Impact of Mothers’ Schistosomiasis Status During Gestation on Children’s IgG Antibody Responses to Routine Vaccines 2 Years Later and Anti-Schistosome and Anti-Malarial Responses by Neonates in Western Kenya
The potential consequences of parasitic infections on a person’s immune responsiveness to unrelated antigens are often conjectured upon in relationship to allergic responses and autoimmune diseases. These considerations sometimes extend to whether parasitic infection of pregnant women can influence...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01402/full |
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| author | Bartholomew N. Ondigo Bartholomew N. Ondigo Erick M. O. Muok John K. Oguso Sammy M. Njenga Henry M. Kanyi Eric M. Ndombi Eric M. Ndombi Jeffrey W. Priest Nupur Kittur William Evan Secor Diana M. S. Karanja Daniel G. Colley Daniel G. Colley |
| author_facet | Bartholomew N. Ondigo Bartholomew N. Ondigo Erick M. O. Muok John K. Oguso Sammy M. Njenga Henry M. Kanyi Eric M. Ndombi Eric M. Ndombi Jeffrey W. Priest Nupur Kittur William Evan Secor Diana M. S. Karanja Daniel G. Colley Daniel G. Colley |
| author_sort | Bartholomew N. Ondigo |
| collection | DOAJ |
| description | The potential consequences of parasitic infections on a person’s immune responsiveness to unrelated antigens are often conjectured upon in relationship to allergic responses and autoimmune diseases. These considerations sometimes extend to whether parasitic infection of pregnant women can influence the outcomes of responses by their offspring to the immunizations administered during national Expanded Programs of Immunization. To provide additional data to these discussions, we have enrolled 99 close-to-term pregnant women in western Kenya and determined their Schistosoma mansoni and Plasmodium falciparum infection status. At 2 years of age, when the initial immunization schedule was complete, we determined their children’s IgG antibody levels to tetanus toxoid, diphtheria toxoid, and measles nucleoprotein (N-protein) antigens using a multiplex assay. We also monitored antibody responses during the children’s first 2 years of life to P. falciparum MSP119 (PfMSP119), S. mansoni Soluble Egg Antigen (SEA), Ascaris suum hemoglobin (AsHb), and Strongyloides stercoralis (SsNIE). Mothers’ infections with either P. falciparum or S. mansoni had no impact on the level of antibody responses of their offspring or the proportion of offspring that developed protective levels of antibodies to either tetanus or diphtheria antigens at 2 years of age. However, children born of S. mansoni-positive mothers and immunized for measles at 9 months of age had significantly lower levels of anti-measles N-protein antibodies when they were 2 years old (p = 0.007) and a lower proportion of these children (62.5 vs. 90.2%, OR = 0.18, 95% CI = 0.04–0.68, p = 0.011) were considered positive for measles N-protein antibodies. Decreased levels of measles antibodies may render these children more susceptible to measles infection than children whose mothers did not have schistosomiasis. None of the children demonstrated responses to AsHb or SsNIE during the study period. Anti-SEA and anti-PfMSP119 responses suggested that 6 and 70% of the children acquired schistosomes and falciparum malaria, respectively, during the first 2 years of life. |
| first_indexed | 2024-12-13T23:23:34Z |
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| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T23:23:34Z |
| publishDate | 2018-06-01 |
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| series | Frontiers in Immunology |
| spelling | doaj.art-70cf32aa8a4e44f3a5098d71f71b84a82022-12-21T23:27:38ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-06-01910.3389/fimmu.2018.01402387827Impact of Mothers’ Schistosomiasis Status During Gestation on Children’s IgG Antibody Responses to Routine Vaccines 2 Years Later and Anti-Schistosome and Anti-Malarial Responses by Neonates in Western KenyaBartholomew N. Ondigo0Bartholomew N. Ondigo1Erick M. O. Muok2John K. Oguso3Sammy M. Njenga4Henry M. Kanyi5Eric M. Ndombi6Eric M. Ndombi7Jeffrey W. Priest8Nupur Kittur9William Evan Secor10Diana M. S. Karanja11Daniel G. Colley12Daniel G. Colley13Centre for Global Health Research, Kenya Medical Research Institute (KEMRI), Kisumu, KenyaDepartment of Biochemistry and Molecular Biology, Egerton University, Nakuru, KenyaCentre for Global Health Research, Kenya Medical Research Institute (KEMRI), Kisumu, KenyaCentre for Global Health Research, Kenya Medical Research Institute (KEMRI), Kisumu, KenyaEastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research Institute (KEMRI), Nairobi, KenyaEastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research Institute (KEMRI), Nairobi, KenyaCentre for Global Health Research, Kenya Medical Research Institute (KEMRI), Kisumu, KenyaDepartment