Case–Control Study Investigating the Association Between Use of Selective Serotonin Reuptake Inhibitors and Pulmonary Tuberculosis in Taiwan
Background and Objective: The aim of the study was to investigate whether use of selective serotonin reuptake inhibitors (SSRIs) was associated with pulmonary tuberculosis. Methods: The case–control study was conducted to analyze the database between 2000 and 2013. Patients aged 20 to 84 years with...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-12-01
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| Series: | Dose-Response |
| Online Access: | https://doi.org/10.1177/1559325819897165 |
| _version_ | 1818108633791070208 |
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| author | Kao-Chi Cheng Kuan-Fu Liao Cheng-Li Lin Shih-Wei Lai |
| author_facet | Kao-Chi Cheng Kuan-Fu Liao Cheng-Li Lin Shih-Wei Lai |
| author_sort | Kao-Chi Cheng |
| collection | DOAJ |
| description | Background and Objective: The aim of the study was to investigate whether use of selective serotonin reuptake inhibitors (SSRIs) was associated with pulmonary tuberculosis. Methods: The case–control study was conducted to analyze the database between 2000 and 2013. Patients aged 20 to 84 years with newly diagnosed pulmonary tuberculosis were selected as the cases (n = 8593). Participants without pulmonary tuberculosis were selected as the controls (n = 43 472). Patients who never had a prescription for SSRIs were defined as never use. Those who ever had a prescription for SSRIs were defined as ever use. Results: The adjusted odds ratio (OR) of pulmonary tuberculosis was 1.03 for patients with ever use of SSRIs (95% confidence interval [CI]: 0.93-1.14), compared to never use. The adjusted OR of pulmonary tuberculosis was 1.00 for patients with increasing cumulative duration of SSRI use for every 1 month (95% CI: 0.99-1.00), compared to never use. The adjusted OR of pulmonary tuberculosis was 0.99 for patients with increasing cumulative dosage of SSRI use for every 1 mg (95% CI: 0.99-1.00), compared to never use. Conclusion: No significant association can be detected between SSRI use and pulmonary tuberculosis in Taiwan. No duration-dependent effect or dose-dependent effect of SSRIs use can be detected on the risk of pulmonary tuberculosis. |
| first_indexed | 2024-12-11T02:18:28Z |
| format | Article |
| id | doaj.art-70cf4273050740b88ebc6bd96991a44b |
| institution | Directory Open Access Journal |
| issn | 1559-3258 |
| language | English |
| last_indexed | 2024-12-11T02:18:28Z |
| publishDate | 2019-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Dose-Response |
| spelling | doaj.art-70cf4273050740b88ebc6bd96991a44b2022-12-22T01:24:07ZengSAGE PublishingDose-Response1559-32582019-12-011710.1177/1559325819897165Case–Control Study Investigating the Association Between Use of Selective Serotonin Reuptake Inhibitors and Pulmonary Tuberculosis in TaiwanKao-Chi Cheng0Kuan-Fu Liao1Cheng-Li Lin2Shih-Wei Lai3 Department of Food and Nutrition, Providence University, Taichung College of Medicine, Tzu Chi University, Hualien Management Office for Health Data, China Medical University Hospital, Taichung Department of Family Medicine, China Medical University Hospital, TaichungBackground and Objective: The aim of the study was to investigate whether use of selective serotonin reuptake inhibitors (SSRIs) was associated with pulmonary tuberculosis. Methods: The case–control study was conducted to analyze the database between 2000 and 2013. Patients aged 20 to 84 years with newly diagnosed pulmonary tuberculosis were selected as the cases (n = 8593). Participants without pulmonary tuberculosis were selected as the controls (n = 43 472). Patients who never had a prescription for SSRIs were defined as never use. Those who ever had a prescription for SSRIs were defined as ever use. Results: The adjusted odds ratio (OR) of pulmonary tuberculosis was 1.03 for patients with ever use of SSRIs (95% confidence interval [CI]: 0.93-1.14), compared to never use. The adjusted OR of pulmonary tuberculosis was 1.00 for patients with increasing cumulative duration of SSRI use for every 1 month (95% CI: 0.99-1.00), compared to never use. The adjusted OR of pulmonary tuberculosis was 0.99 for patients with increasing cumulative dosage of SSRI use for every 1 mg (95% CI: 0.99-1.00), compared to never use. Conclusion: No significant association can be detected between SSRI use and pulmonary tuberculosis in Taiwan. No duration-dependent effect or dose-dependent effect of SSRIs use can be detected on the risk of pulmonary tuberculosis.https://doi.org/10.1177/1559325819897165 |
| spellingShingle | Kao-Chi Cheng Kuan-Fu Liao Cheng-Li Lin Shih-Wei Lai Case–Control Study Investigating the Association Between Use of Selective Serotonin Reuptake Inhibitors and Pulmonary Tuberculosis in Taiwan Dose-Response |
| title | Case–Control Study Investigating the Association Between Use of Selective Serotonin Reuptake Inhibitors and Pulmonary Tuberculosis in Taiwan |
| title_full | Case–Control Study Investigating the Association Between Use of Selective Serotonin Reuptake Inhibitors and Pulmonary Tuberculosis in Taiwan |
| title_fullStr | Case–Control Study Investigating the Association Between Use of Selective Serotonin Reuptake Inhibitors and Pulmonary Tuberculosis in Taiwan |
| title_full_unstemmed | Case–Control Study Investigating the Association Between Use of Selective Serotonin Reuptake Inhibitors and Pulmonary Tuberculosis in Taiwan |
| title_short | Case–Control Study Investigating the Association Between Use of Selective Serotonin Reuptake Inhibitors and Pulmonary Tuberculosis in Taiwan |
| title_sort | case control study investigating the association between use of selective serotonin reuptake inhibitors and pulmonary tuberculosis in taiwan |
| url | https://doi.org/10.1177/1559325819897165 |
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