe, progressive heterotopic ossification. We previously described a cohort of 32 patients with FOP who were either exposed to SARS-CoV-2 or received a COVID-19 vaccine1 a...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Orphanet Journal of Rare Diseases |
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| Online Access: | https://doi.org/10.1186/s13023-023-02638-0 |
| _version_ | 1797863541310488576 |
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| author | Hayley Wallace Rhonda H. Lee Edward C. Hsiao |
| author_facet | Hayley Wallace Rhonda H. Lee Edward C. Hsiao |
| author_sort | Hayley Wallace |
| collection | DOAJ |
| description | Abstract Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder associated with increased immune activity and severe, progressive heterotopic ossification. We previously described a cohort of 32 patients with FOP who were either exposed to SARS-CoV-2 or received a COVID-19 vaccine1 and showed that these patients did not develop heterotopic ossification after COVID-19 vaccination. Here, we present additional clinical data from new subjects and additional long-term follow-up from the first cohort. We enrolled 15 new subjects between August 24th, 2021 and May 17th, 2022 and collected additional self-reported outcomes. The larger cohort with 47 individuals encompassing 49 events showed that patients with FOP exhibited no additional change in FOP disease activity or flare activity resulting from COVID-19 infection or after receipt of a SARS-CoV-2 vaccine. Thus, although any vaccination carries a risk of inducing heterotopic ossification in patients with FOP, our results show that patients with FOP who choose to receive a COVID-19 vaccination may be able to tolerate the procedure without a high risk of heterotopic ossification when following the published guidelines. |
| first_indexed | 2024-04-09T22:38:12Z |
| format | Article |
| id | doaj.art-70cb151f9262437bb90b40fd54b216f2 |
| institution | Directory Open Access Journal |
| issn | 1750-1172 |
| language | English |
| last_indexed | 2024-04-09T22:38:12Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Orphanet Journal of Rare Diseases |
| spelling | doaj.art-70cb151f9262437bb90b40fd54b216f22023-03-22T12:21:51ZengBMCOrphanet Journal of Rare Diseases1750-11722023-03-011811510.1186/s13023-023-02638-0A follow-up report on the published paper Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressivaHayley Wallace0Rhonda H. Lee1Edward C. Hsiao2Division of Endocrinology and Metabolism, The UCSF Metabolic Bone Clinic, University of California-San FranciscoDivision of Endocrinology and Metabolism, The UCSF Metabolic Bone Clinic, University of California-San FranciscoDivision of Endocrinology and Metabolism, The UCSF Metabolic Bone Clinic, University of California-San FranciscoAbstract Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder associated with increased immune activity and severe, progressive heterotopic ossification. We previously described a cohort of 32 patients with FOP who were either exposed to SARS-CoV-2 or received a COVID-19 vaccine1 and showed that these patients did not develop heterotopic ossification after COVID-19 vaccination. Here, we present additional clinical data from new subjects and additional long-term follow-up from the first cohort. We enrolled 15 new subjects between August 24th, 2021 and May 17th, 2022 and collected additional self-reported outcomes. The larger cohort with 47 individuals encompassing 49 events showed that patients with FOP exhibited no additional change in FOP disease activity or flare activity resulting from COVID-19 infection or after receipt of a SARS-CoV-2 vaccine. Thus, although any vaccination carries a risk of inducing heterotopic ossification in patients with FOP, our results show that patients with FOP who choose to receive a COVID-19 vaccination may be able to tolerate the procedure without a high risk of heterotopic ossification when following the published guidelines.https://doi.org/10.1186/s13023-023-02638-0Fibrodysplasia Ossificans Progressiva (FOP)COVID-19SARS-CoV-2VaccineHeterotopic Ossification (HO) |
| spellingShingle | Hayley Wallace Rhonda H. Lee Edward C. Hsiao A follow-up report on the published paper Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva Orphanet Journal of Rare Diseases Fibrodysplasia Ossificans Progressiva (FOP) COVID-19 SARS-CoV-2 Vaccine Heterotopic Ossification (HO) |
| title | A follow-up report on the published paper Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva |
| title_full | A follow-up report on the published paper Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva |
| title_fullStr | A follow-up report on the published paper Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva |
| title_full_unstemmed | A follow-up report on the published paper Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva |
| title_short | A follow-up report on the published paper Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva |
| title_sort | follow up report on the published paper social and clinical impact of covid 19 on patients with fibrodysplasia ossificans progressiva |
| topic | Fibrodysplasia Ossificans Progressiva (FOP) COVID-19 SARS-CoV-2 Vaccine Heterotopic Ossification (HO) |
| url | https://doi.org/10.1186/s13023-023-02638-0 |
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