Cytotoxic Steroids From The Stembak of Chisocheton celebicus KOORD
In the course of our continuing search for anticancer compounds from Chisocheton species, three steroids, stigmast-5-en-3β-ol (1), stigmast-5-en-3β-ol-3-O-β-D-glucopyranoside (2) and stigmast-5,22-dien-3β-ol-3-O-β-D-glucopyranoside (3), were obtained from the stembark of Chisocheton celebicus. The s...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Indonesian |
| Published: |
Syarif Hidayatullah Jakarta State Islamic University
2019-11-01
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| Series: | Jurnal Kimia Valensi |
| Subjects: | |
| Online Access: | http://journal.uinjkt.ac.id/index.php/valensi/article/view/12132 |
| Summary: | In the course of our continuing search for anticancer compounds from Chisocheton species, three steroids, stigmast-5-en-3β-ol (1), stigmast-5-en-3β-ol-3-O-β-D-glucopyranoside (2) and stigmast-5,22-dien-3β-ol-3-O-β-D-glucopyranoside (3), were obtained from the stembark of Chisocheton celebicus. The structures of compound 1-3 were identified with spectroscopic data including IR, 1D-NMR, 2D-NMR and TOF-MS, as well as by comparing with those spectral data previously. Compounds 1-3, were evaluated for their cytotoxic effects against P-388 murine leukemia cells and displayed the cytotoxicity activity with IC50 values of 12.45 ± 0.050, 52.27 ± 0.031 and 62.52 ± 0.076 µg/mL, respectively. |
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| ISSN: | 2460-6065 2548-3013 |