MED1, a novel binding partner of BRCA1, regulates homologous recombination and R-loop processing
Abstract Homologous recombination (HR) is a major repair pathway of DNA double-strand breaks and is closely related to carcinogenesis. HR deficiency has been established as a therapeutic target. The aim of this study was to elucidate the functions of a novel HR factor, Mediator complex subunit 1 (ME...
Main Authors: | Harunori Honjoh, Michihiro Tanikawa, Osamu Wada-Hiraike, Katsutoshi Oda, Hirofumi Inaba, Asako Kukita, Yoshiko Kawata, Misako Kusakabe, Saki Tsuchimochi, Ayumi Taguchi, Yuichiro Miyamoto, Kenbun Sone, Tetsushi Tsuruga, Mayuyo Mori-Uchino, Yoko Matsumoto, Yutaka Osuga |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-10-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-022-21495-8 |
Similar Items
-
Characterization of a fluorescence imaging probe that exploits metabolic dependency of ovarian clear cell carcinoma
by: Saki Tsuchimochi, et al.
Published: (2023-11-01) -
Epigenetic Modifier SETD8 as a Therapeutic Target for High-Grade Serous Ovarian Cancer
by: Miku Wada, et al.
Published: (2020-12-01) -
Targeting Epigenetic Regulators for Endometrial Cancer Therapy: Its Molecular Biology and Potential Clinical Applications
by: Futaba Inoue, et al.
Published: (2021-02-01) -
Endometrial cancer with concomitant endometriosis is highly associated with ovarian endometrioid carcinoma: a retrospective cohort study
by: Aya Ishizaka, et al.
Published: (2022-08-01) -
Application of organoid culture from HPV18‐positive small cell carcinoma of the uterine cervix for precision medicine
by: Misako Kusakabe, et al.
Published: (2023-04-01)