of Pathology, Kenyatta University, Nairobi, KenyaDivision of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United StatesCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, United StatesDivision of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United StatesCentre for Global Health Research, Kenya Medical Research Institute (KEMRI), Kisumu, KenyaCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, United StatesDepartment of Microbiology, University of Georgia, Athens, GA, United StatesThe potential consequences of parasitic infections on a person’s immune responsiveness to unrelated antigens are often conjectured upon in relationship to allergic responses and autoimmune diseases. These considerations sometimes extend to whether parasitic infection of pregnant women can influence the outcomes of responses by their offspring to the immunizations administered during national Expanded Programs of Immunization. To provide additional data to these discussions, we have enrolled 99 close-to-term pregnant women in western Kenya and determined their Schistosoma mansoni and Plasmodium falciparum infection status. At 2 years of age, when the initial immunization schedule was complete, we determined their children’s IgG antibody levels to tetanus toxoid, diphtheria toxoid, and measles nucleoprotein (N-protein) antigens using a multiplex assay. We also monitored antibody responses during the children’s first 2 years of life to P. falciparum MSP119 (PfMSP119), S. mansoni Soluble Egg Antigen (SEA), Ascaris suum hemoglobin (AsHb), and Strongyloides stercoralis (SsNIE). Mothers’ infections with either P. falciparum or S. mansoni had no impact on the level of antibody responses of their offspring or the proportion of offspring that developed protective levels of antibodies to either tetanus or diphtheria antigens at 2 years of age. However, children born of S. mansoni-positive mothers and immunized for measles at 9 months of age had significantly lower levels of anti-measles N-protein antibodies when they were 2 years old (p = 0.007) and a lower proportion of these children (62.5 vs. 90.2%, OR = 0.18, 95% CI = 0.04–0.68, p = 0.011) were considered positive for measles N-protein antibodies. Decreased levels of measles antibodies may render these children more susceptible to measles infection than children whose mothers did not have schistosomiasis. None of the children demonstrated responses to AsHb or SsNIE during the study period. Anti-SEA and anti-PfMSP119 responses suggested that 6 and 70% of the children acquired schistosomes and falciparum malaria, respectively, during the first 2 years of life.https://www.frontiersin.org/article/10.3389/fimmu.2018.01402/fullschistosomiasismalariaantibody responsestetanusdiphtheriameasles |
| spellingShingle | Bartholomew N. Ondigo Bartholomew N. Ondigo Erick M. O. Muok John K. Oguso Sammy M. Njenga Henry M. Kanyi Eric M. Ndombi Eric M. Ndombi Jeffrey W. Priest Nupur Kittur William Evan Secor Diana M. S. Karanja Daniel G. Colley Daniel G. Colley Impact of Mothers’ Schistosomiasis Status During Gestation on Children’s IgG Antibody Responses to Routine Vaccines 2 Years Later and Anti-Schistosome and Anti-Malarial Responses by Neonates in Western Kenya Frontiers in Immunology schistosomiasis malaria antibody responses tetanus diphtheria measles |
| title | Impact of Mothers’ Schistosomiasis Status During Gestation on Children’s IgG Antibody Responses to Routine Vaccines 2 Years Later and Anti-Schistosome and Anti-Malarial Responses by Neonates in Western Kenya |
| title_full | Impact of Mothers’ Schistosomiasis Status During Gestation on Children’s IgG Antibody Responses to Routine Vaccines 2 Years Later and Anti-Schistosome and Anti-Malarial Responses by Neonates in Western Kenya |
| title_fullStr | Impact of Mothers’ Schistosomiasis Status During Gestation on Children’s IgG Antibody Responses to Routine Vaccines 2 Years Later and Anti-Schistosome and Anti-Malarial Responses by Neonates in Western Kenya |
| title_full_unstemmed | Impact of Mothers’ Schistosomiasis Status During Gestation on Children’s IgG Antibody Responses to Routine Vaccines 2 Years Later and Anti-Schistosome and Anti-Malarial Responses by Neonates in Western Kenya |
| title_short | Impact of Mothers’ Schistosomiasis Status During Gestation on Children’s IgG Antibody Responses to Routine Vaccines 2 Years Later and Anti-Schistosome and Anti-Malarial Responses by Neonates in Western Kenya |
| title_sort | impact of mothers schistosomiasis status during gestation on children s igg antibody responses to routine vaccines 2 years later and anti schistosome and anti malarial responses by neonates in western kenya |
| topic | schistosomiasis malaria antibody responses tetanus diphtheria measles |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.01402/full |
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