The Possible Role of NLRP3 Inflammasome in Depression and Myocardial Infarction Comorbidity
It is well-established that cardiovascular disease and depression are highly comorbid. This study aimed to assess the possible role of the NOD-like receptor protein 3 (NLRP3) inflammasome pathway and the high-sensitivity C-reactive protein (<i>hs</i>CRP) in patients with incident myocard...
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MDPI AG
2023-08-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/9/1295 |
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| author | Erensu Baysak Cagan Yildirim Nurten Sayar Mustafa Kemal Sayar Angelos Halaris Feyza Aricioglu |
| author_facet | Erensu Baysak Cagan Yildirim Nurten Sayar Mustafa Kemal Sayar Angelos Halaris Feyza Aricioglu |
| author_sort | Erensu Baysak |
| collection | DOAJ |
| description | It is well-established that cardiovascular disease and depression are highly comorbid. This study aimed to assess the possible role of the NOD-like receptor protein 3 (NLRP3) inflammasome pathway and the high-sensitivity C-reactive protein (<i>hs</i>CRP) in patients with incident myocardial infarction in the presence or absence of depression. Sixty-eight consecutive patients with incident ST-elevation myocardial infarction and twenty healthy subjects were included. The patients were assessed using the Structured Clinical Interview for DSM-5 Disorders—Clinician Version during their 1–4-day-long hospitalization and were divided into two groups: with and without comorbid depression. Blood samples for the determination of NLRP3, interleukin-18 (IL-18), interleukin-1β (IL-1β), and <i>hs</i>CRP levels were analyzed using ELISA. NLRP3, IL-1β, IL-18, and <i>hs</i>CRP levels were significantly higher in myocardial infarction patients compared to the healthy group (<i>p</i> = 0.02, <i>p</i> < 0.001, <i>p</i> < 0.001, and <i>p</i> < 0.001, respectively). No significant difference was found between the myocardial groups with and without depression. However, in the logistic regression analysis, the NLRP3 variable in myocardial infarction patients was found to have a significant contribution to the likelihood of depression (<i>p</i> = 0.015, OR = 1.72, and CI = 1.11–2.66). The likelihood of depression is associated with increasing NLRP3 levels in myocardial infarction patients. However, this potential role should be further explored in a larger sample. |
| first_indexed | 2024-03-10T22:34:08Z |
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| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T22:34:08Z |
| publishDate | 2023-08-01 |
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| series | Journal of Personalized Medicine |
| spelling | doaj.art-70cee97e49f24a3bbfdd4e53f96f054f2023-11-19T11:30:15ZengMDPI AGJournal of Personalized Medicine2075-44262023-08-01139129510.3390/jpm13091295The Possible Role of NLRP3 Inflammasome in Depression and Myocardial Infarction ComorbidityErensu Baysak0Cagan Yildirim1Nurten Sayar2Mustafa Kemal Sayar3Angelos Halaris4Feyza Aricioglu5Department of Psychiatry, School of Medicine, Marmara University, Istanbul 34854, TurkeyDepartment of Cardiology, School of Medicine, Marmara University, Istanbul 34854, TurkeyDepartment of Cardiology, School of Medicine, Marmara University, Istanbul 34854, TurkeyDepartment of Psychiatry, School of Medicine, Marmara University, Istanbul 34854, TurkeyDepartment of Psychiatry and Behavioral Neurosciences, Stritch School of Medicine, Loyola University Medical Center, Loyola University Chicago, Maywood, IL 60153, USADepartment of Pharmacology, School of Dentistry and Institute of Health Sciences, Marmara University, Istanbul 34865, TurkeyIt is well-established that cardiovascular disease and depression are highly comorbid. This study aimed to assess the possible role of the NOD-like receptor protein 3 (NLRP3) inflammasome pathway and the high-sensitivity C-reactive protein (<i>hs</i>CRP) in patients with incident myocardial infarction in the presence or absence of depression. Sixty-eight consecutive patients with incident ST-elevation myocardial infarction and twenty healthy subjects were included. The patients were assessed using the Structured Clinical Interview for DSM-5 Disorders—Clinician Version during their 1–4-day-long hospitalization and were divided into two groups: with and without comorbid depression. Blood samples for the determination of NLRP3, interleukin-18 (IL-18), interleukin-1β (IL-1β), and <i>hs</i>CRP levels were analyzed using ELISA. NLRP3, IL-1β, IL-18, and <i>hs</i>CRP levels were significantly higher in myocardial infarction patients compared to the healthy group (<i>p</i> = 0.02, <i>p</i> < 0.001, <i>p</i> < 0.001, and <i>p</i> < 0.001, respectively). No significant difference was found between the myocardial groups with and without depression. However, in the logistic regression analysis, the NLRP3 variable in myocardial infarction patients was found to have a significant contribution to the likelihood of depression (<i>p</i> = 0.015, OR = 1.72, and CI = 1.11–2.66). The likelihood of depression is associated with increasing NLRP3 levels in myocardial infarction patients. However, this potential role should be further explored in a larger sample.https://www.mdpi.com/2075-4426/13/9/1295depression<i>hs</i>CRPmyocardial infarctionNLRP3NOD-like receptor protein 3 |
| spellingShingle | Erensu Baysak Cagan Yildirim Nurten Sayar Mustafa Kemal Sayar Angelos Halaris Feyza Aricioglu The Possible Role of NLRP3 Inflammasome in Depression and Myocardial Infarction Comorbidity Journal of Personalized Medicine depression <i>hs</i>CRP myocardial infarction NLRP3 NOD-like receptor protein 3 |
| title | The Possible Role of NLRP3 Inflammasome in Depression and Myocardial Infarction Comorbidity |
| title_full | The Possible Role of NLRP3 Inflammasome in Depression and Myocardial Infarction Comorbidity |
| title_fullStr | The Possible Role of NLRP3 Inflammasome in Depression and Myocardial Infarction Comorbidity |
| title_full_unstemmed | The Possible Role of NLRP3 Inflammasome in Depression and Myocardial Infarction Comorbidity |
| title_short | The Possible Role of NLRP3 Inflammasome in Depression and Myocardial Infarction Comorbidity |
| title_sort | possible role of nlrp3 inflammasome in depression and myocardial infarction comorbidity |
| topic | depression <i>hs</i>CRP myocardial infarction NLRP3 NOD-like receptor protein 3 |
| url | https://www.mdpi.com/2075-4426/13/9/1295 |
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