mSphere of Influence: The discovery of a missing link in bacterial cell envelope biogenesis
ABSTRACTGregory Harrison is a bacteriologist researching essential pathways in bacteria as potential therapeutic targets. In this mSphere of Influence article, he reflects on a series of studies that employ complementary genetic approaches to define the crucial role of AsmA-family proteins in transp...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2024-02-01
|
Series: | mSphere |
Subjects: | |
Online Access: | https://journals.asm.org/doi/10.1128/msphere.00631-23 |
_version_ | 1797292552278245376 |
---|---|
author | Gregory A. Harrison |
author_facet | Gregory A. Harrison |
author_sort | Gregory A. Harrison |
collection | DOAJ |
description | ABSTRACTGregory Harrison is a bacteriologist researching essential pathways in bacteria as potential therapeutic targets. In this mSphere of Influence article, he reflects on a series of studies that employ complementary genetic approaches to define the crucial role of AsmA-family proteins in transporting phospholipids between the inner and outer membranes of Gram-negative bacteria. The authors of these three studies identify this family of lipid transporters through the means of bacterial genetics, answering a long-standing question in bacterial physiology, and serving as a reminder that a well-designed genetic strategy can go a long way in uncovering new biology. |
first_indexed | 2024-03-07T19:58:05Z |
format | Article |
id | doaj.art-70ce5dbdb98a44f2b40dc37bff8d2059 |
institution | Directory Open Access Journal |
issn | 2379-5042 |
language | English |
last_indexed | 2024-03-07T19:58:05Z |
publishDate | 2024-02-01 |
publisher | American Society for Microbiology |
record_format | Article |
series | mSphere |
spelling | doaj.art-70ce5dbdb98a44f2b40dc37bff8d20592024-02-28T14:07:38ZengAmerican Society for MicrobiologymSphere2379-50422024-02-019210.1128/msphere.00631-23mSphere of Influence: The discovery of a missing link in bacterial cell envelope biogenesisGregory A. Harrison0Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USAABSTRACTGregory Harrison is a bacteriologist researching essential pathways in bacteria as potential therapeutic targets. In this mSphere of Influence article, he reflects on a series of studies that employ complementary genetic approaches to define the crucial role of AsmA-family proteins in transporting phospholipids between the inner and outer membranes of Gram-negative bacteria. The authors of these three studies identify this family of lipid transporters through the means of bacterial genetics, answering a long-standing question in bacterial physiology, and serving as a reminder that a well-designed genetic strategy can go a long way in uncovering new biology.https://journals.asm.org/doi/10.1128/msphere.00631-23Gram-negative bacteriaouter membranephospholipidsAsmA-like proteins |
spellingShingle | Gregory A. Harrison mSphere of Influence: The discovery of a missing link in bacterial cell envelope biogenesis mSphere Gram-negative bacteria outer membrane phospholipids AsmA-like proteins |
title | mSphere of Influence: The discovery of a missing link in bacterial cell envelope biogenesis |
title_full | mSphere of Influence: The discovery of a missing link in bacterial cell envelope biogenesis |
title_fullStr | mSphere of Influence: The discovery of a missing link in bacterial cell envelope biogenesis |
title_full_unstemmed | mSphere of Influence: The discovery of a missing link in bacterial cell envelope biogenesis |
title_short | mSphere of Influence: The discovery of a missing link in bacterial cell envelope biogenesis |
title_sort | msphere of influence the discovery of a missing link in bacterial cell envelope biogenesis |
topic | Gram-negative bacteria outer membrane phospholipids AsmA-like proteins |
url | https://journals.asm.org/doi/10.1128/msphere.00631-23 |
work_keys_str_mv | AT gregoryaharrison msphereofinfluencethediscoveryofamissinglinkinbacterialcellenvelopebiogenesis |