The Biology and Therapeutic Implications of Tumor Dormancy and Reactivation
Advancements in the early detection of cancer coupled with improved surgery, radiotherapy, and adjuvant therapy led to substantial increase in patient survival. Nevertheless, cancer metastasis is the leading cause of death in several cancer patients. The majority of these deaths are associated with...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fonc.2018.00072/full |
| _version_ | 1811303502558789632 |
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| author | Amit S. Yadav Poonam R. Pandey Ramesh Butti N. N. V. Radharani Shamayita Roy Shaileshkumar R. Bhalara Mahadeo Gorain Gopal C. Kundu Dhiraj Kumar Dhiraj Kumar |
| author_facet | Amit S. Yadav Poonam R. Pandey Ramesh Butti N. N. V. Radharani Shamayita Roy Shaileshkumar R. Bhalara Mahadeo Gorain Gopal C. Kundu Dhiraj Kumar Dhiraj Kumar |
| author_sort | Amit S. Yadav |
| collection | DOAJ |
| description | Advancements in the early detection of cancer coupled with improved surgery, radiotherapy, and adjuvant therapy led to substantial increase in patient survival. Nevertheless, cancer metastasis is the leading cause of death in several cancer patients. The majority of these deaths are associated with metastatic relapse kinetics after a variable period of clinical remission. Most of the cancer recurrences are thought to be associated with the reactivation of dormant disseminated tumor cells (DTCs). In this review, we have summarized the cellular and molecular mechanisms related to DTCs and the role of microenvironmental niche. These mechanisms regulate the dormant state and help in the reactivation, which leads to metastatic outgrowth. Identification of novel therapeutic targets to eliminate these dormant tumor cells will be highly useful in controlling the metastatic relapse-related death with several cancers. |
| first_indexed | 2024-04-13T07:49:05Z |
| format | Article |
| id | doaj.art-70d135b1b7554dae8bfd7b5baa45666f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T07:49:05Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-70d135b1b7554dae8bfd7b5baa45666f2022-12-22T02:55:36ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-03-01810.3389/fonc.2018.00072329119The Biology and Therapeutic Implications of Tumor Dormancy and ReactivationAmit S. Yadav0Poonam R. Pandey1Ramesh Butti2N. N. V. Radharani3Shamayita Roy4Shaileshkumar R. Bhalara5Mahadeo Gorain6Gopal C. Kundu7Dhiraj Kumar8Dhiraj Kumar9Laboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre for Cell Science, Pune, IndiaLaboratory of Genetics, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD, United StatesLaboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre for Cell Science, Pune, IndiaLaboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre for Cell Science, Pune, IndiaLaboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre for Cell Science, Pune, IndiaLaboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre for Cell Science, Pune, IndiaLaboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre for Cell Science, Pune, IndiaLaboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre for Cell Science, Pune, IndiaLaboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre for Cell Science, Pune, IndiaDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesAdvancements in the early detection of cancer coupled with improved surgery, radiotherapy, and adjuvant therapy led to substantial increase in patient survival. Nevertheless, cancer metastasis is the leading cause of death in several cancer patients. The majority of these deaths are associated with metastatic relapse kinetics after a variable period of clinical remission. Most of the cancer recurrences are thought to be associated with the reactivation of dormant disseminated tumor cells (DTCs). In this review, we have summarized the cellular and molecular mechanisms related to DTCs and the role of microenvironmental niche. These mechanisms regulate the dormant state and help in the reactivation, which leads to metastatic outgrowth. Identification of novel therapeutic targets to eliminate these dormant tumor cells will be highly useful in controlling the metastatic relapse-related death with several cancers.http://journal.frontiersin.org/article/10.3389/fonc.2018.00072/fullcancer metastasisdormancyreactivationtumor microenvironmentepithelial to mesenchymal transition |
| spellingShingle | Amit S. Yadav Poonam R. Pandey Ramesh Butti N. N. V. Radharani Shamayita Roy Shaileshkumar R. Bhalara Mahadeo Gorain Gopal C. Kundu Dhiraj Kumar Dhiraj Kumar The Biology and Therapeutic Implications of Tumor Dormancy and Reactivation Frontiers in Oncology cancer metastasis dormancy reactivation tumor microenvironment epithelial to mesenchymal transition |
| title | The Biology and Therapeutic Implications of Tumor Dormancy and Reactivation |
| title_full | The Biology and Therapeutic Implications of Tumor Dormancy and Reactivation |
| title_fullStr | The Biology and Therapeutic Implications of Tumor Dormancy and Reactivation |
| title_full_unstemmed | The Biology and Therapeutic Implications of Tumor Dormancy and Reactivation |
| title_short | The Biology and Therapeutic Implications of Tumor Dormancy and Reactivation |
| title_sort | biology and therapeutic implications of tumor dormancy and reactivation |
| topic | cancer metastasis dormancy reactivation tumor microenvironment epithelial to mesenchymal transition |
| url | http://journal.frontiersin.org/article/10.3389/fonc.2018.00072/full |
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