Cytotoxic Steroids From The Stembak of Chisocheton celebicus KOORD
In the course of our continuing search for anticancer compounds from Chisocheton species, three steroids, stigmast-5-en-3β-ol (1), stigmast-5-en-3β-ol-3-O-β-D-glucopyranoside (2) and stigmast-5,22-dien-3β-ol-3-O-β-D-glucopyranoside (3), were obtained from the stembark of Chisocheton celebicus. The s...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Indonesian |
| Published: |
Syarif Hidayatullah Jakarta State Islamic University
2019-11-01
|
| Series: | Jurnal Kimia Valensi |
| Subjects: | |
| Online Access: | http://journal.uinjkt.ac.id/index.php/valensi/article/view/12132 |
| _version_ | 1828122821095587840 |
|---|---|
| author | Dewa Gede Katja Desi Harneti Tri Mayanti Nurlelasari Nurlelasari Rani Maharani Yoshihito Shiono Unang Supratman |
| author_facet | Dewa Gede Katja Desi Harneti Tri Mayanti Nurlelasari Nurlelasari Rani Maharani Yoshihito Shiono Unang Supratman |
| author_sort | Dewa Gede Katja |
| collection | DOAJ |
| description | In the course of our continuing search for anticancer compounds from Chisocheton species, three steroids, stigmast-5-en-3β-ol (1), stigmast-5-en-3β-ol-3-O-β-D-glucopyranoside (2) and stigmast-5,22-dien-3β-ol-3-O-β-D-glucopyranoside (3), were obtained from the stembark of Chisocheton celebicus. The structures of compound 1-3 were identified with spectroscopic data including IR, 1D-NMR, 2D-NMR and TOF-MS, as well as by comparing with those spectral data previously. Compounds 1-3, were evaluated for their cytotoxic effects against P-388 murine leukemia cells and displayed the cytotoxicity activity with IC50 values of 12.45 ± 0.050, 52.27 ± 0.031 and 62.52 ± 0.076 µg/mL, respectively. |
| first_indexed | 2024-04-11T14:41:43Z |
| format | Article |
| id | doaj.art-70d09b45d82c48cbaf90291ec0a0dbeb |
| institution | Directory Open Access Journal |
| issn | 2460-6065 2548-3013 |
| language | Indonesian |
| last_indexed | 2024-04-11T14:41:43Z |
| publishDate | 2019-11-01 |
| publisher | Syarif Hidayatullah Jakarta State Islamic University |
| record_format | Article |
| series | Jurnal Kimia Valensi |
| spelling | doaj.art-70d09b45d82c48cbaf90291ec0a0dbeb2022-12-22T04:17:50ZindSyarif Hidayatullah Jakarta State Islamic UniversityJurnal Kimia Valensi2460-60652548-30132019-11-015214314810.15408/jkv.v5i2.121325973Cytotoxic Steroids From The Stembak of Chisocheton celebicus KOORDDewa Gede Katja0Desi Harneti1Tri Mayanti2Nurlelasari Nurlelasari3Rani Maharani4Yoshihito Shiono5Unang Supratman6Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University Kampus Kleak, Manado, 95115, North Sulawesi, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University Jatinangor 45363, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University Jatinangor 45363, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University Jatinangor 45363, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University Jatinangor 45363, IndonesiaDepartment of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University Tsuruoka, Yamagata 997-8555, JapanDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University Jatinangor 45363, IndonesiaIn the course of our continuing search for anticancer compounds from Chisocheton species, three steroids, stigmast-5-en-3β-ol (1), stigmast-5-en-3β-ol-3-O-β-D-glucopyranoside (2) and stigmast-5,22-dien-3β-ol-3-O-β-D-glucopyranoside (3), were obtained from the stembark of Chisocheton celebicus. The structures of compound 1-3 were identified with spectroscopic data including IR, 1D-NMR, 2D-NMR and TOF-MS, as well as by comparing with those spectral data previously. Compounds 1-3, were evaluated for their cytotoxic effects against P-388 murine leukemia cells and displayed the cytotoxicity activity with IC50 values of 12.45 ± 0.050, 52.27 ± 0.031 and 62.52 ± 0.076 µg/mL, respectively.http://journal.uinjkt.ac.id/index.php/valensi/article/view/12132chisocheton celebicus koordcytotoxic activitymeliaceaep-388 murine leukemia cellssteroid |
| spellingShingle | Dewa Gede Katja Desi Harneti Tri Mayanti Nurlelasari Nurlelasari Rani Maharani Yoshihito Shiono Unang Supratman Cytotoxic Steroids From The Stembak of Chisocheton celebicus KOORD Jurnal Kimia Valensi chisocheton celebicus koord cytotoxic activity meliaceae p-388 murine leukemia cells steroid |
| title | Cytotoxic Steroids From The Stembak of Chisocheton celebicus KOORD |
| title_full | Cytotoxic Steroids From The Stembak of Chisocheton celebicus KOORD |
| title_fullStr | Cytotoxic Steroids From The Stembak of Chisocheton celebicus KOORD |
| title_full_unstemmed | Cytotoxic Steroids From The Stembak of Chisocheton celebicus KOORD |
| title_short | Cytotoxic Steroids From The Stembak of Chisocheton celebicus KOORD |
| title_sort | cytotoxic steroids from the stembak of chisocheton celebicus koord |
| topic | chisocheton celebicus koord cytotoxic activity meliaceae p-388 murine leukemia cells steroid |
| url | http://journal.uinjkt.ac.id/index.php/valensi/article/view/12132 |
| work_keys_str_mv | AT dewagedekatja cytotoxicsteroidsfromthestembakofchisochetoncelebicuskoord AT desiharneti cytotoxicsteroidsfromthestembakofchisochetoncelebicuskoord AT trimayanti cytotoxicsteroidsfromthestembakofchisochetoncelebicuskoord AT nurlelasarinurlelasari cytotoxicsteroidsfromthestembakofchisochetoncelebicuskoord AT ranimaharani cytotoxicsteroidsfromthestembakofchisochetoncelebicuskoord AT yoshihitoshiono cytotoxicsteroidsfromthestembakofchisochetoncelebicuskoord AT unangsupratman cytotoxicsteroidsfromthestembakofchisochetoncelebicuskoord |