mSphere of Influence: The discovery of a missing link in bacterial cell envelope biogenesis

ABSTRACTGregory Harrison is a bacteriologist researching essential pathways in bacteria as potential therapeutic targets. In this mSphere of Influence article, he reflects on a series of studies that employ complementary genetic approaches to define the crucial role of AsmA-family proteins in transp...

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Main Author: Gregory A. Harrison
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mSphere
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/msphere.00631-23
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author Gregory A. Harrison
author_facet Gregory A. Harrison
author_sort Gregory A. Harrison
collection DOAJ
description ABSTRACTGregory Harrison is a bacteriologist researching essential pathways in bacteria as potential therapeutic targets. In this mSphere of Influence article, he reflects on a series of studies that employ complementary genetic approaches to define the crucial role of AsmA-family proteins in transporting phospholipids between the inner and outer membranes of Gram-negative bacteria. The authors of these three studies identify this family of lipid transporters through the means of bacterial genetics, answering a long-standing question in bacterial physiology, and serving as a reminder that a well-designed genetic strategy can go a long way in uncovering new biology.
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spelling doaj.art-70ce5dbdb98a44f2b40dc37bff8d20592024-02-28T14:07:38ZengAmerican Society for MicrobiologymSphere2379-50422024-02-019210.1128/msphere.00631-23mSphere of Influence: The discovery of a missing link in bacterial cell envelope biogenesisGregory A. Harrison0Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USAABSTRACTGregory Harrison is a bacteriologist researching essential pathways in bacteria as potential therapeutic targets. In this mSphere of Influence article, he reflects on a series of studies that employ complementary genetic approaches to define the crucial role of AsmA-family proteins in transporting phospholipids between the inner and outer membranes of Gram-negative bacteria. The authors of these three studies identify this family of lipid transporters through the means of bacterial genetics, answering a long-standing question in bacterial physiology, and serving as a reminder that a well-designed genetic strategy can go a long way in uncovering new biology.https://journals.asm.org/doi/10.1128/msphere.00631-23Gram-negative bacteriaouter membranephospholipidsAsmA-like proteins
spellingShingle Gregory A. Harrison
mSphere of Influence: The discovery of a missing link in bacterial cell envelope biogenesis
mSphere
Gram-negative bacteria
outer membrane
phospholipids
AsmA-like proteins
title mSphere of Influence: The discovery of a missing link in bacterial cell envelope biogenesis
title_full mSphere of Influence: The discovery of a missing link in bacterial cell envelope biogenesis
title_fullStr mSphere of Influence: The discovery of a missing link in bacterial cell envelope biogenesis
title_full_unstemmed mSphere of Influence: The discovery of a missing link in bacterial cell envelope biogenesis
title_short mSphere of Influence: The discovery of a missing link in bacterial cell envelope biogenesis
title_sort msphere of influence the discovery of a missing link in bacterial cell envelope biogenesis
topic Gram-negative bacteria
outer membrane
phospholipids
AsmA-like proteins
url https://journals.asm.org/doi/10.1128/msphere.00631-23
work_keys_str_mv AT gregoryaharrison msphereofinfluencethediscoveryofamissinglinkinbacterialcellenvelopebiogenesis